Basic Description

Synonyms	Combretastatin A4 \| 117048-59-6 \| Combretastatin A-4 \| Combrestatin A4 \| (Z)-2-METHOXY-5-(3,4,5-TRIMETHOXYSTYRYL)PHENOL \| Crc 87-09 \| Combretastatin 4 \| Combretastatin-A4 \| CA-4 \| 2'-deoxycombretastatin A1 \| NSC 817373 \| NSC-613729 \| 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)et
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets(Human)

TUBB1 Tclin Tubulin beta-1 chain (1 Activities)

Discover Target: TUBB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB1 Tchem Multidrug resistance protein 1 (2 Activities)

Discover Target: ABCB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TUBB3 Tclin Tubulin beta-3 chain (4 Activities)

Discover Target: TUBB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBB3 Tclin Tubulin beta-3 chain (22 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBB1 Tclin Tubulin beta-1 chain (182 Activities)

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1A9 (618 Activities)

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A-375 (9258 Activities)

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A498 (42825 Activities)

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ACHN (49357 Activities)

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AGS (1999 Activities)

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BeWo (124 Activities)

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BT-474 (2113 Activities)

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BXPC-3 (2997 Activities)

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CA46 (271 Activities)

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CAKI-1 (44928 Activities)

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Calu-1 (518 Activities)

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Calu-6 (398 Activities)

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CAPAN-1 (772 Activities)

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CCRF-CEM (65223 Activities)

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CEM-DNR (114 Activities)

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CEM-SS (2428 Activities)

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COLO 205 (50209 Activities)

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Daoy (570 Activities)

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DLD-1 (17511 Activities)

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DMS-79 (150 Activities)

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DMS-273 (14108 Activities)

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DU-145 (51482 Activities)

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ECV-304 (406 Activities)

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HCT-8 (3484 Activities)

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HL-60 (67320 Activities)

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HT-1080 (3966 Activities)

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HT-29 (80576 Activities)

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Huh-7 (12904 Activities)

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HuTu80 (255 Activities)

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IMR-32 (1082 Activities)

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K562 (73714 Activities)

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KB 3-1 (1143 Activities)

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KM12 (47707 Activities)

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LoVo (4724 Activities)

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M14 (47487 Activities)

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MCF-10A (2462 Activities)

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MCF7 (126967 Activities)

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MCF7-DOX (137 Activities)

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MDA-MB-468 (9477 Activities)

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MES-SA (905 Activities)

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MES-SA/Dx5 (643 Activities)

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MKN-45 (2102 Activities)

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Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)

Discover Target: pol

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBB2B Tubulin beta chain (424 Activities)

Discover Target: TUBB2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBA1A Tubulin alpha chain (497 Activities)

Discover Target: TUBA1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HD1 Histone deacetylase (38 Activities)

Discover Target: HD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

beta-tubulin Beta tubulin (90 Activities)

Discover Target: beta-tubulin

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Micrococcus luteus (7463 Activities)

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Neisseria gonorrhoeae (1461 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Gallus gallus (1187 Activities)

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Bos taurus (956 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Human immunodeficiency virus 2 (5592 Activities)

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A10 (235 Activities)

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B16 (5829 Activities)

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CCRF S-180 (1031 Activities)

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EMT6 (738 Activities)

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FM3A (1296 Activities)

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L1210 (27553 Activities)

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P388 (20296 Activities)

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Vero (26788 Activities)

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MC-38 (857 Activities)

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Colon 26 (524 Activities)

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NIH3T3 (5395 Activities)

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HT-22 (3261 Activities)

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L929 (3802 Activities)

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H22 (575 Activities)

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BMEC (52 Activities)

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B16-F10 (4610 Activities)

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Dengue virus type 2 NS3 protein (2214 Activities)

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CT26 (928 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TOP1 DNA topoisomerase 1 (4 Activities)

Discover Target: TOP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc22a6 Solute carrier family 22 member 6 (141 Activities)

Discover Target: Slc22a6

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dengue virus type 2 (2400 Activities)

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Paracentrotus lividus (1138 Activities)

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Plasma (328 Activities)

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Brontispa longissima (195 Activities)

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TUBB2B Tubulin (2175 Activities)

Discover Target: TUBB2B

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8238086 Cytochrome P450 (0 Activities)

Discover Target: 8238086

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Liver microsome (341 Activities)

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Chorioallantoic membrane (375 Activities)

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B16-BL6 (75 Activities)

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Zika virus (1028 Activities)

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SARS-CoV-2 (38078 Activities)

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E0771 (9 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
INCHI	InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InChi Key	HVXBOLULGPECHP-WAYWQWQTSA-N
Canonical SMILES	COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
Isomeric SMILES	COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)O
WGK Germany	2
PubChem CID	5351344
Molecular Weight	316.35
Reaxy-Rn	4786976

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Light sensitive
Melt Point(°C)	83 °C

Safety and Hazards(GHS)

Signal	Danger
Hazard Statements	H318:Causes serious eye damage
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P311:Call a POISON CENTER or doctor/...
WGK Germany	2
Reaxy-Rn	4786976
Merck Index	2494

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yibin Liu, Fuan Deng, Rongrong Zheng, Xiayun Chen, Linping Zhao, Baixue Yu, Ali Chen, Xueyan Jiang, Hong Cheng, Shiying Li. (2022) Self-delivery nanomedicine for vascular disruption-supplemented chemo-photodynamic tumor therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 612 (562). [PMID:35026565] [10.1016/j.jcis.2021.12.128]

References

1. Yibin Liu, Fuan Deng, Rongrong Zheng, Xiayun Chen, Linping Zhao, Baixue Yu, Ali Chen, Xueyan Jiang, Hong Cheng, Shiying Li. (2022) Self-delivery nanomedicine for vascular disruption-supplemented chemo-photodynamic tumor therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 612 (562). [PMID:35026565] [10.1016/j.jcis.2021.12.128]

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Combretastatin A4 - 10mM in DMSO, high purity , CAS No.117048-59-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator