Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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C294476-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $447.90 |
Synonyms | colchicine | 64-86-8 | Colchisol | Colchineos | Colcin | Colchicinum | Colchicin | Colchicina | Condylon | Colsaloid | Colcrys | 7alphaH-Colchicine | Goutnil | Kolkicin | (S)-colchicine | (-)-colchicine | Colchysat | Mitigare | spindle poison | 7-alpha-H-Colchicine | NSC 757 | CCRIS 691 | Colchcine |
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Specifications & Purity | Moligand™, 1 mg/mL in acetonitrile, certified reference material, ampule of 1 mL 1ml |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Tubulin inhibitor |
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IUPAC Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
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INCHI | InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
InChi Key | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
Canonical SMILES | CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
Isomeric SMILES | CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
WGK Germany | 3 |
RTECS | GH0700000 |
PubChem CID | 6167 |
UN Number | 1544 |
Packing Group | I |
Molecular Weight | 399.44 |
Beilstein | 2228813 |
Enter Lot Number to search for COA:
Specific Rotation[α] | -238° (C=1,EtOH) |
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Melt Point(°C) | 150-160°C |
Pictogram(s) | GHS06, GHS08 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H340:May cause genetic defects |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | GH0700000 |
Class | 6.1 |
Merck Index | 2471 |
1. Yunbo Yan, Linqian Yu, Binyang Chen, Chang’an Cao, Hairong Zhao, Qiang Wang, De Xie, Yuemei Xi, Chenggui Zhang, Jidong Cheng. (2023) Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis. Journal of Inflammation Research, [PMID:38116368] |
2. Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia. (2024) Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer. JOURNAL OF CONTROLLED RELEASE, 365 (1): (112). [PMID:37981050] |
3. Fang Ruiyue, Zhao Ying, Lin Shiyuan, Wei Yue, Chen Hui. (2023) Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoformulation. Drug Delivery and Translational Research, (1-16). [PMID:37787882] |
4. Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang. (2023) Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting. JOURNAL OF LIPOSOME RESEARCH, [PMID:36974836] |
5. Liping Zhang, Yuan Xu, Wenjuan Cao, Shibao Xie, Lu Wen, Gang Chen. (2023) Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine. International Journal of Nanomedicine, [PMID:29403277] |
6. Zhang Lin, Dong Yi, Lu Yunhao, Mo Rui, He Qiang. (2023) Photolysis and cytotoxicity of the potentially toxic composition of daylily flower: colchicine. Journal of Food Measurement and Characterization, 17 (3): (2978-2987). [PMID:] |
7. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan. (2022) A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy. Frontiers in Pharmacology, 13 [PMID:36438812] |
8. Yuhan Yang, Yangyi Chen, Dianpeng Li, Shiyuan Lin, Hui Chen, Wei Wu, Wei Zhang. (2023) Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter. CARBOHYDRATE POLYMERS, 300 (120233). [PMID:36372473] |
9. Baogui Xu, Jiawen Zheng, Xiaoxiao Tian, Falei Yuan, zhongliang Liu, Yafeng Zhou, Zuisu Yang, Xianjun Ding. (2022) Protective mechanism of traditional Chinese medicine guizhi fuling pills against carbon tetrachloride-induced kidney damage is through inhibiting oxidative stress, inflammation and regulating the intestinal flora. PHYTOMEDICINE, 101 (154129). [PMID:35490491] |
10. Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui. (2022) Dual crosslinking of folic acid-modified pectin nanoparticles for enhanced oral insulin delivery. Biomaterials Advances, 135 (212746). [PMID:35929218] |
