CP-671305 - 98%, high purity , CAS No.445295-04-5

  • ≥98%
Item Number
C412193
Grouped product items
SKUSizeAvailabilityPrice Qty
C412193-5mg
5mg
In stock
$98.90
C412193-10mg
10mg
In stock
$147.90
C412193-25mg
25mg
In stock
$246.90
C412193-50mg
50mg
In stock
$444.90

PDE4 Selective Inhibitors

Basic Description

SynonymsNCGC00248048-01 | 9LH034R9R9 | CAS-445295-04-5 | CCG-15109 | CNIGFESSDPOCKS-CYBMUJFWSA-N | SCHEMBL2154519 | AKOS040758617 | DTXCID4027282 | UNII-9LH034R9R9 | CP671305 | CP-671305 | (R)-2-(4-((2-(benzo[d][1,3]dioxol-5-yloxy)nicotinamido)methyl)-3-fluorophe
Specifications & Purity≥98%
Biochemical and Physiological MechanismsCP-671305 is a potent, selective and orally active inhibitor of phosphodiesterase-4-D (PDE4-D) with IC50 of 3 nM.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

CP-671305 is a potent, selective and orally active inhibitor ofphosphodiesterase-4-D (PDE4-D)with IC50 of 3 nM.


Targets

PDE4-D (Cell-free assay) 3 nM

Product Properties

ALogP3.493
HBD Count1
Rotatable Bond8

Associated Targets(Human)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE4B Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4B Tclin Phosphodiesterase 4B (2748 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R)-2-[4-[[[2-(1,3-benzodioxol-5-yloxy)pyridine-3-carbonyl]amino]methyl]-3-fluorophenoxy]propanoic acid
INCHI InChI=1S/C23H19FN2O7/c1-13(23(28)29)32-15-5-4-14(18(24)9-15)11-26-21(27)17-3-2-8-25-22(17)33-16-6-7-19-20(10-16)31-12-30-19/h2-10,13H,11-12H2,1H3,(H,26,27)(H,28,29)/t13-/m1/s1
InChi Key CNIGFESSDPOCKS-CYBMUJFWSA-N
Canonical SMILES CC(C(=O)O)OC1=CC(=C(C=C1)CNC(=O)C2=C(N=CC=C2)OC3=CC4=C(C=C3)OCO4)F
Isomeric SMILES C[C@H](C(=O)O)OC1=CC(=C(C=C1)CNC(=O)C2=C(N=CC=C2)OC3=CC4=C(C=C3)OCO4)F
PubChem CID 9955578
Molecular Weight 454.4

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
K2215536Certificate of AnalysisAug 12, 2022 C412193
K2215537Certificate of AnalysisAug 12, 2022 C412193
K2215538Certificate of AnalysisAug 12, 2022 C412193
K2215739Certificate of AnalysisAug 12, 2022 C412193

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 91 mg/mL (200.26 mM); Ethanol: 20 mg/mL (44.01 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility91
DMSO(mM) Max Solubility200.264084507042
Water(mg / mL) Max Solubility<1

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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