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Cytochalasin B from Drechslera dematioidea - Ready Made Solution, 10mg/mL in DMSO, high purity , CAS No.14930-96-2

8 Citations

Moligand™

Ready Made Solution, 10mg/mL in DMSO

CAS#: 14930-96-2
Formula: C₂₉H₃₇NO₅
Molecular Weight: 479.61
Beilstein Registry Number: 1096207
EC Number: 239-000-2
MDL number: MFCD00077704
PubChem CID: 5311281

Item Number

C485504

Grouped product items
SKU	Size	Availability	Price	Qty
C485504-200μl	200μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$394.90

Basic Description

Synonyms	C19954 \| IDI1_034070 \| MLS002703001 \| SCHEMBL9046718 \| 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)- \| BDBM
Specifications & Purity	Moligand™, Ready Made Solution, 10mg/mL in DMSO
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Cytochalasin B from Drechslera dematioidea has been used: to block cytokinesis, to obtain binucleated cells as a specific glucose transporter inhibitor to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells Cytochalasin B is used to inhibit sugar transport in fibroblasts , decrease cytoskeletal actin and myosin in rabbit neutrophils, and to stimulate B lymphocytes.

Associated Targets(Human)

MAOA Tclin Monoamine oxidase A (11911 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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MAOB Tclin Monoamine oxidase B (8835 Activities)

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ITGAL Tclin Leukocyte adhesion glycoprotein LFA-1 alpha (170 Activities)

Discover Target: ITGAL

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SLC2A1 Tchem Glucose transporter (14755 Activities)

Discover Target: SLC2A1

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A498 (42825 Activities)

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HL-60 (67320 Activities)

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MCF7 (126967 Activities)

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SK-MEL-2 (46422 Activities)

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SK-OV-3 (52876 Activities)

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XF498 (12972 Activities)

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A549 (127892 Activities)

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HCT-116 (91556 Activities)

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HepG2 (196354 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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HCT-15 (51914 Activities)

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SLC2A3 Tchem Solute carrier family 2, facilitated glucose transporter member 3 (465 Activities)

Discover Target: SLC2A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC2A2 Tchem Solute carrier family 2, facilitated glucose transporter member 2 (428 Activities)

Discover Target: SLC2A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC2A4 Tchem Solute carrier family 2, facilitated glucose transporter member 4 (396 Activities)

Discover Target: SLC2A4

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LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

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NPC1 Tchem Niemann-Pick C1 protein (18985 Activities)

Discover Target: NPC1

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RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)

Discover Target: RAB9A

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

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ITGAL Tclin Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (760 Activities)

Discover Target: ITGAL

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Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

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Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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Vibrio parahaemolyticus (473 Activities)

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CHO (4503 Activities)

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RAW264.7 (28094 Activities)

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Vero (26788 Activities)

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C6 (2371 Activities)

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H4 (48 Activities)

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

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TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cirsium arvense (30 Activities)

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Sonchus arvensis (14 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1S,4E,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione
INCHI	InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChi Key	GBOGMAARMMDZGR-TYHYBEHESA-N
Canonical SMILES	CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O
Isomeric SMILES	C[C@@H]1CCC[C@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O
WGK Germany	3
RTECS	RO0205000
PubChem CID	5311281
UN Number	1544
Molecular Weight	479.61
Beilstein	1096207

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Melt Point(°C)	218-223°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H300:Fatal if swallowed H310:Fatal in contact with skin H330:Fatal if inhaled H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P302+P350:IF ON SKIN: Gently wash with plenty of soap and water.
WGK Germany	3
RTECS	RO0205000

