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CU-CPT-8m - 99%, high purity , CAS No.125079-83-6, Inhibitor of TLR8
Basic Description Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms CU-CPT-8m (CPD1578) is a specific antagonist of toll-like receptor 8(TLR8) with IC50 of 67 nM and Kd of 220 nM. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of TLR8 Product Description Information
CU-CPT-8m CU-CPT-8m (CPD1578) is a specific antagonist of toll-like receptor 8(TLR8) with IC50 of 67 nM and Kd of 220 nM.
Targets
TLR8 (Cell-free assay); TLR8 (Cell-free assay) 67 nM; 220 nM(Ki)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide INCHI InChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19) InChi Key HNKGGVGQAVODNJ-UHFFFAOYSA-N Canonical SMILES CC1=CC(=CC=C1)C2=CC=NC3=C(C=NN23)C(=O)N Isomeric SMILES CC1=CC(=CC=C1)C2=CC=NC3=C(C=NN23)C(=O)N PubChem CID 15042086 Molecular Weight 252.27
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 6 mg/mL (23.78 mM); Water: Insoluble; Ethanol: Insoluble;
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
References 1. Zhang S, Hu Z, Tanji H, Jiang S, Das N, Li J, Sakaniwa K, Jin J, Bian Y, Ohto U et al. . (2018) Small-molecule inhibition of TLR8 through stabilization of its resting state.. Nat Chem Biol, 14 (1): (58-64). [PMID:29155428 ] [10.1021/op500134e ]
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K2211135