| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab098512-10μl | 10μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $66.90 | |
| Ab098512-20μl | 20μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $734.90 | |
| Ab098512-50μl | 50μl | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $199.90 | |
| Ab098512-100μl | 100μl | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $299.90 | |
| Ab098512-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,169.90 |
mAb(C1); Mouse anti Human Cyclophilin B Antibody; WB, IHC; Unconjugated
| Product Name | Cyclophilin B Mouse mAb - Primary antibody, specific to PPIB, Mouse IgG1 |
|---|---|
| Synonyms | AA408962 antibody | AA553318 antibody | AI844835 antibody | Cphn 2 antibody | Cphn2 antibody | Cyclophilin B antibody | Cyclophilin like protein antibody | CyP 20b antibody | CYP S1 antibody | CYP-S1 antibody | CYPB antibody | EC 5.2.1.8 antibody | MGC141 |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Azide Free, High performance, Lot by Lot |
| Host species | Mouse |
| Specificity | PPIB |
| Immunogen | Recombinant CYPB expressed in E.coli (AA 47-216) |
| Positive Control | WB: HeLa, Jurkat,HT-29, A431, THP-1, Hep G2, C6 and NIH/3T3 cell lysates. IHC: Human placenta tissue. |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, High Performance, Validated |
| Product Description | Mouse anti Human Cyclophilin B Antibody, Monoclonal (C1),could be used for WB, IHC and so on. |
| Isotype | Mouse IgG1 |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A + Protein G affinity chromatography |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term. Store at -20°C long term (12 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Cyclophilin B Mouse mAb (Ab098512) - Western Blot
All lanes: Cyclophilin B Mouse mAb (Ab098512) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution
Predicted band size: 24 kDa
Observed band size: 21 kDa
Exposure time: 10.0 s
Cyclophilin B Mouse mAb (Ab098512) - IHC
DAB staining on IHC
Samples: Human Liver Tissue
Primary Ab: 10 μg/mL Cyclophilin B Mouse mAb (Ab098512)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.
Cyclophilin B Mouse mAb (Ab098512) - IHC
DAB staining on IHC
Samples: Human Kidney Tissue
Primary Ab: 10 μg/mL Cyclophilin B Mouse mAb (Ab098512)
Second Ab: 2 µg/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Application | Dilution info |
|---|---|
| WB |
0.2-2 µg/mL
|
| IHC | 2-20 µg/mL |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F0901110 | Certificate of Analysis | Jun 25, 2024 | Ab098512 |
| ZJ23F0901111 | Certificate of Analysis | Jun 25, 2024 | Ab098512 |
| 1. Malesevic M, Gutknecht D, Prell E, Klein C, Schumann M, Nowak RA, Simon JC, Schiene-Fischer C, Saalbach A.. (2013) Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147.. J Med Chem, 56 (18): (7302-7311). [PMID:23964991] |
| 2. Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, Kasprzyk T, Knapp M, Leung K, Li X, Lu P, Mergo W, Miault C, Ng S, Parker D, Peng Y, Roggo S, Rivkin A, Simmons RL, Wang M, Wiedmann B, Weiss AH, Xiao L, Xie L, Xu W, Yifru A, Yang S, Zhou B, Sweeney ZK.. (2014) Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.. J Med Chem, 57 (20): (8503-8516). [PMID:25310383] |
| 3. Yang S, K R J, Lim S, Choi TG, Kim JH, Akter S, Jang M, Ahn HJ, Kim HY, Windisch MP, Khadka DB, Zhao C, Jin Y, Kang I, Ha J, Oh BC, Kim M, Kim SS, Cho WJ.. (2015) Structure-Based Discovery of Novel Cyclophilin A Inhibitors for the Treatment of Hepatitis C Virus Infections.. J Med Chem, 58 (24): (9546-9561). [PMID:26613291] |
| 4. Rasmussen, H H HH and 5 more authors.. (1992) Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.. Electrophoresis, [PMID:1286667] |
| 5. Arber, S S, Krause, K H KH and Caroni, P P.. (1992) s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin.. The Journal of cell biology, [PMID:1530944] |
| 6. Hasel, K W KW, Glass, J R JR, Godbout, M M and Sutcliffe, J G JG.. (1991) An endoplasmic reticulum-specific cyclophilin.. Molecular and cellular biology, [PMID:1710767] |
| 7. Price, E R ER and 5 more authors.. (1991) Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:2000394] |
| 8. Spik, G G and 9 more authors.. (1991) A novel secreted cyclophilin-like protein (SCYLP).. The Journal of biological chemistry, (15): [PMID:2040592] |
| 9. Mikol, V V, Kallen, J J and Walkinshaw, M D MD.. (1994) X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.. Proceedings of the National Academy of Sciences of the United States of America, (24): [PMID:8197205] |
| 10. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352] |
| 11. Meunier, Laurent L, Usherwood, Young-Kwang YK, Chung, Kyung Tae KT and Hendershot, Linda M LM.. (2002) A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.. Molecular biology of the cell, [PMID:12475965] |
| 12. Zody, Michael C MC and 68 more authors.. (2006) Analysis of the DNA sequence and duplication history of human chromosome 15.. Nature, (30): [PMID:16572171] |
| 13. Chi, An A and 16 more authors.. (2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.. Journal of proteome research, [PMID:17081065] |
| 14. Daum, Sebastian and 9 more authors.. (2009) Isoform-specific inhibition of cyclophilins.. Biochemistry, (7): [PMID:19480458] |
| 15. van Dijk, Fleur S FS and 20 more authors.. (2009) PPIB mutations cause severe osteogenesis imperfecta.. American journal of human genetics, [PMID:19781681] |
| 16. Barnes, Aileen M AM and 10 more authors.. (2010) Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding.. The New England journal of medicine, (11): [PMID:20089953] |
| 17. Watanabe, Akira A and 5 more authors.. (2010) CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.. Journal of virology, [PMID:20147391] |
| 18. Davis, Tara L TL and 11 more authors.. (2010) Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.. PLoS biology, (27): [PMID:20676357] |
| 19. Kozlov, Guennadi G and 8 more authors.. (2010) Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.. The Journal of biological chemistry, (12): [PMID:20801878] |
| 20. Denais, Celine C and 6 more authors.. (2011) Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and golgi organization and is associated with protein secretion pathways critical in bone development.. Human mutation, [PMID:21280149] |
| 21. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460] |
