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Cyclopamine - ≥99%, high purity , CAS No.4449-51-8, Antagonist of SMO

Specifications & Purity:  ≥99%
Item Number
C125994
Grouped product items
SKUSizeAvailabilityPrice Qty
C125994-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$58.90
C125994-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$88.90
C125994-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$266.90
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Hh signaling inhibitor

View related series
SMO Antagonist

Basic Description

SynonymsCYCLOPAMINE|11-Deoxojervine|4449-51-8|11-Deoxyjervine|Jervine, 11-deoxo-|CHEBI:4021|CHEMBL254129|DTXSID6043709|ZH658AJ192|NSC-734950|Cyclopamine Tartrate|(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octad
Specifications & Purity≥99%
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeANTAGONIST
Mechanism of actionAntagonist of SMO

Associated Targets

SMO Tclin Smoothened homolog 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SHH Tchem Sonic hedgehog protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
INCHI InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
InChi Key QASFUMOKHFSJGL-LAFRSMQTSA-N
Canonical SMILES CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
Isomeric SMILES C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1
Alternate CAS 4449-51-8
PubChem CID 442972
NSC Number 734950
MeSH Entry Terms cyclopamine
Molecular Weight 411.62

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
E1803071Certificate of AnalysisOct 16, 2023 C125994
E1528101Certificate of AnalysisDec 08, 2022 C125994
E1803072Certificate of AnalysisJan 21, 2022 C125994

Chemical and Physical Properties

SolubilitySoluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements H341,H361
Precautionary Statements P280,P405,P501,P281,P203,P318

Related Documents

 SDS

 Specification Sheet

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References

1. Turner MW, Cruz R, Mattos J, Baughman N, Elwell J, Fothergill J, Nielsen A, Brookhouse J, Bartlett A, Malek P et al..  (2016)  Cyclopamine bioactivity by extraction method from Veratrum californicum..  Bioorg Med Chem,  24  (16): (3752-7).  [PMID:27338657]
2. Ding S et al..  (2017)  Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy..  Aging Dis,  8  (4): (442-457).  [PMID:28840059]
3. Dong H et al..  (2019)  GLI1 activation by non-classical pathway integrin avß3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis..  Cell Death Dis,  10  (8): (574).  [PMID:31366904]
4. Qi H et al..  (2019)  Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis..  J Bone Miner Res,  34  (3): (533-546).  [PMID:30352124]

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