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Cordycepin - 98%, high purity , CAS No.73-03-0

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Moligand™

≥98%

CAS#: 73-03-0
Formula: C₁₀H₁₃N₅O₃
Molecular Weight: 251.24
Beilstein Registry Number: 35194
EC Number: 200-791-4
MDL number: MFCD00037998
PubChem CID: 6303
PubChem SID: 488180045

Item Number

C110081

Grouped product items
SKU	Size	Availability	Price
C110081-25mg	25mg	In stock	$118.90
C110081-100mg	100mg	In stock	$330.90
C110081-500mg	500mg	In stock	$1,489.90
C110081-1g	1g	In stock	$2,681.90

Nucleoside antagonist. Inhibits NF-κB signaling

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Basic Description

Synonyms	Cordycepin, from Cordyceps militaris \| CORDYCEPIN [MI] \| 9-(3-Deoxy-b-D-erythro-pentofuranosyl)-9H-purin-6-amine \| Cordycepin, >=98.0% (HPLC) \| UNII-GZ8VF4M2J8 \| AC-22613 \| MFCD00037998 \| NSC-63984 \| Q2256677 \| Z3041517973 \| AKOS015854875 \| (2R,3R,5S)-2-(
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Nucleoside antagonist, able to interfere with RNA synthesis. Inhibits NF-κB signaling. Anti-inflammatory and antitumor effects in vitro and in vivo .
Source	from Cordyceps militaris
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription. An anticancer, antifungal nucleoside analog.

Associated Targets(Human)

ADA Tclin Adenosine deaminase (129 Activities)

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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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BXPC-3 (2997 Activities)

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CCRF-CEM (65223 Activities)

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HL-60 (67320 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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MT4 (17854 Activities)

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RPMI-8226 (44974 Activities)

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THP-1 (11052 Activities)

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MIA PaCa-2 (5949 Activities)

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HepG2 (196354 Activities)

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Jurkat (10389 Activities)

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KG-1 (867 Activities)

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SW-620 (52400 Activities)

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MV4-11 (7307 Activities)

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TLR4 Tchem Toll-like receptor 4 (970 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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RL (305 Activities)

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NCI-H929 (451 Activities)

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HEL 92.1.7 (74 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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NS5B Hepatitis C virus NS5B RNA-dependent RNA polymerase (3026 Activities)

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Trypanosoma brucei (78846 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Plasmodium falciparum (966862 Activities)

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Leishmania donovani (89745 Activities)

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Trypanosoma cruzi (99888 Activities)

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Trichomonas vaginalis (2376 Activities)

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Human alphaherpesvirus 2 (4932 Activities)

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Human respirovirus 3 (1674 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Vaccinia virus (4609 Activities)

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Human alphaherpesvirus 1 (11089 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Poliovirus 1 (1274 Activities)

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Semliki Forest virus (705 Activities)

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Sindbis virus (1599 Activities)

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Hepatitis C virus (23859 Activities)

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Vesicular stomatitis virus (4460 Activities)

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Coxsackievirus B4 (2249 Activities)

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Vero (26788 Activities)

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NIH3T3 (5395 Activities)

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L929 (3802 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Rela Transcription factor p65 (175 Activities)

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Mammalian orthoreovirus 1 (1523 Activities)

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CYP51 Sterol 14-alpha demethylase (857 Activities)

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ATP-dependent molecular chaperone HSP82 (2186 Activities)

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TIM23 Mitochondrial import inner membrane translocase subunit TIM23 (781 Activities)

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488180045
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488180045
IUPAC Name	(2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
INCHI	InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1
InChi Key	OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Canonical SMILES	C1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO
Isomeric SMILES	C1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C(N=CN=C32)N)CO
WGK Germany	3
RTECS	AU7358610
PubChem CID	6303
UN Number	2811
Molecular Weight	251.24
Beilstein	35194
Reaxy-Rn	35194

Database links

PubChem CID	6303
Wikipedia	Cordycepin
CAS Registry No.	73-03-0
ChEMBL Ligand	CHEMBL305686
RCSB PDB Ligand	3AD
PubChem SID	488180045

Certificates

Certificate of Analysis(COA)

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18 results found

Lot Number	Certificate Type	Date	Item
G2315527	Certificate of Analysis	Jul 21, 2023	C110081
G2315524	Certificate of Analysis	Jul 21, 2023	C110081
G2315441	Certificate of Analysis	Jul 21, 2023	C110081
G2315439	Certificate of Analysis	Jul 21, 2023	C110081
F2415067	Certificate of Analysis	Jul 06, 2023	C110081
K2422321	Certificate of Analysis	Jul 06, 2023	C110081
I2321107	Certificate of Analysis	Jul 06, 2023	C110081
I2321092	Certificate of Analysis	Jul 06, 2023	C110081
I2321091	Certificate of Analysis	Jul 06, 2023	C110081
B2328543	Certificate of Analysis	Feb 04, 2023	C110081
B2328538	Certificate of Analysis	Feb 04, 2023	C110081
B2328537	Certificate of Analysis	Feb 04, 2023	C110081
B2328530	Certificate of Analysis	Feb 04, 2023	C110081
B2328526	Certificate of Analysis	Feb 04, 2023	C110081
B2225352	Certificate of Analysis	Dec 15, 2021	C110081
B2225372	Certificate of Analysis	Dec 15, 2021	C110081
B2225371	Certificate of Analysis	Dec 15, 2021	C110081
B2225370	Certificate of Analysis	Dec 15, 2021	C110081

