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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C276195-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $79.90 | |
C276195-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $119.90 | |
C276195-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $179.90 | |
C276195-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $259.90 | |
C276195-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $499.90 |
IL-1β posttranslational processing inhibitor; indirectly inhibits NLRP3
Specifications & Purity | Moligand™, ≥98% |
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Biochemical and Physiological Mechanisms | A cytokine release inhibitory drug (CRID).\xa0IL-1β inhibitor of\xa0post-translational processing and secretion in response to LPS and ATP in human monocytes (IC 50 = 210nM). NLRP3 indirect inhibitor. |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of NLRP3 |
Note | Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Shipped at 4°C. Store at -20°C. Store In the Dark. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-[4-chloro-2,6-di(propan-2-yl)phenyl]-3-[3-(2-hydroxypropan-2-yl)phenyl]sulfonylurea |
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INCHI | InChI=1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26) |
InChi Key | YRSBLSHMKVQWHP-UHFFFAOYSA-N |
Canonical SMILES | CC(C)C1=CC(=CC(=C1NC(=O)NS(=O)(=O)C2=CC=CC(=C2)C(C)(C)O)C(C)C)Cl |
Isomeric SMILES | CC(C)C1=CC(=CC(=C1NC(=O)NS(=O)(=O)C2=CC=CC(=C2)C(C)(C)O)C(C)C)Cl |
PubChem CID | 9911728 |
Molecular Weight | 452.99 |
PubChem CID | 9911728 |
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ChEMBL Ligand | CHEMBL3781583 |
BindingDB Ligand | 50155923 |
CAS Registry No. | 210825-31-3 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2314088 | Certificate of Analysis | Sep 11, 2024 | C276195 |
L2314089 | Certificate of Analysis | Sep 11, 2024 | C276195 |
L2314090 | Certificate of Analysis | Sep 11, 2024 | C276195 |
L2314091 | Certificate of Analysis | Sep 11, 2024 | C276195 |
L2314092 | Certificate of Analysis | Sep 11, 2024 | C276195 |
L2314085 | Certificate of Analysis | Nov 30, 2023 | C276195 |
L2314086 | Certificate of Analysis | Nov 30, 2023 | C276195 |
L2314087 | Certificate of Analysis | Nov 30, 2023 | C276195 |
Solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml |
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RIDADR | NONHforallmodesoftransport |
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1. Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J, Griffiths R, Dombroski MA, Gabel CA. (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.. J Pharmacol Exp Ther, 299 (1): (187-97). [PMID:11561079] [10.1021/op500134e] |
2. Fenini G, Contassot E, French LE. (2017) Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases.. Front Pharmacol, 8 (13): (278). [PMID:28588486] [10.1021/op500134e] |