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CP-101,606 - 98% (HPLC), high purity , Glutamate NMDA receptor; GRIN1/GRIN2B antagonist, CAS No.134234-12-1, Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
Basic Description
| Synonyms | CP 101606 | CS-W018847 | MLS006010672 | 1-[(S)-2-(S)-Hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-4-phenyl-piperidin-4-ol | BCP13195 | CP101606 | AKOS015959795 | Traxoprodil [INN] | DTXSID90158605 | TRAXOPRODIL [WHO-DD] | 134234-12-1 (free base) | Benzoph |
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| Specifications & Purity | Moligand™, ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | 曲索普地尔（CP-101606）是一种有效的N-甲基-D-天冬氨酸（NMDA）受体非竞争性拮抗剂，对NR2B亚单位具有选择性。在脑损伤和中风的动物模型中，它被证明具有神经保护作用。
CP-101606（曲索普地尔）在抑制谷氨酸诱导的大鼠死亡中起作用。它可能对人类缺血和神经退行性疾病有治疗作用。曲索普地尔由细胞色素P450（CYP）2D6代谢。 |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | ANTAGONIST |
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| Mechanism of action | Glutamate NMDA receptor; GRIN1/GRIN2B antagonist |
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| Product Description | CP-101,606 has been used as a N-methyl-D-aspartate (NMDA) receptor antagonist to study its role in recovery of spinal cord injuries.
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 1-[(1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol |
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| INCHI | InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1 |
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| InChi Key | QEMSVZNTSXPFJA-HNAYVOBHSA-N |
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| Canonical SMILES | CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O |
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| Isomeric SMILES | C[C@@H]([C@H](C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O |
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| WGK Germany | 3 |
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| PubChem CID | 219101 |
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| Molecular Weight | 327.42 |
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Chemical and Physical Properties
| Solubility | DMSO: ≥35 mg/mL |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS06, GHS09, GHS07 |
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| Signal | Danger |
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| Hazard Statements | H319:Causes serious eye irritation H301:Toxic if swallowed H400:Very toxic to aquatic life |
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| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. |
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| WGK Germany | 3 |
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