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CP-466722 - ≥98%, high purity , CAS No.1080622-86-1, Inhibitor of ATM serine/threonine kinase
Basic Description Synonyms 2-(6,7-Dimethoxy-quinazolin-4-yl)-5-pyridin-2-yl-2H-[1,2,4]triazol-3-ylamine | AC-28457 | BCP02229 | A25042 | CP466722, >=98% (HPLC) | HMS3265A19 | HMS3265B20 | CI 60710 | 2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine;CP-46672 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase. The compound CP466722 disrupts ATM-dependent checkpoint cell cylce events, and reverses ATM-dependent substrate phosphorylation and downstream signaling ev Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of ATM serine/threonine kinase Product Description CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine INCHI InChI=1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H,1-2H3,(H2,18,22,23) InChi Key ILBRKJBKDGCSCB-UHFFFAOYSA-N Canonical SMILES COC1=C(C=C2C(=C1)C(=NC=N2)N3C(=NC(=N3)C4=CC=CC=N4)N)OC Isomeric SMILES COC1=C(C=C2C(=C1)C(=NC=N2)N3C(=NC(=N3)C4=CC=CC=N4)N)OC WGK Germany 3 PubChem CID 44551660 Molecular Weight 349.35
Chemical and Physical Properties Solubility DMSO 0.28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3
References 1. Rainey MD, Charlton ME, Stanton RV, Kastan MB. (2008) Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res, 68 (18): (7466-74). [PMID:18794134 ]
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