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Curcumin - from Curcuma longa (Turmeric), powder, high purity , CAS No.458-37-7

  • from Curcuma longa (Turmeric),powder
Item Number
C477437
Grouped product items
SKUSizeAvailabilityPrice Qty
C477437-5g
5g
In stock
$128.90
C477437-10g
10g
In stock
$284.90
C477437-50g
50g
In stock
$969.90
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Basic Description

Synonymscurcumin|458-37-7|Diferuloylmethane|Natural yellow 3|Indian saffron|Kacha haldi|Curcuma|Gelbwurz|Haldar|Curcumin I|Souchet|Haidr|Halad|Halud|Yellow Ginger|Terra Merita|(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione|Safran d'Inde|Yo-Ki
Specifications & Purityfrom Curcuma longa (Turmeric),powder
Biochemical and Physiological MechanismsA natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and in
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Curcumin is a yellow-colored polyphenol obtained from the rhizome ofCurcuma longaL. It constitutes an important part of various diets and herbal medicines, especially in the Asian continent for its various salubrious effects on human health.Curcumin has been used:to study its effect on the consequences and mechanism involved in the suppression of human homeobox gene NKX3.1 in the prostate cancer cell LNCaPto examine its effect on stress in pigs by having an inhibitory impact on the serum cortisol concentration, hippocampal nitric oxide production, and brain-derived neurotrophic factor expressionto study its effect as a dietary supplement on the growth, immunity, antioxidant activity, and disease resistance inOreochromis niloticusto analyze its protective effect on the organotypic hippocampal slice cultures against the synaptic toxicity caused by amyloid beta peptides (Aβ1–42)to examine the possibility of its non-toxic concentrations to decrease the inflammation caused by interleukin-1beta (IL-1β) in cartilage explant culturesto study its protective impact against intestinal ischemia-reperfusion injury in ratsto measure its antibacterial activityin vitroto determine its preventative effects for Alzheimer′s disease (AD) in miceas a bifunctional agent for generation and validation of the erythroid 2-related factor 2 (Nrf2) reporter systemto study itsin vitroinhibitory effects on human liver glucuronidation activityto evaluate its effects on Parkinson′s disease (PD)-like phenotypes

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EP300 Tchem Histone acetyltransferase p300 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DYRK1B Tchem Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DYRK1A Tchem Dual specificity tyrosine-phosphorylation-regulated kinase 1A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSD17B1 Tchem Estradiol 17-beta-dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PSMB5 Tclin Proteasome subunit beta type-5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SNCA Tchem Alpha-synuclein 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TST Tchem Thiosulfate sulfurtransferase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GAA Tclin Lysosomal alpha-glucosidase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BACE1 Tchem Beta-secretase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ANPEP Tchem Aminopeptidase N 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CLK2 Tchem Dual specificity protein kinase CLK2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CLK4 Tchem Dual specificity protein kinase CLK4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
INCHI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChi Key VFLDPWHFBUODDF-FCXRPNKRSA-N
Canonical SMILES COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
Isomeric SMILES COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
WGK Germany 3
RTECS MI5230000
Alternate CAS 94875-80-6
PubChem CID 969516
Molecular Weight 368.38
Beilstein 2306965

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
B2303978Certificate of AnalysisFeb 08, 2023 C477437
B2303979Certificate of AnalysisFeb 08, 2023 C477437
B2303980Certificate of AnalysisFeb 08, 2023 C477437

Chemical and Physical Properties

Solubility ethanol: 10mg/mL; DMSO: >11mg/mL (lit.)(lit.); 0.5 M NaOH: soluble (then immediately dilute in PBS [lit.])(lit.)