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yaqi Feng, Mi Li. (2023) Micropipette-assisted atomic force microscopy for single-cell 3D manipulations and nanomechanical measurements. Nanoscale, [PMID:37526589]
2. Yuying Bai, Dawei Tian, Zhengxin Ren, Dangyang Yue, Qian Ren, Li Pei, Jun Pan. (2023) The dependences of mesenchymal stem cells commitments on the size, concentration, internalization and exposure time of Iron Oxide Nanoparticles through F-actin, Lamin A and ROS. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, [PMID:36939155]
3. Xinyue Li, Yuanyuan Fan, Zhengbao Zha, Deyan Gong, Jiajia Yu, Qianhui Li, Ruoyao Li, Hua Wang, Fei Wang. (2023) Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation. ADVANCED FUNCTIONAL MATERIALS, 33 (18): (2214059). [PMID:]
4. Sun Xiaoxi, Huang Bing, Pan Yuping, Fang Jinhua, Wang Hefeng, Ji Yanru, Ling Yingchen, Guo Pei, Lin Jiangguo, Li Quhuan, Fang Ying, Wu Jianhua. (2022) Spatiotemporal characteristics of P-selectin-induced β2 integrin activation of human neutrophils under flow. Frontiers in Immunology, 13 [PMID:36439190]
5. Luchun Zhang, Meng Yuan, Xingwei Huang, Qianzi Cao, Shaogang Huang, Ruizhen Sun, Lei Lei. (2022) Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos. REPRODUCTION, 164 (5): (221-230). [PMID:36111643]
6. Zhe Chen, Qing Luo, Chuanchuan Lin, Dongdong Kuang, Guanbin Song. (2016) Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation.. Scientific Reports, 6 (30322-30322). [PMID:27444891]
7. Gu Haiping, Lou Jun, Wang Haizhen, Yang Yu, Wu Laosheng, Wu Jianjun, Xu Jianming. (2016) Biodegradation, Biosorption of Phenanthrene and Its Trans-Membrane Transport by Massilia sp. WF1 and Phanerochaete chrysosporium. Frontiers in Microbiology, 7 [PMID:26858710]
8. Y.N. Lin, R. Jia, Y.H. Liu, Y. Gao, L.L. Wang, J.P. Kou, B.Y. Yu. (2015) Ruscogenin suppresses mouse neutrophil activation: Involvement of protein kinase A pathway. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 154 (85). [PMID:26134424]

References

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35. Tomasz Brzoska,Yuko Suzuki,Hideo Mogami,Hideto Sano,Tetsumei Urano. (2013-02-06) Binding of thrombin-activated platelets to a fibrin scaffold through α(IIb)β₃ evokes phosphatidylserine exposure on their cell surface.. PloS one, 8 ((2)): (e55466-e55466). [PMID:23383331]
36. Ming-Chang Lin,Bo-Wei Chen,Chiung-Yao Huang,Chang-Feng Dai,Tsong-Long Hwang,Jyh-Horng Sheu. (2013-09-12) Eunicellin-based diterpenoids from the Formosan soft coral Klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils.. Journal of natural products, 76 ((9)): (1661-1667). [PMID:24020806]
37. Shudi Tang,Fatiha Tabet,Blake J Cochran,Luisa F Cuesta Torres,Ben J Wu,Philip J Barter,Kerry-Anne Rye. (2019-02-06) Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle.. Scientific reports, 9 ((1)): (1350-1350). [PMID:30718702]
38. Ryutaro Aizawa,Megumi Ibayashi,Tomomi Hatakeyama,Takayuki Tatsumi,Satoshi Tsukamoto. (2020-10-20) Impact of short-term high-fat feeding on lipid droplet content in mouse oocytes.. The Journal of reproduction and development, 67 ((1)): (73-77). [PMID:33071247]
39. Danielle Minns,Katie J Smith,Virginia Alessandrini,Gareth Hardisty,Lauren Melrose,Lucy Jackson-Jones,Andrew S MacDonald,Donald J Davidson,Emily Gwyer Findlay. (2021-02-26) The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation.. Nature communications, 12 ((1)): (1285-1285). [PMID:33627652]
40. Yaqi Feng, Mi Li. (2023) Micropipette-assisted atomic force microscopy for single-cell 3D manipulations and nanomechanical measurements. Nanoscale, [PMID:37526589]
41. Yuying Bai, Dawei Tian, Zhengxin Ren, Dangyang Yue, Qian Ren, Li Pei, Jun Pan. (2023) The dependences of mesenchymal stem cells commitments on the size, concentration, internalization and exposure time of Iron Oxide Nanoparticles through F-actin, Lamin A and ROS. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, [PMID:36939155]
42. Xinyue Li, Yuanyuan Fan, Zhengbao Zha, Deyan Gong, Jiajia Yu, Qianhui Li, Ruoyao Li, Hua Wang, Fei Wang. (2023) Cordycepin-Loaded Macrophage Vesicles for Targeted Nonalcoholic Steatohepatitis Attenuation. ADVANCED FUNCTIONAL MATERIALS, 33 (18): (2214059). [PMID:]
43. Sun Xiaoxi, Huang Bing, Pan Yuping, Fang Jinhua, Wang Hefeng, Ji Yanru, Ling Yingchen, Guo Pei, Lin Jiangguo, Li Quhuan, Fang Ying, Wu Jianhua. (2022) Spatiotemporal characteristics of P-selectin-induced β2 integrin activation of human neutrophils under flow. Frontiers in Immunology, 13 [PMID:36439190]
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Cytochalasin B from Drechslera dematioidea - Ready Made Solution, 10mg/mL in DMSO, high purity , CAS No.14930-96-2

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