Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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C126044-25mg | 25mg | In stock | $17.90 | |
C126044-100mg | 100mg | In stock | $58.90 | |
C126044-500mg | 500mg | In stock | $165.90 |
Alkylating agent; chemotherapeutic
Specifications & Purity | Moligand™, ≥98% |
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Biochemical and Physiological Mechanisms | Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.Alkylating agent; pro-drug capable of inducing DNA single-strand breaks . Efficacious in vitro and in vivo . |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Cyclophosphamide has been reported to be an anti-proliferative agent that regulates Bax and Bcl-2 expression. This compound also inhibits aldehyde dehydrogenase 1 through its degradation product acrolein. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine |
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INCHI | InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12) |
InChi Key | CMSMOCZEIVJLDB-UHFFFAOYSA-N |
Canonical SMILES | C1CNP(=O)(OC1)N(CCCl)CCCl |
Isomeric SMILES | C1CNP(=O)(OC1)N(CCCl)CCCl |
PubChem CID | 2907 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 261.09 |
DrugBank Ligand | DB00531 |
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PubChem CID | 2907 |
CAS Registry No. | 50-18-0 |
ChEMBL Ligand | CHEMBL88 |
Wikipedia | Cyclophosphamide |
PEP | cyclophosphamide |
Immunopaedia Search | cyclophosphamide |
DrugCentral Ligand | 758 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2425239 | Certificate of Analysis | Sep 30, 2024 | C126044 |
I2425238 | Certificate of Analysis | Sep 30, 2024 | C126044 |
I2425236 | Certificate of Analysis | Sep 30, 2024 | C126044 |
G2418537 | Certificate of Analysis | Jul 25, 2024 | C126044 |
D2418559 | Certificate of Analysis | May 07, 2024 | C126044 |
D2418560 | Certificate of Analysis | May 07, 2024 | C126044 |
D2410258 | Certificate of Analysis | Mar 09, 2024 | C126044 |
A2431064 | Certificate of Analysis | Feb 06, 2024 | C126044 |
A2431073 | Certificate of Analysis | Feb 06, 2024 | C126044 |
A2431074 | Certificate of Analysis | Feb 06, 2024 | C126044 |
A2431062 | Certificate of Analysis | Feb 06, 2024 | C126044 |
K2314568 | Certificate of Analysis | Nov 21, 2023 | C126044 |
K2314554 | Certificate of Analysis | Nov 21, 2023 | C126044 |
F2327323 | Certificate of Analysis | Jul 05, 2023 | C126044 |
F2327324 | Certificate of Analysis | Jul 05, 2023 | C126044 |
F2327330 | Certificate of Analysis | Jul 05, 2023 | C126044 |
F2327322 | Certificate of Analysis | Jul 05, 2023 | C126044 |
F2327312 | Certificate of Analysis | Jul 05, 2023 | C126044 |
F2327310 | Certificate of Analysis | Jul 05, 2023 | C126044 |
C2315246 | Certificate of Analysis | Mar 16, 2023 | C126044 |
C2314366 | Certificate of Analysis | Mar 16, 2023 | C126044 |
C2314354 | Certificate of Analysis | Mar 16, 2023 | C126044 |
Solubility | 25°C: DMSO 52mg/mL; Water 43 mg/mL; Ethanol 52 mg/mL |
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Melt Point(°C) | 49.2-52.8°C |
Pictogram(s) | GHS06, GHS08, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H302:Harmful if swallowed H318:Causes serious eye damage H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H340:May cause genetic defects H350:May cause cancer |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P319:Get medical help if you feel unwell. |
Class | 6.1 |
1. Leilei Gong, Jinli Hou, Hongjun Yang, Xueyan Zhang, Jingxia Zhao, Lan Wang, Xiaojie Yin, Xin Feng, Chenghong Yin. (2024) Kuntai capsule attenuates premature ovarian insufficiency by activating the FOXO3/SIRT5 signaling pathway in mice: A comprehensive study using UHPLC-LTQ-Orbitrap and integrated pharmacology. JOURNAL OF ETHNOPHARMACOLOGY, 322 (117625). [PMID:38145859] |
2. Shuna Chen, Jiaxin Kang, Huanqing Zhu, Ziyi Han, Leyu Wang, Kaixi Wang, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li. (2024) Tea seed saponins ameliorate cyclophosphamide-induced intestinal injury, immune disorder and gut microbial dysbiosis in mice. Food Bioscience, 57 (103504). [PMID:] |
