CYC116 - 98%, high purity , Vascular endothelial growth factor receptor 2 inhibitor, CAS No.693228-63-6, Vascular endothelial growth factor receptor 2 inhibitor

Item Number

C126929

• Synonyms: 693228-63-6 | CYC-116 | CYC116 | 4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine | CYC 116 | CHEMBL482967 | Kinome_636 | 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine | YAX4981K2D | 4-methyl-5-(2-((4-morpholinophenyl)amino
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms:

  CYC-116 is an orally bioavailable，small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC-116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibit

• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: Vascular endothelial growth factor receptor 2 inhibitor

Product Description

 Product Description：

CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.