Melt Point(°C)183°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS MI5230000

Related Documents

 SDS

 Specification Sheet

References

1. Dennis D Heath,Milagros A Pruitt,Dean E Brenner,Cheryl L Rock.  (2002-11-27)  Curcumin in plasma and urine: quantitation by high-performance liquid chromatography..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  783  ((1)): (287-295).  [PMID:12450549]
2. Ho Bum Woo,Young Woo Eom,Kyu-Sang Park,Jungyeob Ham,Chan Mug Ahn,Seokjoon Lee.  (2012-01-10)  Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity..  Bioorganic & medicinal chemistry letters,  22  ((2)): (933-936).  [PMID:22222040]
3. Lin Zhang,Weiwei Zhu,Chunfen Yang,Hongxia Guo,Aihua Yu,Jianbo Ji,Yan Gao,Min Sun,Guangxi Zhai.  (2012-01-26)  A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting..  International journal of nanomedicine,  7  (151-162).  [PMID:22275831]
4. Bingshan Wu,Xueqin Yao,Xiaohu Nie,Ruxiang Xu.  (2013-04-30)  Epigenetic reactivation of RANK in glioblastoma cells by curcumin: involvement of STAT3 inhibition..  DNA and cell biology,  32  ((6)): (292-297).  [PMID:23621850]
5. Misaki Ono,Takako Higuchi,Mikako Takeshima,Chen Chen,Shuji Nakano.  (2013-05-07)  Antiproliferative and apoptosis-inducing activity of curcumin against human gallbladder adenocarcinoma cells..  Anticancer research,  33  ((5)): (1861-1866).  [PMID:23645731]
6. N Okudan,M Belviranlı,H Gökbel,M Oz,A Kumak.  (2013-05-08)  Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury..  Phytomedicine : international journal of phytotherapy and phytopharmacology,  20  ((10)): (844-848).  [PMID:23647746]
7. Masahito Takikawa,Yuta Kurimoto,Takanori Tsuda.  (2013-05-11)  Curcumin stimulates glucagon-like peptide-1 secretion in GLUTag cells via Ca2+/calmodulin-dependent kinase II activation..  Biochemical and biophysical research communications,  435  ((2)): (165-170).  [PMID:23660191]
8. Misaki Ono,Takako Higuchi,Mikako Takeshima,Chen Chen,Shuji Nakano.  (2013-06-04)  Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells..  Biochemical and biophysical research communications,  436  ((2)): (186-191).  [PMID:23726918]
9. W Tripanichkul,E-O Jaroensuppaperch.  (2013-06-07)  Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice..  European review for medical and pharmacological sciences,  17  ((10)): (1360-1368).  [PMID:23740450]
10. Takuro Kurita,Yuji Makino.  (2013-06-20)  Novel curcumin oral delivery systems..  Anticancer research,  33  ((7)): (2807-2821).  [PMID:23780965]
11. Bharat B Aggarwal,Wei Yuan,Shiyou Li,Subash C Gupta.  (2013-07-13)  Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric..  Molecular nutrition & food research,  57  ((9)): (1529-1542).  [PMID:23847105]
12. Benjawan Meesarapee,Anusorn Thampithak,Yamaratee Jaisin,Pimtip Sanvarinda,Apichart Suksamrarn,Patoomratana Tuchinda,Noppawan Phumala Morales,Yupin Sanvarinda.  (2013-07-17)  Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells..  Phytotherapy research : PTR,  28  ((4)): (611-616).  [PMID:23857913]
13. Anggakusuma,Che C Colpitts,Luis M Schang,Heni Rachmawati,Anne Frentzen,Stephanie Pfaender,Patrick Behrendt,Richard J P Brown,Dorothea Bankwitz,Joerg Steinmann,Michael Ott,Philip Meuleman,Charles M Rice,Alexander Ploss,Thomas Pietschmann,Eike Steinmann.  (2013-08-02)  Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells..  Gut,  63  ((7)): (1137-1149).  [PMID:23903236]
