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Conoidin A - 10mM in DMSO, high purity , CAS No.18080-67-6(DMSO)
Basic Description Synonyms DTXSID30333530 | NCGC00247880-01 | 2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide | 2,3-Bis(bromomethyl)quinoxaline 1,4-dioxide | HY-116090 | Conoidin A | 2,3-BIS(BROMOMETHYL)-1-OXOQUINOXALIN-1-IUM-4(1H)-OLATE | AKOS002529306 | AS-80564 | EC-000.1469 | 2,3- Specifications & Purity 10mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Biological activity:
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 µM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII)[1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2,3-bis(bromomethyl)-4-oxidoquinoxalin-1-ium 1-oxide INCHI InChI=1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2 InChi Key DQKNFTLRMZOAMG-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C(=C1)N(C(=C([N+]2=O)CBr)CBr)[O-] Isomeric SMILES C1=CC=C2C(=C1)N(C(=C([N+]2=O)CBr)CBr)[O-] PubChem CID 511509 Molecular Weight 347.99
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