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Chemical and Physical Properties

Solubility	Soluble in DMSO (100 mM), methanol, and water
Sensitivity	heat sensitive;Moisture sensitive
Specific Rotation[α]	-46° (C=1,H2O)
Melt Point(°C)	224-228°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	AU7358610
Reaxy-Rn	35194
Class	6.1
Merck Index	2529

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao. (2023) Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway. BIOMEDICINE & PHARMACOTHERAPY, 163 (114776). [PMID:37100012] [10.1016/j.biopha.2023.114776]
2. Xinyue Li, Yuanyuan Fan, Zhengbao Zha, Deyan Gong, Jiajia Yu, Qianhui Li, Ruoyao Li, Hua Wang, Fei Wang. (2023) Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation. ADVANCED FUNCTIONAL MATERIALS, 33 (18): (2214059). [PMID:] [10.1002/adfm.202214059]
3. Ya Chen, Yuan Jiang, Xinyu Huang, Lin Chen, Hao Yang, Jian Zhao, Beibei Liang. (2022) Cordycepin Inhibits the Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic Glycolysis. Evidence-based Complementary and Alternative Medicine, 2022 (6454482). [PMID:36467556] [10.1155/2022/6454482]
4. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang. (2022) Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans. Infection and Drug Resistance, [PMID:33574683] [10.2147/IDR.S285690]
5. Weng Chunyue, Mi Zheyan, Li Meijing, Qin Haibin, Hu Zhongce, Liu Zhiqiang, Zheng Yuguo, Wang Yuanshan. (2022) Improvement of S-adenosyl-L-methionine production in Saccharomyces cerevisiae by atmospheric and room temperature plasma-ultraviolet compound mutagenesis and droplet microfluidic adaptive evolution. 3 Biotech, 12 (9): (1-15). [PMID:35975026] [10.1007/s13205-022-03297-x]
6. Huizhen Sun, Anyong Zhang, Yanchun Gong, Wei Sun, Baiyi Yan, Shuihong Lei, Li-Hua Yao. (2022) Improving effect of cordycepin on insulin synthesis and secretion in normal and oxidative-damaged INS-1 cells. EUROPEAN JOURNAL OF PHARMACOLOGY, 920 (174843). [PMID:35196519] [10.1016/j.ejphar.2022.174843]
7. Jing Yang, Yiwen Zhou, Jinsong Shi. (2020) Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK. LIFE SCIENCES, 251 (117645). [PMID:32268154] [10.1016/j.lfs.2020.117645]
8. Hao Song, Li-Ping Huang, Yuping Li, Chao Liu, Songhua Wang, Wei Meng, Shanshan Wei, Xin-Ping Liu, Yanchun Gong, Li-Hua Yao. (2018) Neuroprotective effects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons. NEUROTOXICOLOGY, 68 (73). [PMID:30031108] [10.1016/j.neuro.2018.07.008]

References

1. Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao. (2023) Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway. BIOMEDICINE & PHARMACOTHERAPY, 163 (114776). [PMID:37100012] [10.1016/j.biopha.2023.114776]
2. Xinyue Li, Yuanyuan Fan, Zhengbao Zha, Deyan Gong, Jiajia Yu, Qianhui Li, Ruoyao Li, Hua Wang, Fei Wang. (2023) Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation. ADVANCED FUNCTIONAL MATERIALS, 33 (18): (2214059). [PMID:] [10.1002/adfm.202214059]
3. Ya Chen, Yuan Jiang, Xinyu Huang, Lin Chen, Hao Yang, Jian Zhao, Beibei Liang. (2022) Cordycepin Inhibits the Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic Glycolysis. Evidence-based Complementary and Alternative Medicine, 2022 (6454482). [PMID:36467556] [10.1155/2022/6454482]
4. Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang. (2022) Evaluation of Anti-Biofilm Capability of Cordycepin Against Candida albicans. Infection and Drug Resistance, [PMID:33574683] [10.2147/IDR.S285690]
5. Weng Chunyue, Mi Zheyan, Li Meijing, Qin Haibin, Hu Zhongce, Liu Zhiqiang, Zheng Yuguo, Wang Yuanshan. (2022) Improvement of S-adenosyl-L-methionine production in Saccharomyces cerevisiae by atmospheric and room temperature plasma-ultraviolet compound mutagenesis and droplet microfluidic adaptive evolution. 3 Biotech, 12 (9): (1-15). [PMID:35975026] [10.1007/s13205-022-03297-x]
6. Huizhen Sun, Anyong Zhang, Yanchun Gong, Wei Sun, Baiyi Yan, Shuihong Lei, Li-Hua Yao. (2022) Improving effect of cordycepin on insulin synthesis and secretion in normal and oxidative-damaged INS-1 cells. EUROPEAN JOURNAL OF PHARMACOLOGY, 920 (174843). [PMID:35196519] [10.1016/j.ejphar.2022.174843]
7. Jing Yang, Yiwen Zhou, Jinsong Shi. (2020) Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK. LIFE SCIENCES, 251 (117645). [PMID:32268154] [10.1016/j.lfs.2020.117645]
8. Hao Song, Li-Ping Huang, Yuping Li, Chao Liu, Songhua Wang, Wei Meng, Shanshan Wei, Xin-Ping Liu, Yanchun Gong, Li-Hua Yao. (2018) Neuroprotective effects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons. NEUROTOXICOLOGY, 68 (73). [PMID:30031108] [10.1016/j.neuro.2018.07.008]

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Cordycepin - 98%, high purity , CAS No.73-03-0

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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