14. Ganji Purnachandra Nagaraju,Shijun Zhu,Jing Wen,Alton B Farris,Volkan N Adsay,Roberto Diaz,James P Snyder,Shoji Mamoru,Bassel F El-Rayes.  (2013-08-13)  Novel synthetic curcumin analogues EF31 and UBS109 are potent DNA hypomethylating agents in pancreatic cancer..  Cancer letters,  341  ((2)): (195-203).  [PMID:23933177]
15. Amalendu P Ranjan,Anindita Mukerjee,Lawrence Helson,Rohan Gupta,Jamboor K Vishwanatha.  (2013-09-12)  Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and angiogenesis..  Anticancer research,  33  ((9)): (3603-3609).  [PMID:24023285]
16. Mathew K John,Huan Xie,Edward C Bell,Dong Liang.  (2013-10-15)  Development and pharmacokinetic evaluation of a curcumin co-solvent formulation..  Anticancer research,  33  ((10)): (4285-4291).  [PMID:24122994]
17. Juliana Bender Hoppe,Marcus Haag,Benjamin Jason Whalley,Christianne Gazzana Salbego,Helena Cimarosti.  (2013-10-19)  Curcumin protects organotypic hippocampal slice cultures from Aβ1-42-induced synaptic toxicity..  Toxicology in vitro : an international journal published in association with BIBRA,  27  ((8)): (2325-2330).  [PMID:24134851]
18. Wen-Ying Lee,Yen-Chou Chen,Chwen-Ming Shih,Chun-Mao Lin,Chia-Hsiung Cheng,Ku-Chung Chen,Cheng-Wei Lin.  (2013-11-12)  The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide..  Toxicology and applied pharmacology,  274  ((1)): (55-62).  [PMID:24211270]
19. Emanuel Kronski,Micol E Fiori,Ottavia Barbieri,Simonetta Astigiano,Valentina Mirisola,Peter H Killian,Antonino Bruno,Arianna Pagani,Francesca Rovera,Ulrich Pfeffer,Christian P Sommerhoff,Douglas M Noonan,Andreas G Nerlich,Laura Fontana,Beatrice E Bachmeier.  (2014-02-04)  miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2..  Molecular oncology,  8  ((3)): (581-595).  [PMID:24484937]
20. Li Liu,Wenchao Zhang,Li Wang,Yu Li,Botao Tan,Xi Lu,Yushuang Deng,Yuping Zhang,Xiuming Guo,Jun Mu,Gang Yu.  (2014-04-30)  Curcumin prevents cerebral ischemia reperfusion injury via increase of mitochondrial biogenesis..  Neurochemical research,  39  ((7)): (1322-1331).  [PMID:24777807]
21. Priyadharshini Kumaraswamy,Swaminathan Sethuraman,Uma Maheswari Krishnan.  (2014-05-09)  Development of a dual nanocarrier system as a potential stratagem against amyloid-induced toxicity..  Expert opinion on drug delivery,  11  ((8)): (1131-1147).  [PMID:24811582]
22. Shahar Lev-Ari,Alex Starr,Sara Katzburg,Liron Berkovich,Adam Rimmon,Rami Ben-Yosef,Akiva Vexler,Ilan Ron,Gideon Earon.  (2014-05-20)  Curcumin induces apoptosis and inhibits growth of orthotopic human non-small cell lung cancer xenografts..  The Journal of nutritional biochemistry,  25  ((8)): (843-850).  [PMID:24835302]
23. Špela Zupančič,Petra Kocbek,M Gulrez Zariwala,Derek Renshaw,Mine Orlu Gul,Zeeneh Elsaid,Kevin M G Taylor,Satyanarayana Somavarapu.  (2014-05-24)  Design and development of novel mitochondrial targeted nanocarriers, DQAsomes for curcumin inhalation..  Molecular pharmaceutics,  11  ((7)): (2334-2345).  [PMID:24852198]
24. Partha Pratim Roy,Sarbani Dey Ray,Supratim Ray.  (2014-06-03)  Combined experimental and in silico approaches for exploring antiperoxidative potential of structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation using 4-HNE as the model marker..  Bioorganic chemistry,  56  (1-7).  [PMID:24887149]
25. Saurabh Gautam,Sandip Karmakar,Abhik Bose,Pramit K Chowdhury.  (2014-06-17)  β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein..  Biochemistry,  53  ((25)): (4081-4083).  [PMID:24933427]
