Corticosterone is a hormone synthesized in response to stress. It binds and activates MCRs(mineralocorticoid receptors) and GRs (glucocorticoid receptors), which results in altered expression. This eventually affects ionic conductances through the membran
Shipped In
Normal
Grade
analytical standard, Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Glucocorticoid receptor;Agonist of Mineralocorticoid receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Zhang B et al.. (2020) Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling.. J Neuroinflammation, 17 (318). [PMID:33100225]
2.Perry RJ et al.. (2015) Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.. Cell, 160 (4):(745-758). [PMID:25662011]
3.Gao C et al.. (2022) Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling.. Front Cell Dev Biol, 10 (731831). [PMID:35478969]
4.Li M et al.. (2017) Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach.. J Neurogastroenterol Motil, 23 (3):(464-476). [PMID:28343377]
5.Zhang B et al.. (2021) The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors.. Front Pharmacol, 12 (713715). [PMID:34381366]
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