Click Here for 5% Off Your First Aladdin Purchase!

Cytochalasin B - 98%, high purity , CAS No.14930-96-2

  • Moligand™
  • ≥98%
Item Number
C113160
Grouped product items
SKUSizeAvailabilityPrice Qty
C113160-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$78.90
C113160-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$335.90
C113160-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$599.90
C113160-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,199.90

Cell permeable actin polymerization inhibitor. Reversible K V 1.5 blocker.

View related series
Arp2/3 Complex Cytoskeleton

Basic Description

SynonymsCYTOCHALASIN B|Phomin|14930-96-2|cytochalasin-B|CHEBI:23527|Cytochalasin B (Phomin)|MLS000028816|3CHI920QS7|NSC-107658|24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-|SMR000058787|(1S,4E,6R,1
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsOne of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Cytochalasin B is used in actin polymerization studies and cytological research. Cytochalasin B is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. As opposed to other Cytochalasins, cytochalasin A and Cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin B inhibits phagocytosis by both mononuclear phagocytes and polymorphonuclear leukocytes
A cell-permeable fungal toxin used in actin polymerization studies and cytological

Associated Targets

SLC2A3 Tchem Solute carrier family 2, facilitated glucose transporter member 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RAB9A Tbio Ras-related protein Rab-9A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC2A2 Tchem Solute carrier family 2, facilitated glucose transporter member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC2A4 Tchem Solute carrier family 2, facilitated glucose transporter member 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ITGAL Tclin Integrin alpha-L 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NPC1 Tchem NPC intracellular cholesterol transporter 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (1S,4E,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione
INCHI InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChi Key GBOGMAARMMDZGR-TYHYBEHESA-N
Canonical SMILES CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O
Isomeric SMILES C[C@@H]1CCC[C@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O
WGK Germany 3
RTECS RO0205000
PubChem CID 5311281
UN Number 1544
Molecular Weight 479.61
Beilstein 1096207

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot NumberCertificate TypeDateItem
E2413227Certificate of AnalysisApr 11, 2024 C113160
E2413564Certificate of AnalysisApr 11, 2024 C113160
E2413565Certificate of AnalysisApr 11, 2024 C113160
K2223187Certificate of AnalysisNov 04, 2022 C113160
K2223248Certificate of AnalysisNov 04, 2022 C113160
K2223249Certificate of AnalysisNov 04, 2022 C113160
G2229084Certificate of AnalysisJul 20, 2022 C113160
G2229085Certificate of AnalysisJul 20, 2022 C113160

Chemical and Physical Properties

SolubilitySoluble in methanol (20 mg/ml), and 1:20 DMF:PBS(7.2) (~0.05 mg/ml).
SensitivityHeat sensitive;Light sensitive;Moisture sensitive
Melt Point(°C)218-223°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H300:Fatal if swallowed

H310:Fatal in contact with skin

H330:Fatal if inhaled

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P302+P350:IF ON SKIN: Gently wash with plenty of soap and water.

WGK Germany 3
RTECS RO0205000

Related Documents

Alternative Products

References

1. Takahashi K et al..  (2018)  In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization..  Sci Rep,  (15585).  [PMID:30348987]
2. Wang F et al..  (2021)  MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking..  EMBO Rep,  22  (7): (e52006).  [PMID:34096155]

Solution Calculators