26. Jianping Chen,Lin Li,Jianyu Su,Bing Li,Tianfeng Chen,Yum-Shing Wong.  (2014-06-28)  Synergistic apoptosis-inducing effects on A375 human melanoma cells of natural borneol and curcumin..  PloS one,  9  ((6)): (e101277-e101277).  [PMID:24971451]
27. Zun-Jing Liu,Hong-Qiang Liu,Cheng Xiao,Hui-Zhen Fan,Qing Huang,Yun-Hai Liu,Yu Wang.  (2014-07-01)  Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-γ function..  Journal of neuroscience research,  92  ((11)): (1549-1559).  [PMID:24975470]
28. Hongtao Xu,James Paxton,Joanne Lim,Yan Li,Zimei Wu.  (2014-07-08)  Development of a gradient high performance liquid chromatography assay for simultaneous analysis of hydrophilic gemcitabine and lipophilic curcumin using a central composite design and its application in liposome development..  Journal of pharmaceutical and biomedical analysis,  98  (371-378).  [PMID:24998672]
29. Prabha Arya,Ankit Srivastava,Suhas V Vasaikar,Goutam Mukherjee,Prashant Mishra,Bishwajit Kundu.  (2014-08-15)  Selective interception of gelsolin amyloidogenic stretch results in conformationally distinct aggregates with reduced toxicity..  ACS chemical neuroscience,  5  ((10)): (982-992).  [PMID:25118567]
30. Siddharth Jambhrunkar,Zhi Qu,Amirali Popat,Jie Yang,Owen Noonan,Luiz Acauan,Yusilawati Ahmad Nor,Chengzhong Yu,Surajit Karmakar.  (2014-08-29)  Effect of surface functionality of silica nanoparticles on cellular uptake and cytotoxicity..  Molecular pharmaceutics,  11  ((10)): (3642-3655).  [PMID:25166282]
31. Letícia Mazzarino,Redouane Borsali,Elenara Lemos-Senna.  (2014-09-05)  Mucoadhesive films containing chitosan-coated nanoparticles: a new strategy for buccal curcumin release..  Journal of pharmaceutical sciences,  103  ((11)): (3764-3771).  [PMID:25187001]
32. Ahmed H Matloob,Spyridon Mourtas,Pavlos Klepetsanis,Sophia G Antimisiaris.  (2014-10-01)  Increasing the stability of curcumin in serum with liposomes or hybrid drug-in-cyclodextrin-in-liposome systems: a comparative study..  International journal of pharmaceutics,  476  ((1-2)): (108-115).  [PMID:25269006]
33. Chaker Attaoua,Laure-Anaïs Vincent,Aida Abdel Jaoued,Kamel Hadj-Kaddour,Qiang Baï,John De Vos,Laurence Vian,Pierre Cuq.  (2014-10-07)  Differential involvement of glutathione S-transferase mu 1 and multidrug resistance protein 1 in melanoma acquired resistance to vinca alkaloids..  Fundamental & clinical pharmacology,  29  ((1)): (62-71).  [PMID:25283245]
34. Dewan M S Hossain,Abir K Panda,Sreeparna Chakrabarty,Pushpak Bhattacharjee,Kirti Kajal,Suchismita Mohanty,Irene Sarkar,Diptendra K Sarkar,Santosh K Kar,Gaurisankar Sa.  (2014-10-07)  MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu..  Immunology,  144  ((4)): (561-573).  [PMID:25284464]
35. S K Jain,M S Gill,H S Pawar,Sarasija Suresh.  (2014-11-27)  Novel Curcumin Diclofenac Conjugate Enhanced Curcumin Bioavailability and Efficacy in Streptococcal Cell Wall-induced Arthritis..  Indian journal of pharmaceutical sciences,  76  ((5)): (415-422).  [PMID:25425755]
36. Yangwei Wang,Yonggang Wang,Manyu Luo,Hao Wu,Lili Kong,Ying Xin,Wenpeng Cui,Yunjie Zhao,Jingying Wang,Guang Liang,Lining Miao,Lu Cai.  (2014-12-03)  Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation..  Biochimica et biophysica acta,  1852  ((1)): (34-46).  [PMID:25446993]