3. Jimin Ni, Junping Zheng, Guoyan Mo, Guangming Chen, Jingjing Li, Lu Cao, Baifei Hu, Hongtao Liu. (2024) Structural characterization and immunomodulatory effect of a starch-like Grifola frondosa polysaccharides on cyclophosphamide-induced immunosuppression in mice. CARBOHYDRATE RESEARCH, 535 (109011). [PMID:38150753] |
4. Meng Wang, Qiwen Wang, Xiaohong Wang, Shengtian Wang. (2024) Nitrogen doped biomass derived carbon and BiVO4 composite for simultaneous detection of furazolidone and chloramphenicol. MICROCHEMICAL JOURNAL, 197 (109810). [PMID:] |
5. Yan Zhang, Qirui Xu, Yazi Wang, Chenchen Zhang, Shan Xu, Manhong Luo, Shuhan Yang. (2023) Caragana sinica (Buc'hoz) Rehd. (jin ji er) polysaccharide regulates the immune function and intestinal microbiota of cyclophosphamide (CTX) induced immunosuppressed mice. JOURNAL OF ETHNOPHARMACOLOGY, (117551). [PMID:38081398] |
6. Qian Han, Ling Fan, Xiuying Liu, Yiwei Tang, Pingping Wang, Zaixi Shu, Wei Zhang, Lijie Zhu. (2023) Lateral Flow Immunoassay Based on Quantum-Dot Nanobeads for Detection of Chloramphenicol in Aquatic Products. MOLECULES, 28 (22): (7496). [PMID:38005218] |
7. Mu Yi, Che Bangwei, Tang Kaifa, Zhang Wenjun, Xu Shenghan, Li Wei, He Jun, Liu Miao, Chen Peng, Zhong Siwen, Li Guangyu. (2023) Dendrobium officinale polysaccharides improved reproductive oxidative stress injury in male mice treated with cyclophosphamide. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, (1): (1-11). [PMID:37728673] |
8. Fang Li, Shuyue Xiong, Pei Zhao, Panpan Dong, Zijian Wu. (2023) Few Layer Ti3C2 MXene-Based Label-Free Aptasensor for Ultrasensitive Determination of Chloramphenicol in Milk. MOLECULES, 28 (16): (6074). [PMID:37630325] |
9. Chen Yan, Huiru Qu, Xinli Li, Bin Feng. (2023) Holothurian Wall Hydrolysate Ameliorates Cyclophosphamide-Induced Immunocompromised Mice via Regulating Immune Response and Improving Gut Microbiota. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (16): (12583). [PMID:37628768] |
10. Jutao Hu, Xiaoyu Su, Lei Yuan, Kaiyi Zheng, Xiaobo Zou, Zongbao Sun, Xuechao Xu, Wen Zhang. (2023) Competitive immunoassay using enzyme-regulated Fe3O4@COF/Fe3+ fluorescence probe for natural chloramphenicol detection. ANALYTICA CHIMICA ACTA, 1277 (341680). [PMID:37604605] |
11. Yao Liu, Zhichao He, Heng Liang, Minzhen Han, Jinxingyi Wang, Qian Liu, Yanping Guan. (2023) A high-throughput UHPLC-MS/MS method for the determination of eight anti-tumor drugs in plasma. ANALYTICAL BIOCHEMISTRY, 676 (115230). [PMID:37429484] |
12. Jingyu Ren, Xinyi Yang, Zhouzhou Yao, Qian Wei, He Guo, Zhirui Niu, Jian Wang, Jin Han, Jijiang Wang, Yanzhong Zhen. (2023) F-enhanced anti-bonding activation effect of FeO on catalytic degradation of chloramphenicol by dielectric barrier discharge plasma. SEPARATION AND PURIFICATION TECHNOLOGY, 323 (124402). [PMID:] |
13. Yanan Li, Junping Zheng, Yao Wang, Huabing Yang, Lu Cao, Shuiyong Gan, Jun Ma, Hongtao Liu. (2023) Immuno-stimulatory activity of Astragalus polysaccharides in cyclophosphamide-induced immunosuppressed mice by regulating gut microbiota. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 242 (124789). [PMID:37164141] |
14. Anqi Xie, Hao Wan, Lei Feng, Boyun Yang, Yiqun Wan. (2023) Protective Effect of Anoectochilus formosanus Polysaccharide against Cyclophosphamide-Induced Immunosuppression in BALB/c Mice. Foods, 12 (9): (1910). [PMID:37174447] |
15. Jiachen Zhuang, Qianqian Wang, Fei Shen, Jing Wang, Juan Du, Peng Yu, Fengqin Feng, Minjie Zhao. (2023) The mediation of the AHR/IL-22/STAT3/IL-6 axis by soft-shelled turtle (Pelodiscus sinensis) peptide and Chinese pond turtle (Chinemys reevesii) peptide contributed to their amelioration effects on intestinal mucosal immunity in immunosuppressed mice. Food & Function, [PMID:37102758] |
16. Chaoyang Zhang, Conghao Gao, Shumin Yang, Xin He, Yue Chen, Xiao Qin, Yulin Tang. (2023) Electrochemical oxidation of chloramphenicol by modified Sm-PEG-PbO2 anodes: Performance and mechanism. CHEMOSPHERE, 327 (138518). [PMID:37001761] |
17. Gu Shi, Chong Yan, Junhua Chen. (2023) Fluorescent aptasensor for the ultrasensitive detection of antibiotic residue in food samples based on dumbbell DNA-mediated signal amplification. BIOSENSORS & BIOELECTRONICS, 228 (115188). [PMID:36871423] |
