Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C153376-250mg | 250mg | In stock | $63.90 | |
C153376-1g | 1g | In stock | $230.90 | |
C153376-5g | 5g | In stock | $1,036.90 | |
C153376-25g | 25g | In stock | $4,665.90 |
Androgen receptor antagonist
Synonyms | NCGC00091032-05 | CYPROTERONE ACETATE [JAN] | DTXSID5020366 | Cyprostat® | W-106262 | (acetyl-chloro-dimethyl-oxo-[?]yl) acetate | 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1.beta.,2.beta.)- | C 3412 | CY |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Androgen receptor antagonist (IC 50 = 7.1 nM). Competes with dihydrotestosterone at androgen receptor sites. Active in vivo and in vitro . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Progesterone receptor agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity. |
ALogP | 3.6 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(1S,2S,3S,5R,11R,12S,15R,16S)-15-acetyl-9-chloro-2,16-dimethyl-6-oxo-15-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dienyl] acetate |
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INCHI | InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1 |
InChi Key | UWFYSQMTEOIJJG-FDTZYFLXSA-N |
Canonical SMILES | CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C |
Isomeric SMILES | CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)[C@@H]5C[C@@H]5[C@]34C)Cl)C)OC(=O)C |
PubChem CID | 9880 |
Molecular Weight | 416.94 |
PubChem CID | 9880 |
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ChEMBL Ligand | CHEMBL139835 |
BindingDB Ligand | 50094569 |
Wikipedia | Cyproterone_acetate |
CAS Registry No. | 427-51-0 |
ChEBI | CHEBI:50743 |
NURSA Ligand | 10.1621/496ZOA3LLY |
RCSB PDB Ligand | CA4 |
PEP | cyproterone acetate |
DrugCentral Ligand | 766 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G1908052 | Certificate of Analysis | Apr 17, 2023 | C153376 |
L22071258 | Certificate of Analysis | Dec 09, 2022 | C153376 |
I2221283 | Certificate of Analysis | Jul 15, 2022 | C153376 |
I2221284 | Certificate of Analysis | Jul 15, 2022 | C153376 |
I2221285 | Certificate of Analysis | Jul 15, 2022 | C153376 |
I2221286 | Certificate of Analysis | Jul 15, 2022 | C153376 |
Solubility | Insoluble in water; Degree of Solubility in water: 52 mg/l 25 °C; Very soluble in dichloromethane,Acetone; Soluble in Methanol; Slightly soluble in Ethanol |
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Sensitivity | heat sensitive |
Specific Rotation[α] | 152° (C=1,CHCl3) |
Melt Point(°C) | 209 °C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H373:Causes damage to organs through prolonged or repeated exposure H312:Harmful in contact with skin H332:Harmful if inhaled H360:May damage fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P319:Get medical help if you feel unwell. |
Merck Index | 2774 |