37. Qilu Fang,Leping Zhao,Yi Wang,Yali Zhang,Zhaoyu Li,Yong Pan,Karvannan Kanchana,Jingying Wang,Chao Tong,Dan Li,Guang Liang.  (2014-12-03)  A novel chalcone derivative attenuates the diabetes-induced renal injury via inhibition of high glucose-mediated inflammatory response and macrophage infiltration..  Toxicology and applied pharmacology,  282  ((2)): (129-138).  [PMID:25447405]
38. Li-na Sun,Zhi-xin Chen,Xiang-chun Liu,Hai-ying Liu,Guang-ju Guan,Gang Liu.  (2014-12-03)  Curcumin ameliorates epithelial-to-mesenchymal transition of podocytes in vivo and in vitro via regulating caveolin-1..  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,  68  ((8)): (1079-1088).  [PMID:25456852]
39. Surya Prakash Singh,Mrinalini Sharma,Pradeep Kumar Gupta.  (2014-12-17)  Cytotoxicity of curcumin silica nanoparticle complexes conjugated with hyaluronic acid on colon cancer cells..  International journal of biological macromolecules,  74  (162-170).  [PMID:25511568]
40. Alfeu Zanotto-Filho,Elizandra Braganhol,Karina Klafke,Fabrício Figueiró,Sílvia Resende Terra,Francis Jackson Paludo,Maurílio Morrone,Ivi Juliana Bristot,Ana Maria Battastini,Cassiano Mateus Forcelini,Alexander James Roy Bishop,Daniel Pens Gelain,José Cláudio Fonseca Moreira.  (2014-12-30)  Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas..  Cancer letters,  358  ((2)): (220-231).  [PMID:25542083]
41. Reham M Milhem,Lihadh Al-Gazali,Bassam R Ali.  (2015-01-07)  Improved plasma membrane expression of the trafficking defective P344R mutant of muscle, skeletal, receptor tyrosine kinase (MuSK) causing congenital myasthenic syndrome..  The international journal of biochemistry & cell biology,  60  (119-129).  [PMID:25562515]
42. Xu-yan Fu,Dong-wei Zhang,Ya-dong Li,Pi-wen Zhao,Yu-qing Tang,Jian-zhao Niu,Yu Li.  (2015-01-24)  Curcumin treatment suppresses CCR7 expression and the differentiation and migration of human circulating fibrocytes..  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,  35  ((2)): (489-498).  [PMID:25613752]
43. Apei Jiang,Yuan Li,Pengqi Wang,Xiaoyun Shan,Pan Jiang,Xuemin Wang,Qing Feng.  (2015-02-05)  Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells..  Journal of cellular biochemistry,  116  ((8)): (1553-1562).  [PMID:25649257]
44. Mahmoud N Taha,Michael B Krawinkel,Gertrud E Morlock.  (2015-04-08)  High-performance thin-layer chromatography linked with (bio)assays and mass spectrometry - a suited method for discovery and quantification of bioactive components? Exemplarily shown for turmeric and milk thistle extracts..  Journal of chromatography. A,  1394  (137-147).  [PMID:25846263]
45. Nirparaj Pradhan,Rajdeep Guha,Sushovan Chowdhury,Sudip Nandi,Aditya Konar,Sarbani Hazra.  (2015-04-17)  Curcumin nanoparticles inhibit corneal neovascularization..  Journal of molecular medicine (Berlin, Germany),  93  ((10)): (1095-1106).  [PMID:25877858]
46. Steven Koprowski,Kevin Sokolowski,Selvi Kunnimalaiyaan,T Clark Gamblin,Muthusamy Kunnimalaiyaan.  (2015-04-22)  Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: molecular targeting in cholangiocarcinoma..  The Journal of surgical research,  198  ((2)): (434-440).  [PMID:25890434]
47. Kun-mu Zheng,Jing Zhang,Cui-lin Zhang,Yun-wu Zhang,Xiao-chun Chen.  (2015-04-22)  Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells..  Acta pharmacologica Sinica,  36  ((5)): (544-552).  [PMID:25891083]
