Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | colchicine|64-86-8|Colchisol|Colchineos|Colcin|Colchicinum|Colchicin|Colchicina|Condylon|Colsaloid|Colcrys|7alphaH-Colchicine|Goutnil|Kolkicin|(S)-colchicine|(-)-colchicine|Colchysat|Mitigare|spindle poison|7-alpha-H-Colchicine|NSC 757|CCRIS 691|Colchcine |
|---|---|
| Specifications & Purity | Moligand™, analytical standard, ≥99%(HPLC) |
| Biochemical and Physiological Mechanisms | Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM). Studies indicate that Colchicine also causes apoptosis of cells by acting on tissue plasminogen activators ( |
| Storage Temp | Protected from light,Desiccated |
| Shipped In | Normal |
| Grade | analytical standard, Moligand™ |
| Product Description | Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis. |
Associated Targets
CYP1A2 Tchem Cytochrome P450 1A2 0 Activities
CYB561 Tbio Cytochrome b561 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
DRD2 Tclin D(2) dopamine receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
DRD4 Tchem D(4) dopamine receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
CYP3A4 Tclin Cytochrome P450 3A4 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ELANE Tclin Neutrophil elastase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
EGFR Tclin Epidermal growth factor receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TRPM7 Tchem Transient receptor potential cation channel subfamily M member 7 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HDAC6 Tclin Histone deacetylase 6 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HDAC1 Tclin Histone deacetylase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HDAC2 Tclin Histone deacetylase 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HRH1 Tclin Histamine H1 receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
PARP1 Tclin Poly [ADP-ribose] polymerase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
CA2 Tclin Carbonic anhydrase 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
DRD3 Tclin D(3) dopamine receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ADORA2A Tclin Adenosine receptor A2a 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ACHE Tclin Acetylcholinesterase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
AR Tclin Androgen receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
AKR1B1 Tclin Aldose reductase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ADORA1 Tclin Adenosine receptor A1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
ADORA3 Tchem Adenosine receptor A3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
BCHE Tclin Cholinesterase 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
EDNRA Tclin Endothelin-1 receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HDAC3 Tclin Histone deacetylase 3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
GLRA1 Tclin Glycine receptor subunit alpha-1 1 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
OPRK1 Tclin Kappa-type opioid receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
OPRM1 Tclin Mu-type opioid receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NOS2 Tchem Nitric oxide synthase, inducible 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TACR1 Tclin Substance-P receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NOS1 Tchem Nitric oxide synthase, brain 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Names and Identifiers
| IUPAC Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
|---|---|
| INCHI | InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
| InChi Key | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
| Canonical SMILES | CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| Isomeric SMILES | CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| WGK Germany | 3 |
| RTECS | GH0700000 |
| PubChem CID | 6167 |
| UN Number | 1544 |
| Packing Group | I |
| Molecular Weight | 399.44 |
| Beilstein | 2228813 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 J2318253 | Certificate of Analysis | Oct 13, 2023 | C106739 |
| J2318254 | Certificate of Analysis | Oct 13, 2023 | C106739 |
| K2103647 | Certificate of Analysis | Aug 22, 2023 | C106739 |
| G2120317 | Certificate of Analysis | Apr 18, 2023 | C106739 |
| B2317497 | Certificate of Analysis | Feb 06, 2023 | C106739 |
| B2317568 | Certificate of Analysis | Feb 06, 2023 | C106739 |
Chemical and Physical Properties
| Solubility | Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol., Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol. |
|---|---|
| Sensitivity | Light sensitive. |
| Specific Rotation[α] | -238° (C=1,EtOH) |
| Melt Point(°C) | 150-160°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS06, GHS08 |
|---|---|
| Signal | Danger |
| Hazard Statements | H300:Fatal if swallowed H340:May cause genetic defects |
| Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. |
| WGK Germany | 3 |
| RTECS | GH0700000 |
| Class | 6.1 |
| Merck Index | 2471 |