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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | (3R,4R,5R,8a1R,13aR)-4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,8a1,10,12,13,13a-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione | KBio2_004272 | rel-(3R,4R,5R,8a1R,13aR)-4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,8a1,10,12,13,13a-octahydro-2H-[ |
|---|---|
| Specifications & Purity | ≥95% |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Monocrotaline is a toxic, pyrrolizidine alkaloid. It is used for inducing pulmonary diseases in rats. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. |
Associated Targets(Human)
GMNN Tbio Geminin (0 Activities)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
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ACHE Tclin Acetylcholinesterase (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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THRB Tclin Thyroid hormone receptor beta (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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BCHE Tclin Cholinesterase (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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TP53 Tchem Cellular tumor antigen p53 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ACHE Tclin Acetylcholinesterase (18204 Activities)
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THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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A204 (242 Activities)
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KB (17409 Activities)
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
GMNN Tbio Geminin (128009 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
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Associated Targets(non-human)
pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
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ampC Beta-lactamase AmpC (62480 Activities)
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Pseudomonas aeruginosa (123386 Activities)
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Escherichia coli (133304 Activities)
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Spodoptera littoralis (798 Activities)
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Meloidogyne incognita (862 Activities)
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Rattus norvegicus (775804 Activities)
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Myzus persicae (1112 Activities)
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CHO (4503 Activities)
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Lactuca sativa (1092 Activities)
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BCHE Cholinesterase (8742 Activities)
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Leptinotarsa decemlineata (1161 Activities)
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Rhopalosiphum padi (121 Activities)
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Pratylenchus penetrans (14 Activities)
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Heterodera schachtii (22 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Phasmarhabditis hermaphrodita (5 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Rhabditis sp. (25 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SARS-CoV-2 (38078 Activities)
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Names and Identifiers
| Pubchem Sid | 488180976 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180976 |
| IUPAC Name | (1R,4R,5R,6R,16R)-5,6-dihydroxy-4,5,6-trimethyl-2,8-dioxa-13-azatricyclo[8.5.1.013,16]hexadec-10-ene-3,7-dione |
| INCHI | InChI=1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1 |
| InChi Key | QVCMHGGNRFRMAD-XFGHUUIASA-N |
| Canonical SMILES | CC1C(=O)OC2CCN3C2C(=CC3)COC(=O)C(C1(C)O)(C)O |
| Isomeric SMILES | C[C@H]1C(=O)O[C@@H]2CCN3[C@@H]2C(=CC3)COC(=O)[C@]([C@]1(C)O)(C)O |
| WGK Germany | 3 |
| RTECS | QB3140000 |
| PubChem CID | 9415 |
| UN Number | 1544 |
| Molecular Weight | 325.36 |
| Beilstein | 48732 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2208274 | Certificate of Analysis | Sep 03, 2024 | C101556 |
| K2208275 | Certificate of Analysis | Sep 03, 2024 | C101556 |
| F2414388 | Certificate of Analysis | Jun 22, 2024 | C101556 |
| F2414389 | Certificate of Analysis | Jun 22, 2024 | C101556 |
| E2406069 | Certificate of Analysis | Jan 03, 2024 | C101556 |
| L2325149 | Certificate of Analysis | Jan 03, 2024 | C101556 |
| L2325150 | Certificate of Analysis | Jan 03, 2024 | C101556 |
| I2307209 | Certificate of Analysis | Sep 18, 2023 | C101556 |
| I2307238 | Certificate of Analysis | Sep 18, 2023 | C101556 |
| C2318982 | Certificate of Analysis | Apr 10, 2023 | C101556 |
| C2318986 | Certificate of Analysis | Apr 10, 2023 | C101556 |
| C2318988 | Certificate of Analysis | Apr 10, 2023 | C101556 |
| C2318995 | Certificate of Analysis | Apr 09, 2023 | C101556 |
| C2318996 | Certificate of Analysis | Apr 09, 2023 | C101556 |
| C2318998 | Certificate of Analysis | Apr 09, 2023 | C101556 |
| G1813016 | Certificate of Analysis | May 09, 2022 | C101556 |
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Chemical and Physical Properties
| Melt Point(°C) | 204°C |
|---|
Safety and Hazards(GHS)
Related Documents
Citations of This Product
| 1. Haixia Che, Jie Yi, Xiaoting Zhao, Hong Yu, Xianyao Wang, Rui Zhang, Xin Li, Jia Fu, Qian Li. (2023) Characterization of PKCα-rutin interactions and its application as a treatment strategy for PAH by inhibiting ferroptosis. Food & Function, [PMID:38126185] |
| 2. Yanhui Ge, Shuchang Zhao, Boyi Yuan, Yuan Gao, Ruilin Liu. (2023) In-situ growth of metal coordination-synergistic imprinted polymer onto shrimp shell-derived magnetic FeNi biochar for specific recognition of monocrotaline in herbal medicine. Materials Today Sustainability, 24 (16): (100599). [PMID:3426601] |
| 3. Yang Zhong, Jiayu Gu, Yaoquan Su, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng. (2022) Real-time screening of hepatotoxins in natural medicine by peroxynitrite responsive lanthanide-based NIR-II luminescent probes. CHEMICAL ENGINEERING JOURNAL, 433 (133263). [PMID:] |
References
| 1. Haixia Che, Jie Yi, Xiaoting Zhao, Hong Yu, Xianyao Wang, Rui Zhang, Xin Li, Jia Fu, Qian Li. (2023) Characterization of PKCα-rutin interactions and its application as a treatment strategy for PAH by inhibiting ferroptosis. Food & Function, [PMID:38126185] |
| 2. Yanhui Ge, Shuchang Zhao, Boyi Yuan, Yuan Gao, Ruilin Liu. (2023) In-situ growth of metal coordination-synergistic imprinted polymer onto shrimp shell-derived magnetic FeNi biochar for specific recognition of monocrotaline in herbal medicine. Materials Today Sustainability, 24 (16): (100599). [PMID:3426601] |
| 3. Yang Zhong, Jiayu Gu, Yaoquan Su, Lingzhi Zhao, Yunyun Zhou, Juanjuan Peng. (2022) Real-time screening of hepatotoxins in natural medicine by peroxynitrite responsive lanthanide-based NIR-II luminescent probes. CHEMICAL ENGINEERING JOURNAL, 433 (133263). [PMID:] |