Basic Description

Synonyms	cortistatin14 \| 193829-96-8 \| cortistatin \| Cortistatin-14 \| Cortistatin 14, human, rat \| 186901-48-4 \| Cortistatin-14 (trifluoroacetate salt) \| CST-14 \| Cortistatin 14 \| Corticostatin-14 \| CHEMBL5192321 \| BDBM85324 \| DTXSID00583202 \| PUBCHEM_16133803 \| HY-P1212 \| Cortistatin-14, >=97
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.Endogenous neuropeptide, expressed in the cortex and hippocampus. Structural and functional similarities to
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2–13]

Associated Targets(Human)

MRGPRX2 Tchem Mas-related G-protein coupled receptor member X2 (67 Activities)

Discover Target: MRGPRX2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mrgprb2 Mas-related G-protein coupled receptor member B2 (3 Activities)

Discover Target: Mrgprb2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-6-amino-2-[[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-16-[(1R)-1-hydroxyethyl]-7,10-bis(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-37-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carbonyl]amino]hexanoic acid
INCHI	InChI=1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1
InChi Key	DDRPLNQJNRBRNY-WYYADCIBSA-N
Canonical SMILES	CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O
Isomeric SMILES	C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)[C@@H]6CCCN6)C(=O)N[C@@H](CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O
WGK Germany	3
PubChem CID	16133803
Molecular Weight	1721.01

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

WGK Germany	3

Citations of This Product

1. Yuanyuan Ding, Tianyou Ma, Yonghui Zhang, Chenrui Zhao, Chao Wang, Zhao Wang. (2023) Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2/PLCγ1 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 117 (110003). [PMID:36931000]
2. Yilei Guo, Dandan Sun, Yajing Zhang, Xiaoxiao Yu, Yulai Fang, Changjun Lv, Qin Zhang, Yanrong Zhu, Simiao Qiao, Yufeng Xia, Zhifeng Wei, Yue Dai. (2022) The neuropeptide cortistatin attenuates Th17 cell response through inhibition of glycolysis via GHSR1. INTERNATIONAL IMMUNOPHARMACOLOGY, 108 (108843). [PMID:35598399]

References

1. Yuanyuan Ding, Tianyou Ma, Yonghui Zhang, Chenrui Zhao, Chao Wang, Zhao Wang. (2023) Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2/PLCγ1 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 117 (110003). [PMID:36931000]
2. Yilei Guo, Dandan Sun, Yajing Zhang, Xiaoxiao Yu, Yulai Fang, Changjun Lv, Qin Zhang, Yanrong Zhu, Simiao Qiao, Yufeng Xia, Zhifeng Wei, Yue Dai. (2022) The neuropeptide cortistatin attenuates Th17 cell response through inhibition of glycolysis via GHSR1. INTERNATIONAL IMMUNOPHARMACOLOGY, 108 (108843). [PMID:35598399]

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SKU	Size	Availability	Price	Qty
C118800-2.5mg	2.5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,682.90
C118800-500μg	500μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$564.90

Cortistatin 14 - ≥97% (HPLC), high purity , CAS No.186901-48-4