48. Cynthya Maria Manohar,Veluchamy Prabhawathi,Ponnurengam Malliappan Sivakumar,Mukesh Doble.  (2015-04-24)  Design of a papain immobilized antimicrobial food package with curcumin as a crosslinker..  PloS one,  10  ((4)): (e0121665-e0121665).  [PMID:25906061]
49. Dairong Feng,Ruey-Chyi Su,Liping Zou,Barbara Triggs-Raine,Shangzhi Huang,Jiuyong Xie.  (2015-05-03)  Increase of a group of PTC(+) transcripts by curcumin through inhibition of the NMD pathway..  Biochimica et biophysica acta,  1849  ((8)): (1104-1115).  [PMID:25934542]
50. Mehmet Oz,K Esra Nurullahoglu Atalik,F Humeyra Yerlikaya,Enver Ahmet Demir.  (2015-05-20)  Curcumin alleviates cisplatin-induced learning and memory impairments..  Neurobiology of learning and memory,  123  (43-49).  [PMID:25982942]
51. Nikhil Baban Ghate,Dipankar Chaudhuri,Abhishek Das,Sourav Panja,Nripendranath Mandal.  (2015-05-27)  An Antioxidant Extract of the Insectivorous Plant Drosera burmannii Vahl. Alleviates Iron-Induced Oxidative Stress and Hepatic Injury in Mice..  PloS one,  10  ((5)): (e0128221-e0128221).  [PMID:26010614]
52. Alan Yueh-Luen Lee,Chi-Chen Fan,Yen-An Chen,Chieh-Wen Cheng,Ya-Ju Sung,Chih-Ping Hsu,Ting-Yu Kao.  (2015-06-04)  Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway..  Integrative cancer therapies,  14  ((5)): (484-490).  [PMID:26036622]
53. Jianping Chen,Lin Li,Jianyu Su,Bing Li,Xia Zhang,Tianfeng Chen.  (2015-06-09)  Proteomic Analysis of G2/M Arrest Triggered by Natural Borneol/Curcumin in HepG2 Cells, the Importance of the Reactive Oxygen Species-p53 Pathway..  Journal of agricultural and food chemistry,  63  ((28)): (6440-6449).  [PMID:26051007]
54. Samina Akhter,Md Atiar Rahman,Jannatul Aklima,Md Rakibul Hasan,J M Kamirul Hasan Chowdhury.  (2015-07-30)  Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats..  BioMed research international,  2015  (356729-356729).  [PMID:26221590]
55. Paria Motahari,Majid Sadeghizadeh,Mehrdad Behmanesh,Shaghayegh Sabri,Fatemeh Zolghadr.  (2015-08-02)  Generation of stable ARE- driven reporter system for monitoring oxidative stress..  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences,  23  (38-38).  [PMID:26231224]
56. Katiúscia Vieira Jardim,Graziella Anselmo Joanitti,Ricardo Bentes Azevedo,Alexandre Luis Parize.  (2015-08-08)  Physico-chemical characterization and cytotoxicity evaluation of curcumin loaded in chitosan/chondroitin sulfate nanoparticles..  Materials science & engineering. C, Materials for biological applications,  56  (294-304).  [PMID:26249593]
57. Krupa Shah,Sheefa Mirza,Urja Desai,Nayan Jain,Rakesh Rawal.  (2015-08-19)  Synergism of Curcumin and Cytarabine in the Down Regulation of Multi-Drug Resistance Genes in Acute Myeloid Leukemia..  Anti-cancer agents in medicinal chemistry,  16  ((1)): (128-135).  [PMID:26278546]
58. Lichuan Wu,Liangxia Guo,Yuehui Liang,Xu Liu,Lihe Jiang,Lisheng Wang.  (2015-09-24)  Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway..  Oncology reports,  34  ((6)): (3311-3317).  [PMID:26397387]
59. Paola Maria Bonaccorsi,Manuela Labbozzetta,Anna Barattucci,Tania Maria Grazia Salerno,Paola Poma,Monica Notarbartolo.  (2019-11-14)  Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines..  Pharmaceuticals (Basel, Switzerland),  12  ((4)):   [PMID:31717764]
60. Lujing Wang,Wenji Li,David Cheng,Yue Guo,Renyi Wu,Ran Yin,Shanyi Li,Hsiao-Chen Kuo,Rasika Hudlikar,Hilly Yang,Brian Buckley,Ah-Ng Kong.  (2020-02-06)  Pharmacokinetics and pharmacodynamics of three oral formulations of curcumin in rats..  Journal of pharmacokinetics and pharmacodynamics,  47  ((2)): (131-144).  [PMID:32020381]
