Colchicine - for plant cell culture,≥98%(HPLC), high purity , CAS No.64-86-8, Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I
Colchicine - for plant cell culture,≥98%(HPLC), high purity , CAS No.64-86-8, Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I
Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM). Studies indicate that Colchicine also causes apoptosis of cells by acting on tissue plasminogen activators (
Storage Temp
Protected from light,Argon charged,Desiccated
Shipped In
Normal
Grade
for plant cell culture, Moligand™
Action Type
AGONIST, ANTAGONIST, INHIBITOR
Mechanism of action
Inhibitor of bromodomain containing 4;Antagonist of glycine receptor α1 subunit;Antagonist of glycine receptor α2 subunit;Agonist of TAS2R46;Agonist of TAS2R4;Inhibitor of tubulin beta class I
Product Description
Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis. A mitosis inhibitor useful in cell division studies
Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol., Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol.
1.Reyes AZ, Hu KA, Teperman J, Wampler Muskardin TL, Tardif JC, Shah B, Pillinger MH. (2020) Anti-inflammatory therapy for COVID-19 infection: the case for colchicine.. Ann Rheum Dis, 129 (3):(589-97). [PMID:33293273]
2.Vrachatis DA, Giannopoulos GV, Giotaki SG, Raisakis K, Kossyvakis C, Iliodromitis KE, Reimers B, Tousoulis D, Cleman M, Stefanadis C et al.. (2021) Impact of colchicine on mortality in patients with COVID-19: A meta-analysis.. Hellenic J Cardiol, 129 (3):(589-97). [PMID:33421583]
3.Martínez GJ, Celermajer DS, Patel S. (2018) The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation.. Atherosclerosis, 269 (3):(262-271). [PMID:29352570]
4.Schlesinger N, Firestein BL, Brunetti L. (2020) Colchicine in COVID-19: an Old Drug, New Use.. Curr Pharmacol Rep, 129 (3):(1-9). [PMID:32837853]
5.Papadopoulos C, Patoulias D, Teperikidis E, Mouselimis D, Tsarouchas A, Toumpourleka M, Boulmpou A, Bakogiannis C, Doumas M, Vassilikos VP. (2020) Colchicine as a Potential Therapeutic Agent Against Cardiovascular Complications of COVID-19: an Exploratory Review.. SN Compr Clin Med, 129 (3):(1-11). [PMID:32838182]
6.Sandhu T, Tieng A, Chilimuri S, Franchin G. (2020) A Case Control Study to Evaluate the Impact of Colchicine on Patients Admitted to the Hospital with Moderate to Severe COVID-19 Infection.. Can J Infect Dis Med Microbiol, 2020 (3):(8865954). [PMID:33133323]
7.Healy LD, McCarty OJT. (2019) Contact system sends defensins to the rescue.. Blood, 133 (5):(385-386). [PMID:30705047]
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G2208337
