Cyclin D3/CCND3 Antibody - Primary antibody, specific to CCND3, Rabbit IgG

    Application:
  • WB
Features and benefits
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human,Mouse
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab098455
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab098455-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab098455-50μl
50μl
In stock
$189.90
Ab098455-100μl
100μl
In stock
$239.90
Ab098455-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,999.90

pAb; Rabbit anti Human Cyclin D3/CCND3 Antibody; WB; Unconjugated

Basic Description

Product NameCyclin D3/CCND3 Antibody - Primary antibody, specific to CCND3, Rabbit IgG
SynonymsCCND3 | Cyclin D3 | D3-type cyclin | G1/S-specific cyclin D3 | G1/S-specific cyclin-D3 | CCND 3 antibody | Ccnd3 antibody | CCND3_HUMAN antibody | CyclinD3 antibody | D3 type cyclin antibody | G1 S specific cyclin D3 antibody | G1/S specific cyclin D3 ant
Specifications & PurityExactAb™, Validated, Carrier Free, High performance, Lot by Lot
Host speciesRabbit
SpecificityCCND3
ImmunogenRecombinant CCND3 expressed in E.coli (AA 1-292)
Positive ControlWB: A549, K562, RAW 264.7 and NIH/3T3 cell lysates.
ConjugationUnconjugated
GradeCarrier Free, ExactAb™, High Performance, Validated
Note20μl卖完停产,不再备货
Product Description

Rabbit anti Human Cyclin D3/CCND3 Antibody, Polyclonal, could be used for WB and so on.
Application:
WB: : 0.01-3µg/mL
Protein Function
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Cyclin D3/CCND3 Antibody (Ab098455) - Western Blot
All lanes: Cyclin D3/CCND3 Antibody (Ab098455) at 1/2000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 31 kDa
Observed band size: 32 kDa
Exposure time: 32.2 s

Associated Targets(Human)

CCND3 Tchem G1/S-specific cyclin-D3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CCND3 Tchem G1/S-specific cyclin D3 (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCND3 Tchem CDK6/cyclin D3 (897 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Application

ApplicationDilution info
WB

0.01-3 µg/mL

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F1101693Certificate of AnalysisNov 16, 2023 Ab098455
ZJ23F1101692Certificate of AnalysisNov 16, 2023 Ab098455

Related Documents

References

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