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Cortistatin 14, CAS No.193829-96-8
Endogenous neuropeptide; binds sst1- sst5, ghrelin receptor and MRGPRX2
Basic Description Product Name Cortistatin 14, CAS No.193829-96-8 Synonyms Cortistatin 14 | PUBCHEM_16133803 | Cortistatin-14, >=97% (HPLC) | CST-14 | cortistatin | AKOS024457590 | DTXSID00583202 | CS-0029008 | HY-P1212 | Cortistatin 14, human, rat | CAS_186901-48-4 | Cortistatin-14 (trifluoroacetate salt) | Corticostatin-14 | B Biochemical and Physiological Mechanisms Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1- sst5) and prevents somatostatin-14 binding (IC50values are 5 Sequence PCKNFFWKTFSSCK(Modifications: Disulfide bridge between 2 - 13)
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Product Specifications Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads CAS 193829-96-8
Citations of This Product 1. Yuanyuan Ding, Tianyou Ma, Yonghui Zhang, Chenrui Zhao, Chao Wang, Zhao Wang. (2023) Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2/PLCγ1 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 117 (110003). [PMID:36931000 ] [10.1016/j.intimp.2023.110003 ] 2. Yilei Guo, Dandan Sun, Yajing Zhang, Xiaoxiao Yu, Yulai Fang, Changjun Lv, Qin Zhang, Yanrong Zhu, Simiao Qiao, Yufeng Xia, Zhifeng Wei, Yue Dai. (2022) The neuropeptide cortistatin attenuates Th17 cell response through inhibition of glycolysis via GHSR1. INTERNATIONAL IMMUNOPHARMACOLOGY, 108 (108843). [PMID:35598399 ] [10.1016/j.intimp.2022.108843 ]
References 1. Yuanyuan Ding, Tianyou Ma, Yonghui Zhang, Chenrui Zhao, Chao Wang, Zhao Wang. (2023) Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2/PLCγ1 signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 117 (110003). [PMID:36931000 ] [10.1016/j.intimp.2023.110003 ] 2. Yilei Guo, Dandan Sun, Yajing Zhang, Xiaoxiao Yu, Yulai Fang, Changjun Lv, Qin Zhang, Yanrong Zhu, Simiao Qiao, Yufeng Xia, Zhifeng Wei, Yue Dai. (2022) The neuropeptide cortistatin attenuates Th17 cell response through inhibition of glycolysis via GHSR1. INTERNATIONAL IMMUNOPHARMACOLOGY, 108 (108843). [PMID:35598399 ] [10.1016/j.intimp.2022.108843 ]
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