CSP-C Antibody - Primary antibody, specific to CSP-C, Rabbit IgG

    Application:
  • IHC
  • WB
Features and benefits
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human,Mouse
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab097978
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab097978-10μl
10μl
In stock
$66.90
Ab097978-50μl
50μl
In stock
$199.90
Ab097978-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab097978-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,799.90

pAb; Rabbit anti Human CSP-C Antibody; WB, IHC; Unconjugated

Basic Description

Product NameCSP-C Antibody - Primary antibody, specific to CSP-C, Rabbit IgG
SynonymsCSP-C | Cathepsin G-like 2 | CCP-X | CCP-Xcytotoxic T-lymphocyte-associated serine esterase 1 | CGL2 | CGL-2 | CSP-Ccytotoxin serine protease-C | CTLA1 | CTSGL2 | CTSGL2granzyme H | Cytotoxic serine protease C | Cytotoxic T-lymphocyte proteinase | EC 3.4.
Specifications & PurityExactAb™, Validated, Carrier Free, 1.8 mg/mL
Host speciesRabbit
SpecificityCSP-C
ImmunogenFusion protein of human GZMH (AA 97-243)
Positive ControlWB: HeLa, Raji, MCF7, MDA-MB-231 and NIH/3T3 cell lysates. IHC: Human esophagus cancer tissue.
ConjugationUnconjugated
GradeCarrier Free, ExactAb™, Validated
Product Description

Rabbit anti Human CSP-C Antibody, Polyclonal, could be used for WB, IHC and so on.

Application

WB: 1/500-1/1000

IHC: 1/50-1/100

Protein Function

Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration1.8 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

CSP-C Antibody (Ab097978) - Western Blot
All lanes: CSP-C Antibody (Ab097978) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 27 kDa
Observed band size: 24 kDa
Exposure time: 114.7 s


CSP-C Antibody (Ab097978) - IHC
Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer using CSP-C Antibody (Ab097978). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Associated Targets(Human)

GZMH Tbio Granzyme H (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB1/500-1/1000

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1/500-1/1000

IHC1/50 - 1/100

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1/50 - 1/100

Certificates

Certificate of Analysis(COA)

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2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0303209Certificate of AnalysisMar 14, 2024 Ab097978
ZJ24F0303208Certificate of AnalysisMar 14, 2024 Ab097978

Related Documents

References

1. Haddad, P P and 5 more authors..  (1991)  Structure and evolutionary origin of the human granzyme H gene..  International immunology,      [PMID:2049336]
2. Meier, M M and 9 more authors..  (1990)  Cloning of a gene that encodes a new member of the human cytotoxic cell protease family..  Biochemistry,    (1):   [PMID:2193684]
3. Klein, J L JL, Selvakumar, A A, Trapani, J A JA and Dupont, B B..  (1990)  Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)..  Tissue antigens,      [PMID:2402757]
4. Heilig, Roland R and 98 more authors..  (2003)  The DNA sequence and analysis of human chromosome 14..  Nature,    (6):   [PMID:12508121]
5. Wang, Li L and 8 more authors..  (2012)  Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif..  Journal of immunology (Baltimore, Md. : 1950),    (15):   [PMID:22156497]
6. Wang, Li L and 13 more authors..  (2013)  Identification of SERPINB1 as a physiological inhibitor of human granzyme H..  Journal of immunology (Baltimore, Md. : 1950),    (1):   [PMID:23269243]

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