Determine the necessary mass, volume, or concentration for preparing a solution.
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Basic Description
| Synonyms | curcumin|458-37-7|Diferuloylmethane|Natural yellow 3|Indian saffron|Kacha haldi|Curcuma|Gelbwurz|Haldar|Curcumin I|Souchet|Haidr|Halad|Halud|Yellow Ginger|Terra Merita|(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione|Safran d'Inde|Yo-Ki |
|---|---|
| Specifications & Purity | ≥65% |
| Biochemical and Physiological Mechanisms | A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and i |
| Storage Temp | Store at -20°C,Argon charged |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Associated Targets
CYP3A4 Tclin Cytochrome P450 3A4 0 Activities
EP300 Tchem Histone acetyltransferase p300 0 Activities
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ESR1 Tclin Estrogen receptor 0 Activities
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EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities
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DYRK1B Tchem Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0 Activities
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NR3C1 Tclin Glucocorticoid receptor 0 Activities
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DYRK1A Tchem Dual specificity tyrosine-phosphorylation-regulated kinase 1A 0 Activities
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EGFR Tclin Epidermal growth factor receptor 0 Activities
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HSD17B1 Tchem Estradiol 17-beta-dehydrogenase 1 0 Activities
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PSMB5 Tclin Proteasome subunit beta type-5 0 Activities
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SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities
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HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HDAC6 Tclin Histone deacetylase 6 0 Activities
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HDAC1 Tclin Histone deacetylase 1 0 Activities
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HDAC2 Tclin Histone deacetylase 2 0 Activities
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SNCA Tchem Alpha-synuclein 2 Activities
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TST Tchem Thiosulfate sulfurtransferase 0 Activities
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POLI Tchem DNA polymerase iota 0 Activities
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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities
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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities
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PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities
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ALOX5 Tclin Arachidonate 5-lipoxygenase 0 Activities
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GAA Tclin Lysosomal alpha-glucosidase 0 Activities
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CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities
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BACE1 Tchem Beta-secretase 1 0 Activities
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ACHE Tclin Acetylcholinesterase 0 Activities
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AR Tclin Androgen receptor 0 Activities
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ANPEP Tchem Aminopeptidase N 0 Activities
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MAOA Tclin Amine oxidase [flavin-containing] A 1 Activities
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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities
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APP Tclin Amyloid-beta A4 protein 3 Activities
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CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities
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CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities
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CLK2 Tchem Dual specificity protein kinase CLK2 0 Activities
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CLK4 Tchem Dual specificity protein kinase CLK4 0 Activities
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CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 1 Activities
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BCHE Tclin Cholinesterase 0 Activities
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HDAC8 Tclin Histone deacetylase 8 0 Activities
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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities
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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities
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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities
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PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities
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PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities
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KDM4A Tchem Lysine-specific demethylase 4A 0 Activities
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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities
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MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities
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Names and Identifiers
| IUPAC Name | (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione |
|---|---|
| INCHI | InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ |
| InChi Key | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| Canonical SMILES | COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O |
| Isomeric SMILES | COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O |
| WGK Germany | 3 |
| RTECS | MI5230000 |
| Alternate CAS | 94875-80-6 |
| PubChem CID | 969516 |
| Molecular Weight | 368.38 |
| Beilstein | 2306965 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 A2304291 | Certificate of Analysis | Oct 15, 2022 | C140600 |
| A2304614 | Certificate of Analysis | Oct 15, 2022 | C140600 |
| A2304624 | Certificate of Analysis | Oct 15, 2022 | C140600 |
| A2304625 | Certificate of Analysis | Oct 15, 2022 | C140600 |
| A2304626 | Certificate of Analysis | Oct 15, 2022 | C140600 |
| A2304632 | Certificate of Analysis | Oct 15, 2022 | C140600 |
Chemical and Physical Properties
| Solubility | Soluble in acetone, dimethylsufoxide, ethanol and dimethyl formamide. Insoluble in water. |
|---|---|
| Sensitivity | Air sensitive |
| Melt Point(°C) | 183°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | MI5230000 |