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G protein-coupled receptors (GPCRs)
Corticotropin-releasing factor receptors
CP-316,311 , CAS No.C609568, Antagonist of CRF 1 receptor

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CP-316,311 , CAS No.C609568, Antagonist of CRF 1 receptor

Moligand™

PubChem CID: 9818802

Item Number

C609568

Grouped product items
SKU	Size	Availability	Price	Qty
C609568-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$370.90
C609568-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90

View related series

CRF1 receptor Antagonist

Basic Description

Synonyms	175139-41-0 \| CP-316311 \| CP 316311 \| Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)- \| GNW87JO5PF \| 4-(1-ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine \| UNII-GNW87JO5PF \| CP-316,311 \| 3,6-dimethyl-4-pentan-3-yloxy-2-(2,4,6-trimet
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CRF 1 receptor

Associated Targets(Human)

CRHR1 Tclin Corticotropin-releasing factor receptor 1 (3 Activities)

Discover Target: CRHR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)

Discover Target: CRHR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Canis familiaris (36305 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3,6-dimethyl-4-pentan-3-yloxy-2-(2,4,6-trimethylphenoxy)pyridine
INCHI	InChI=1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3
InChi Key	ZSEJGVQTBLJRCQ-UHFFFAOYSA-N
Canonical SMILES	CCC(Oc1cc(C)nc(c1C)Oc1c(C)cc(cc1C)C)CC
Isomeric SMILES	CCC(CC)OC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C
PubChem CID	9818802

Database links

PubChem CID	9818802
ChEMBL Ligand	CHEMBL270738
BindingDB Ligand	20933
GPCRdb Ligand	CP-316,311

Certificates

Certificate of Analysis(COA)

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References

1. Chen YL, Braselton J, Forman J, Gallaschun RJ, Mansbach R, Schmidt AW, Seeger TF, Sprouse JS, Tingley 3rd FD, Winston E et al.. (2008) Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists.. J Med Chem, 51 (5): (1377-84). [PMID:18260619] [10.1021/op500134e]

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