Potent TLR1/2 agonist (EC50= 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokinesin vitro. Also enhances TLR1 and TLR2 dimerization.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.
J2112267