Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
C113160-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $78.90 | |
C113160-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $335.90 | |
C113160-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $599.90 | |
C113160-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,199.90 |
Cell permeable actin polymerization inhibitor. Reversible K V 1.5 blocker.
Synonyms | CYTOCHALASIN B|Phomin|14930-96-2|cytochalasin-B|CHEBI:23527|Cytochalasin B (Phomin)|MLS000028816|3CHI920QS7|NSC-107658|24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-|SMR000058787|(1S,4E,6R,1 |
---|---|
Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat |
Storage Temp | Protected from light,Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Cytochalasin B is used in actin polymerization studies and cytological research. Cytochalasin B is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. As opposed to other Cytochalasins, cytochalasin A and Cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin B inhibits phagocytosis by both mononuclear phagocytes and polymorphonuclear leukocytes |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | (1S,4E,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione |
---|---|
INCHI | InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1 |
InChi Key | GBOGMAARMMDZGR-TYHYBEHESA-N |
Canonical SMILES | CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O |
Isomeric SMILES | C[C@@H]1CCC[C@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O |
WGK Germany | 3 |
RTECS | RO0205000 |
PubChem CID | 5311281 |
UN Number | 1544 |
Molecular Weight | 479.61 |
Beilstein | 1096207 |
PubChem CID | 5311281 |
---|---|
Wikipedia | Cytochalasin_B |
CAS Registry No. | 14930-96-2 |
ChEBI | CHEBI:23527 |
ChEMBL Ligand | CHEMBL411729 |
RCSB PDB Ligand | 5RH |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2413227 | Certificate of Analysis | Apr 11, 2024 | C113160 |
E2413564 | Certificate of Analysis | Apr 11, 2024 | C113160 |
E2413565 | Certificate of Analysis | Apr 11, 2024 | C113160 |
K2223187 | Certificate of Analysis | Nov 04, 2022 | C113160 |
K2223248 | Certificate of Analysis | Nov 04, 2022 | C113160 |
K2223249 | Certificate of Analysis | Nov 04, 2022 | C113160 |
G2229084 | Certificate of Analysis | Jul 20, 2022 | C113160 |
G2229085 | Certificate of Analysis | Jul 20, 2022 | C113160 |
Solubility | Soluble in methanol (20 mg/ml), and 1:20 DMF:PBS(7.2) (~0.05 mg/ml). |
---|---|
Sensitivity | Heat sensitive;Light sensitive;Moisture sensitive |
Melt Point(°C) | 218-223°C |
Pictogram(s) | GHS06, GHS08 |
---|---|
Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P302+P350:IF ON SKIN: Gently wash with plenty of soap and water. |
WGK Germany | 3 |
RTECS | RO0205000 |
Starting at $232.90
Starting at $169.90
Starting at $240.90
Starting at $110.90
Starting at $299.90
1. Takahashi K et al.. (2018) In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.. Sci Rep, 8 (15585). [PMID:30348987] |
2. Wang F et al.. (2021) MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.. EMBO Rep, 22 (7): (e52006). [PMID:34096155] |