Cromakalim - ≥99%, high purity , CAS No.94470-67-4, Activator of K ir6.1;Activator of K ir6.2;Channel blocker of K v1.7;Channel blocker of K v3.1

Item Number
C274992
Grouped product items
SKUSizeAvailabilityPrice Qty
C274992-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$194.90
C274992-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$801.90

K IR 6.x (K ATP ) channel activator

Basic Description

SynonymsGTPL2413 | (+/-)-cromakalim | 2H-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)- | F82193 | BRD-A76093993-001-01-8 | AKOS030255268 | Cycloheptyl dipropylamidocyanidophosphate | 2H-1-BENZOPYRAN-6-CARBONITRILE, 3,4-DI
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsK IR 6.x (K ATP ) channel activator. Orally active, potent smooth muscle relaxant.
Storage TempStore at 2-8°C,Desiccated
Shipped InWet ice
GradeMoligand™
Action TypeACTIVATOR, CHANNEL BLOCKER
Mechanism of actionActivator of K ir6.1;Activator of K ir6.2;Channel blocker of K v1.7;Channel blocker of K v3.1
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

KCNA7 Tclin Potassium voltage-gated channel subfamily A member 7 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNC1 Tclin Potassium voltage-gated channel subfamily C member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNJ8 Tbio ATP-sensitive inward rectifier potassium channel 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNJ11 Tclin ATP-sensitive inward rectifier potassium channel 11 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABCC9 Tclin Sulfonylurea receptor 2 (109 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNJ11 Tclin Sulfonylurea receptors; K-ATP channels (596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sus scrofa (849 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A10 (235 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATP5F1E Mitochondrial complex V; ATP synthase (114 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Heart (171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aorta (2975 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Thoracic (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Thoracic aorta (838 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile
INCHI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3
InChi Key TVZCRIROJQEVOT-UHFFFAOYSA-N
Canonical SMILES CC1(C(C(C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C
Isomeric SMILES CC1(C(C(C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C
PubChem CID 443423
Molecular Weight 286.33

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 50 mM

Related Documents

Solution Calculators