| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C276580-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $58.90 |
Hh signaling inhibitor
| Synonyms | (3beta,22S,23R)-17,23-epoxyveratraman-3-ol | A881419 | HMS3403D13 | GAMMA CYCLODEXTRIN [MART.] | BRD-K58938839-001-03-8 | CCG-208181 | CS-0633 | Cyclopamine Tartrate | Jervine, 11-deoxo- | (E)-4,4'-(1,2-Ethenediyl)bisbenzenamine | 11-Deoxyjervine | CYCLOP |
|---|---|
| Specifications & Purity | Moligand™, ≥99% |
| Biochemical and Physiological Mechanisms | Cell-permeable inhibitor of hedgehog (Hh) signaling, via direct inhibition of Smo (Smoothened), the accessory protein to the putative Hh receptor. Anticancer and teratogenic activity in vivo . Also available as a solid . |
| Storage Temp | Protected from light,Store at -20°C,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. |
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| IUPAC Name | (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol |
|---|---|
| INCHI | InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1 |
| InChi Key | QASFUMOKHFSJGL-LAFRSMQTSA-N |
| Canonical SMILES | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 |
| Isomeric SMILES | C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1 |
| Alternate CAS | 4449-51-8 |
| PubChem CID | 442972 |
| NSC Number | 734950 |
| MeSH Entry Terms | cyclopamine |
| Molecular Weight | 411.62 |
Enter Lot Number to search for COA:
| Solubility | Supplied in ethanol (10 mM) |
|---|---|
| Sensitivity | air and light sensitive |
| Pictogram(s) | GHS08 |
|---|---|
| Signal | Warning |
| Hazard Statements | H341:Suspected of causing genetic defects H361:Suspected of damaging fertility or the unborn child |
| Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P281:Use personal protective equipment as required. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
| 1. Ju Li, Jinmei Zuo, Xiaoyan Lv, Jiahe Ma, Xiaohong Li, Simiao Fu, Jinsheng Sun. (2023) Hedgehog signaling is essential in the regulation of limb regeneration in the Chinese mitten crab, Eriocheir sinensis. FISH & SHELLFISH IMMUNOLOGY, 140 (108981). [PMID:37543149] [10.1016/j.fsi.2023.108981] |
| 2. Zhao Ye, Wang Huiling, He Tianhua, Ma Bo, Chen Guoguang, Tzeng Chimeng. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of Cell Communication and Signaling, (1-20). [PMID:37338798] [10.1007/s12079-023-00775-6] |
| 3. Tingting Lv, Lei Shen, Lei Yang, Wenxiu Diao, Zhenming Yang, Ying Zhang, Shijie Yu, Yanxia Li. (2018) Polydatin ameliorates dextran sulfate sodium-induced colitis by decreasing oxidative stress and apoptosis partially via Sonic hedgehog signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 64 (256). [PMID:30218952] [10.1016/j.intimp.2018.09.009] |
| 4. Kuiyuan Song, Guanqun Zheng, Yue Zhao. (2018) Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway. CELL BIOLOGY INTERNATIONAL, 42 (8): (994-1005). [PMID:29573522] [10.1002/cbin.10965] |
| 5. Sha Feng, Jue Liu, Biao Cheng, Aiping Deng, Hong Zhang. (2018) (-)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway. Experimental and Therapeutic Medicine, 15 (5): (4284-4290). [PMID:29731823] [10.3892/etm.2018.5936] |
| 1. Ju Li, Jinmei Zuo, Xiaoyan Lv, Jiahe Ma, Xiaohong Li, Simiao Fu, Jinsheng Sun. (2023) Hedgehog signaling is essential in the regulation of limb regeneration in the Chinese mitten crab, Eriocheir sinensis. FISH & SHELLFISH IMMUNOLOGY, 140 (108981). [PMID:37543149] [10.1016/j.fsi.2023.108981] |
| 2. Zhao Ye, Wang Huiling, He Tianhua, Ma Bo, Chen Guoguang, Tzeng Chimeng. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of Cell Communication and Signaling, (1-20). [PMID:37338798] [10.1007/s12079-023-00775-6] |
| 3. Tingting Lv, Lei Shen, Lei Yang, Wenxiu Diao, Zhenming Yang, Ying Zhang, Shijie Yu, Yanxia Li. (2018) Polydatin ameliorates dextran sulfate sodium-induced colitis by decreasing oxidative stress and apoptosis partially via Sonic hedgehog signaling pathway. INTERNATIONAL IMMUNOPHARMACOLOGY, 64 (256). [PMID:30218952] [10.1016/j.intimp.2018.09.009] |
| 4. Kuiyuan Song, Guanqun Zheng, Yue Zhao. (2018) Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway. CELL BIOLOGY INTERNATIONAL, 42 (8): (994-1005). [PMID:29573522] [10.1002/cbin.10965] |
| 5. Sha Feng, Jue Liu, Biao Cheng, Aiping Deng, Hong Zhang. (2018) (-)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway. Experimental and Therapeutic Medicine, 15 (5): (4284-4290). [PMID:29731823] [10.3892/etm.2018.5936] |
