Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C101973-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $37.90 | |
C101973-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $147.90 |
Synonyms | BDBM57938 | Cryptotanshinon;Tanshinone c | MLS001049002 | NCGC00159505-02 | 1-Monolaurin;1-Lauroyl-rac-glycerol | EN300-7416850 | NCGC00163650-01 | Tanshinone c | BCP02909 | BCP9000554 | DB15579 | Phenanthro[1,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimeth |
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Specifications & Purity | analytical standard, ≥98% |
Storage Temp | Store at 2-8°C,Protected from light |
Shipped In | Wet ice |
Grade | analytical standard |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione |
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INCHI | InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1 |
InChi Key | GVKKJJOMQCNPGB-JTQLQIEISA-N |
Canonical SMILES | CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C |
Isomeric SMILES | C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C |
WGK Germany | 3 |
RTECS | SF8282645 |
PubChem CID | 160254 |
Molecular Weight | 296.36 |
Beilstein | 5445400 |
Reaxy-Rn | 5445400 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2412010 | Certificate of Analysis | Jul 18, 2024 | C101973 |
I2114109 | Certificate of Analysis | Jun 13, 2023 | C101973 |
C2302274 | Certificate of Analysis | Nov 24, 2022 | C101973 |
C2302292 | Certificate of Analysis | Nov 24, 2022 | C101973 |
A2125309 | Certificate of Analysis | Nov 11, 2022 | C101973 |
Sensitivity | Light & Moisture sensitive. |
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Specific Rotation[α] | -30° (C=0.5,MeOH) |
Melt Point(°C) | 184°C-185°C |
Pictogram(s) | GHS06, GHS09 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P273:Avoid release to the environment. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | SF8282645 |
Reaxy-Rn | 5445400 |
1. Jiahui Han Di Jia Hao Yao Ting Lv Xi Xu Xin Ge. (2023) Cryptotanshinone ameliorates hemorrhagic shock-induced liver injury via activating the Nrf2 signaling pathway. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 61 (2): (109-122). [PMID:37435898] [10.5603/FHC.a2023.0009] |
2. He Xiangjun, Zhong Zhi, Wang Quan, Jia Zhenmao, Lu Jing, Chen Jianwen, Liu Peiqing. (2023) Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone. Frontiers in Pharmacology, 14 [PMID:36969870] [10.3389/fphar.2023.1127219] |
3. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. (2022) A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. METABOLIC ENGINEERING, 73 (182). [PMID:35934177] [10.1016/j.ymben.2022.08.002] |
4. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 [PMID:35910733] [10.3389/fchem.2022.964744] |
5. Huan Wang, Zhe Liu, Lingnan Guan, Jiankang Li, Siyi Chen, Wenying Yu, Maode Lai. (2020) LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis. PHARMACOLOGICAL RESEARCH, 153 (104661). [PMID:31982491] [10.1016/j.phrs.2020.104661] |
6. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai. (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. PLANT SCIENCE, 284 (1). [PMID:31084862] [10.1016/j.plantsci.2019.03.007] |
7. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. (2017) Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs). PHARMACEUTICAL BIOLOGY, [PMID:28466663] [10.3109/13880209.2015.1045621] |
8. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen. (2016) Ball mill assisted rapid mechanochemical extraction method for natural products from plants. JOURNAL OF CHROMATOGRAPHY A, 1449 (8). [PMID:27157426] [10.1016/j.chroma.2016.04.044] |
9. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin. (2016) Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins. Scientific Reports, 6 (1): (1-11). [PMID:26875847] [10.1038/srep20919] |
10. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai. (2016) Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64 (12): (2523–2530). [PMID:26753746] [10.1021/acs.jafc.5b04697] |
11. Ming Cong, Cui-Min Hu, Yun-Feng Cao, Zhong-Ze Fang, Shu-Hong Tang, Jia-Rui Wang, Jun-Sheng Luo. (2013) Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation. FITOTERAPIA, 85 (109). [PMID:23333907] [10.1016/j.fitote.2013.01.002] |
1. Jiahui Han Di Jia Hao Yao Ting Lv Xi Xu Xin Ge. (2023) Cryptotanshinone ameliorates hemorrhagic shock-induced liver injury via activating the Nrf2 signaling pathway. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 61 (2): (109-122). [PMID:37435898] [10.5603/FHC.a2023.0009] |
2. He Xiangjun, Zhong Zhi, Wang Quan, Jia Zhenmao, Lu Jing, Chen Jianwen, Liu Peiqing. (2023) Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone. Frontiers in Pharmacology, 14 [PMID:36969870] [10.3389/fphar.2023.1127219] |
3. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. (2022) A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. METABOLIC ENGINEERING, 73 (182). [PMID:35934177] [10.1016/j.ymben.2022.08.002] |
4. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 [PMID:35910733] [10.3389/fchem.2022.964744] |
5. Huan Wang, Zhe Liu, Lingnan Guan, Jiankang Li, Siyi Chen, Wenying Yu, Maode Lai. (2020) LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis. PHARMACOLOGICAL RESEARCH, 153 (104661). [PMID:31982491] [10.1016/j.phrs.2020.104661] |
6. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai. (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. PLANT SCIENCE, 284 (1). [PMID:31084862] [10.1016/j.plantsci.2019.03.007] |
7. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. (2017) Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs). PHARMACEUTICAL BIOLOGY, [PMID:28466663] [10.3109/13880209.2015.1045621] |
8. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen. (2016) Ball mill assisted rapid mechanochemical extraction method for natural products from plants. JOURNAL OF CHROMATOGRAPHY A, 1449 (8). [PMID:27157426] [10.1016/j.chroma.2016.04.044] |
9. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin. (2016) Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins. Scientific Reports, 6 (1): (1-11). [PMID:26875847] [10.1038/srep20919] |
10. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai. (2016) Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64 (12): (2523–2530). [PMID:26753746] [10.1021/acs.jafc.5b04697] |
11. Ming Cong, Cui-Min Hu, Yun-Feng Cao, Zhong-Ze Fang, Shu-Hong Tang, Jia-Rui Wang, Jun-Sheng Luo. (2013) Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation. FITOTERAPIA, 85 (109). [PMID:23333907] [10.1016/j.fitote.2013.01.002] |