18. Siyu Wang, Lutong Wang, Jingwen Xu, Yihai Wang, Limin Xiang, Xiangjiu He. (2023) Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (7): (3315–3324). [PMID:36752041] |
19. Qi Jiaxu, Liu Xingyu, Zhang Yupeng, Zhu Guanya, Tang Shanshan, Yu Xiaoxiao, Su Yingjie, Chen Siji, Liang Dadong, Chen Guang. (2023) Adsorption of chloramphenicol from water using Carex meyeriana Kunth-derived hierarchical porous carbon with open channel arrays. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (11): (31060-31076). [PMID:36441301] |
20. Ren Zhexin, Yang Fei, Yao Sijia, Bi Lijun, Jiang Guanqin, Huang Ju, Tang Yunping. (2022) Effects of low molecular weight peptides from monkfish (Lophius litulon) roe on immune response in immunosuppressed mice. Frontiers in Nutrition, 9 [PMID:36211506] |
21. Hao Feng, Junhua Li, Yuqing Liu, Zhifeng Xu, Ying Cui, Mengqin Liu, Xing Liu, Lingzhi He, Jianbo Jiang, Dong Qian. (2022) Cubic MnSe2 nanoparticles dispersed on multi-walled carbon nanotubes: A robust electrochemical sensing platform for chloramphenicol. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 922 (116755). [PMID:] |
22. Shiqi Duan, Yan Jia, Zhihang Zhu, Lancheng Wang, Peng Xu, Youmei Wang, Bin Di, Chi Hu. (2022) Induction of CYP450 by illicit drugs: Studies using an in vitro 3D spheroidal model in comparison to animals. TOXICOLOGY LETTERS, 367 (88). [PMID:35914676] |
23. Jiang Yingying, Tao Yali, Chen Yutong, Xue Xu, Ding Gangyi, Wang Sicheng, Liu Guodong, Li Mengmeng, Su Jiacan. (2022) Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35813995] |
24. Kai-Yuan Huang, Wen-Hui Weng, Xin Huang, Hong-Xiang Huang, Hamada A. A. Noreldeen, Hao-Hua Deng, Wei Chen. (2022) Gold Nanocluster-Based Fluorometric Banoxantrone Assay Enabled by Photoinduced Electron Transfer. Nanomaterials, 12 (11): (1861). [PMID:35683717] |
25. Dadong Liang, Xingyi Tian, Yupeng Zhang, Guanya Zhu, Qiang Gao, Junbo Liu, Xiaoxiao Yu. (2022) A Weed-Derived Hierarchical Porous Carbon with a Large Specific Surface Area for Efficient Dye and Antibiotic Removal. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (11): (6146). [PMID:35682825] |
26. Chen Hui, Zheng Huizhen, Li Tiejun, Jiang Qihong, Liu Shulai, Zhou Xuxia, Ding Yuting, Xiang Xingwei. (2022) Protective Effect of Oyster Peptides Derived From Crassostrea gigas on Intestinal Oxidative Damage Induced by Cyclophosphamide in Mice Mediated Through Nrf2-Keap1 Signaling Pathway. Frontiers in Nutrition, 9 [PMID:35651503] |
27. Jingyu Ren, Zhouzhou Yao, Qian Wei, Ruotong Wang, Long Wang, Yuan Liu, Zixi Ren, He Guo, Zhirui Niu, Jian Wang, Yanzhong Zhen. (2022) Catalytic degradation of chloramphenicol by water falling film dielectric barrier discharge and FeO catalyst. SEPARATION AND PURIFICATION TECHNOLOGY, 290 (120826). [PMID:] |
28. Chao Han, Ying Wang, Ruiying Liu, Beibei Ran, Weidong Li. (2022) Structural characterization and protective effect of Lonicerae flos polysaccharide on cyclophosphamide-induced immunosuppression in mice. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 230 (113174). [PMID:34999342] |
29. Peng Rui, Chen Wen, Zhou Qian. (2022) Electrochemical sensor for chloramphenicol based on copper nanodendrites and carbon nanotubes. IONICS, 28 (1): (451-462). [PMID:] |
30. Jingyu Ren, Huizi Song, He Guo, Zhouzhou Yao, Qian Wei, Keqi Jiao, Zhongyi Li, Chengcheng Zhong, Jian Wang, Yanzhong Zhen. (2021) Removal of chloramphenicol in water by an improved water falling film dielectric barrier discharge reactor: Performance, mechanism, degradation pathway and toxicity evaluation. Journal of Cleaner Production, 325 (129332). [PMID:] |
31. Yi Wu, Shuai Mao, Chun Liu, Fubin Pei, Fengyun Wang, Qingli Hao, Mingzhu Xia, Wu Lei. (2022) Enhanced degradation of chloramphenicol through peroxymonosulfate and visible light over Z-scheme Photocatalysts: Synergetic performance and mechanism insights. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 608 (322). [PMID:34628312] |
32. Huihui Wu, Jingjing Yan, Xin Xu, Qianhui Yuan, Jinhang Wang, Jun Cui, Aijun Lin. (2022) Synergistic effects for boosted persulfate activation in a designed Fe–Cu dual-atom site catalyst. CHEMICAL ENGINEERING JOURNAL, 428 (132611). [PMID:] |
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