Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of tubulin beta 3 class III
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Griggs J, Metcalfe JC, Hesketh R. (2001) Targeting tumour vasculature: the development of combretastatin A4.. Lancet Oncol, 2 (2):(82-7). [PMID:11905799]
2.Lin CM, Singh SB, Chu PS, Dempcy RO, Schmidt JM, Pettit GR, Hamel E. (1988) Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.. Mol Pharmacol, 34 (2):(200-8). [PMID:3412321]
3.Quayle LA et al.. (2017) Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action.. Oncotarget, 8 (51):(88670-88688). [PMID:29179466]
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L1910060