61. Paula Aranaz,David Navarro-Herrera,María Zabala,Ana Romo-Hualde,Miguel López-Yoldi,José Luis Vizmanos,Fermín I Milagro,Carlos J González-Navarro.  (2020-11-05)  Phenolic Compounds Reduce the Fat Content in Caenorhabditis elegans by Affecting Lipogenesis, Lipolysis, and Different Stress Responses..  Pharmaceuticals (Basel, Switzerland),  13  ((11)):   [PMID:33143060]
62. Yinfeng Xu,Yaosen Wu,Lei Wang,Chuying Qian,Qian Wang,Wei Wan.  (2020-11-11)  Identification of curcumin as a novel natural inhibitor of rDNA transcription..  Cell cycle (Georgetown, Tex.),  19  ((23)): (3362-3374).  [PMID:33171062]
63. Misha Mao,Dengdi Hu,Jingjing Yang,Yongxia Chen,Xun Zhang,Jianguo Shen,Rongyue Teng,Jichun Zhou,Linbo Wang.  (2021-02-22)  Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change..  Journal of molecular medicine (Berlin, Germany),  99  ((6)): (845-858).  [PMID:33611659]
64. Vivian Soetikno,Kenji Suzuki,Punniyakoti T Veeraveedu,Somasundaram Arumugam,Arun P Lakshmanan,Hirohito Sone,Kenichi Watanabe.  (2013-05-09)  Molecular understanding of curcumin in diabetic nephropathy..  Drug discovery today,  18  ((15-16)): (756-763).  [PMID:23651956]
65. Rashmi Sareen,Nitin Jain,Vinay Pandit.  (2013-06-19)  Curcumin: a boon to colonic diseases..  Current drug targets,  14  ((10)): (1210-1218).  [PMID:23768171]
66. Hannelore Rücker,Nafisah Al-Rifai,Anne Rascle,Eva Gottfried,Lidia Brodziak-Jarosz,Clarissa Gerhäuser,Tobias P Dick,Sabine Amslinger.  (2015-01-27)  Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site..  Organic & biomolecular chemistry,  13  ((10)): (3040-3047).  [PMID:25622264]
67. Qinghua Yao,Miao Lin,Yuqi Wang,Yuebiao Lai,Jingjing Hu,Ting Fu,Lu Wang,Shuyuan Lin,Liangliang Chen,Yong Guo.  (2015-08-28)  Curcumin induces the apoptosis of A549\xa0cells via oxidative stress and MAPK signaling pathways..  International journal of molecular medicine,  36  ((4)): (1118-1126).  [PMID:26310655]
68. Lijuan Wei,Zhaoyong Wang,Yang Xia,Baichun Liu.  (2019-07-14)  The mechanism and tumor inhibitory study of Lagopsis supine ethanol extract on colorectal cancer in nude mice..  BMC complementary and alternative medicine,  19  ((1)): (173-173).  [PMID:31299960]
69. Angus Lau,Raphaella W L So,Heather H C Lau,Jason C Sang,Alejandro Ruiz-Riquelme,Shelaine C Fleck,Erica Stuart,Sindhu Menon,Naomi P Visanji,Georg Meisl,Rania Faidi,Maria M Marano,Cian Schmitt-Ulms,Zhilan Wang,Paul E Fraser,Anurag Tandon,Bradley T Hyman,Holger Wille,Martin Ingelsson,David Klenerman,Joel C Watts.  (2019-12-04)  α-Synuclein strains target distinct brain regions and cell types..  Nature neuroscience,  23  ((1)): (21-31).  [PMID:31792467]
70. Abigail R Esquivel,Jenna C Douglas,Rachel M Loughran,Thomas E Rezendes,Kaela R Reed,Tobias H L Cains,Sarah A Emsley,William A Paddock,Patrick Videau,Marc J Koyack,Brie E Paddock.  (2020-10-11)  Assessing the influence of curcumin in sex-specific oxidative stress, survival and behavior in Drosophila melanogaster..  The Journal of experimental biology,  223  ((Pt 22)):   [PMID:33037110]
71. Yoshikane Yamauchi,Yotaro Izumi,Jun Yamamoto,Hiroaki Nomori.  (2013-08-15)  Coadministration of erlotinib and curcumin augmentatively reduces cell viability in lung cancer cells..  Phytotherapy research : PTR,  28  ((5)): (728-735).  [PMID:23943298]

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