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Curcumin analog C1 - 97%, high purity , CAS No.39777-61-2
Basic Description Synonyms (1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one|39777-61-2|TFEB activator 1|41973-42-6|RPN77612|Go-Y019|CHEMBL477053|1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one|NSC97906|SCHEMBL2744044|SCHEMBL2744047|TFEB activator 1; ABM-7612|BDBM50285603|MFCD00719 Specifications & Purity ≥97% Biochemical and Physiological Mechanisms TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway an Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
Curcumin analog C1 (Curcumin analog Compound C1) is a potenttranscription factor EB (TFEB)activator with promise for the prevention or treatment of Alzheimer's disease.
Names and Identifiers IUPAC Name (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one INCHI InChI=1S/C19H18O3/c1-21-18-9-5-3-7-15(18)11-13-17(20)14-12-16-8-4-6-10-19(16)22-2/h3-14H,1-2H3/b13-11+,14-12+ InChi Key RCZMPCUUTSDNAJ-PHEQNACWSA-N Canonical SMILES COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC Isomeric SMILES COC1=CC=CC=C1/C=C/C(=O)/C=C/C2=CC=CC=C2OC PubChem CID 830608 Molecular Weight 294.34
Chemical and Physical Properties Solubility DMSO: 59 mg/mL (200.45 mM)Ethanol: 2 mg/mL (6.79 mM)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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