CP 424174 - ≥98%, high purity , CAS No.210825-31-3, Inhibitor of NLRP3

Item Number
C276195
Grouped product items
SKUSizeAvailabilityPrice Qty
C276195-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
C276195-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
C276195-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$179.90
C276195-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$259.90
C276195-250mg
250mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$499.90

IL-1β posttranslational processing inhibitor; indirectly inhibits NLRP3

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsA cytokine release inhibitory drug (CRID).\xa0IL-1β inhibitor of\xa0post-translational processing and secretion in response to LPS and ATP in human monocytes (IC 50 = 210nM). NLRP3 indirect inhibitor.
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of NLRP3
NoteRefer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Shipped at 4°C. Store at -20°C. Store In the Dark.

Associated Targets(Human)

NLRP3 Tchem NACHT, LRR and PYD domains-containing protein 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1-[4-chloro-2,6-di(propan-2-yl)phenyl]-3-[3-(2-hydroxypropan-2-yl)phenyl]sulfonylurea
INCHI InChI=1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26)
InChi Key YRSBLSHMKVQWHP-UHFFFAOYSA-N
Canonical SMILES CC(C)C1=CC(=CC(=C1NC(=O)NS(=O)(=O)C2=CC=CC(=C2)C(C)(C)O)C(C)C)Cl
Isomeric SMILES CC(C)C1=CC(=CC(=C1NC(=O)NS(=O)(=O)C2=CC=CC(=C2)C(C)(C)O)C(C)C)Cl
PubChem CID 9911728
Molecular Weight 452.99

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
L2314088Certificate of AnalysisSep 11, 2024 C276195
L2314089Certificate of AnalysisSep 11, 2024 C276195
L2314090Certificate of AnalysisSep 11, 2024 C276195
L2314091Certificate of AnalysisSep 11, 2024 C276195
L2314092Certificate of AnalysisSep 11, 2024 C276195
L2314085Certificate of AnalysisNov 30, 2023 C276195
L2314086Certificate of AnalysisNov 30, 2023 C276195
L2314087Certificate of AnalysisNov 30, 2023 C276195

Chemical and Physical Properties

SolubilityDMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

References

1. Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J, Griffiths R, Dombroski MA, Gabel CA.  (2001)  Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors..  J Pharmacol Exp Ther,  299  (1): (187-97).  [PMID:11561079] [10.1021/op500134e]
2. Fenini G, Contassot E, French LE.  (2017)  Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases..  Front Pharmacol,  (13): (278).  [PMID:28588486] [10.1021/op500134e]

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