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CRAC channel inhibitor 1 , CAS No.C609598, Channel blocker of Orai1

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CRAC channel inhibitor 1 , CAS No.C609598, Channel blocker of Orai1

Moligand™

PubChem CID: 3509452

Item Number

C609598

Grouped product items
SKU	Size	Availability	Price	Qty
C609598-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C609598-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

Orai1 Channel blocker

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of Orai1

Associated Targets(Human)

ORAI1 Tchem Calcium release-activated calcium channel protein 1 (0 Activities)

Discover Target: ORAI1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV1 Tclin Vanilloid receptor (8273 Activities)

Discover Target: TRPV1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CACNA1B Tclin Voltage-gated N-type calcium channel alpha-1B subunit (743 Activities)

Discover Target: CACNA1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ORAI1 Tchem Calcium release-activated calcium channel protein 1 (150 Activities)

Discover Target: ORAI1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Trpm8 Transient receptor potential cation channel subfamily M member 8 (889 Activities)

Discover Target: Trpm8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3-(4-chlorophenyl)-1-[1-(4-methylphenyl)propyl]urea
INCHI	InChI=1S/C17H19ClN2O/c1-3-16(13-6-4-12(2)5-7-13)20-17(21)19-15-10-8-14(18)9-11-15/h4-11,16H,3H2,1-2H3,(H2,19,20,21)
InChi Key	FKBYZUDELOWDJW-UHFFFAOYSA-N
Canonical SMILES	CCC(c1ccc(cc1)C)NC(=O)Nc1ccc(cc1)Cl
Isomeric SMILES	CCC(C1=CC=C(C=C1)C)NC(=O)NC2=CC=C(C=C2)Cl
PubChem CID	3509452

Database links

PubChem CID	3509452
ChEMBL Ligand	CHEMBL3923438

Certificates

Certificate of Analysis(COA)

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References

1. Zhang HZ, Xu XL, Chen HY, Ali S, Wang D, Yu JW, Xu T, Nan FJ. (2015) Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel.. Acta Pharmacol Sin, 36 (9): (1137-44). [PMID:26256403]

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