11. Jihui Zhang, Hongwei Lei, Xiu Li. (2022) The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis. Bioengineered, 13 (1): (345-356). [PMID:34965184] |
12. Yang Zhong, Jiayu Gu, Yaoquan Su, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng. (2022) Real-time screening of hepatotoxins in natural medicine by peroxynitrite responsive lanthanide-based NIR-II luminescent probes. CHEMICAL ENGINEERING JOURNAL, 433 (133263). [PMID:] |
13. Qing Wang,Jie Chen,Kun Huang,Xin Zhang,Li Xu,Zhi-guo Shi. (2014-12-07) Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia-zirconia stationary phase.. Analytica chimica acta, 854 (191-201). [PMID:25479884] |
14. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi. (2015-09-01) A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications.. Analytica chimica acta, 888 (182-190). [PMID:26320974] |
1. Yunbo Yan, Linqian Yu, Binyang Chen, Chang’an Cao, Hairong Zhao, Qiang Wang, De Xie, Yuemei Xi, Chenggui Zhang, Jidong Cheng. (2023) Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis. Journal of Inflammation Research, [PMID:38116368] |
2. Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia. (2024) Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer. JOURNAL OF CONTROLLED RELEASE, 365 (1): (112). [PMID:37981050] |
3. Fang Ruiyue, Zhao Ying, Lin Shiyuan, Wei Yue, Chen Hui. (2023) Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoformulation. Drug Delivery and Translational Research, (1-16). [PMID:37787882] |
4. Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang. (2023) Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting. JOURNAL OF LIPOSOME RESEARCH, [PMID:36974836] |
5. Liping Zhang, Yuan Xu, Wenjuan Cao, Shibao Xie, Lu Wen, Gang Chen. (2023) Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine. International Journal of Nanomedicine, [PMID:29403277] |
6. Zhang Lin, Dong Yi, Lu Yunhao, Mo Rui, He Qiang. (2023) Photolysis and cytotoxicity of the potentially toxic composition of daylily flower: colchicine. Journal of Food Measurement and Characterization, 17 (3): (2978-2987). [PMID:] |
7. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan. (2022) A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy. Frontiers in Pharmacology, 13 [PMID:36438812] |
8. Yuhan Yang, Yangyi Chen, Dianpeng Li, Shiyuan Lin, Hui Chen, Wei Wu, Wei Zhang. (2023) Linolenic acid conjugated chitosan micelles for improving the oral absorption of doxorubicin via fatty acid transporter. CARBOHYDRATE POLYMERS, 300 (120233). [PMID:36372473] |
9. Baogui Xu, Jiawen Zheng, Xiaoxiao Tian, Falei Yuan, zhongliang Liu, Yafeng Zhou, Zuisu Yang, Xianjun Ding. (2022) Protective mechanism of traditional Chinese medicine guizhi fuling pills against carbon tetrachloride-induced kidney damage is through inhibiting oxidative stress, inflammation and regulating the intestinal flora. PHYTOMEDICINE, 101 (154129). [PMID:35490491] |
10. Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui. (2022) Dual crosslinking of folic acid-modified pectin nanoparticles for enhanced oral insulin delivery. Biomaterials Advances, 135 (212746). [PMID:35929218] |
11. Jihui Zhang, Hongwei Lei, Xiu Li. (2022) The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis. Bioengineered, 13 (1): (345-356). [PMID:34965184] |
12. Yang Zhong, Jiayu Gu, Yaoquan Su, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng. (2022) Real-time screening of hepatotoxins in natural medicine by peroxynitrite responsive lanthanide-based NIR-II luminescent probes. CHEMICAL ENGINEERING JOURNAL, 433 (133263). [PMID:] |
13. Qing Wang,Jie Chen,Kun Huang,Xin Zhang,Li Xu,Zhi-guo Shi. (2014-12-07) Preparation, characterization and application of N-methylene phosphonic acid chitosan grafted magnesia-zirconia stationary phase.. Analytica chimica acta, 854 (191-201). [PMID:25479884] |
14. Qing Wang,Mao Ye,Li Xu,Zhi-guo Shi. (2015-09-01) A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications.. Analytica chimica acta, 888 (182-190). [PMID:26320974] |