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CP376395 - 98%, high purity , CAS No.175140-00-8, Antagonist of CRF 1 receptor
Basic Description Synonyms VIZBSVDBNLAVAW-UHFFFAOYSA-N | BDBM20966 | 5113G7FP34 | UNII-5113G7FP34 | compound 3a [PMID: 18288792] | GTPL3496 | 3,6-Dimethyl-N-(Pentan-3-Yl)-2-(2,4,6-Trimethylphenoxy)pyridin-4-Amine | AKOS015994585 | CP-376,395 | 4k5y | CP 376395 | GD-0065 | CP-376395 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms CP 376395 is a potent and selective antagonist of corticotropin releasing factor 1 (CRF1) receptor.
CP-376395 is a potent and selective antagonist of the CRF1 receptor, which has been shown to play an important role in mediating behavioral and endocrine r Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of CRF 1 receptor Product Description Information
CP376395 CP 376395 is a potent and selective antagonist of corticotropin releasing factor 1 (CRF1) receptor.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3,6-dimethyl-N-pentan-3-yl-2-(2,4,6-trimethylphenoxy)pyridin-4-amine INCHI InChI=1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23) InChi Key VIZBSVDBNLAVAW-UHFFFAOYSA-N Canonical SMILES CCC(CC)NC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C Isomeric SMILES CCC(CC)NC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C PubChem CID 9862166 Molecular Weight 326.49
Chemical and Physical Properties Solubility Solubility (25°C) In vitro Ethanol: mg/mL
References 1. Chen YL, Obach RS, Braselton J, Corman ML, Forman J, Freeman J, Gallaschun RJ, Mansbach R, Schmidt AW, Sprouse JS et al. . (2008) 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.. J Med Chem, 51 (5): (1385-92). [PMID:18288792 ] [10.1021/op500134e ]
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B2308494