Cyclopamine - ≥99%, high purity , CAS No.4449-51-8, Antagonist of SMO

Item Number

C125994

• Synonyms: CYCLOPAMINE | 11-Deoxojervine | 4449-51-8 | 11-Deoxyjervine | Jervine, 11-deoxo- | CHEBI:4021 | CHEMBL254129 | DTXSID6043709 | ZH658AJ192 | NSC-734950 | Cyclopamine Tartrate | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octad
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Cyclopamine is a teratogenic Smo inhibitor famous for inducing cyclopia in developing mammalian fetuses. Cyclopia arises from improper differentiation in the fetus, a process heavily regulated by the Hedgehog (Hh) signaling pathway. The proteins Smo and p
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of SMO
• Note: This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.
A hedgehog [Hh] signaling pathway and Smo inhibitor.