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Cytochalasin D - 98%, high purity , CAS No.22144-77-0

31 Citations
  • ≥98%
Item Number
C102396
Grouped product items
SKUSizeAvailabilityPrice Qty
C102396-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
C102396-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,029.90
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Potent actin polymerization inhibitor

View related series
Anti-infection Antibiotic Arp2/3 Complex Cytoskeleton Stem Cell/Wnt YAP

Basic Description

SynonymsLygosporin A | MFCD00077706 | SY9F0FZ3TO | NSC209835 | Zygosporin A | (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)- 7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPotent actin polymerization inhibitor. Binds to G- and F-actin. Stimulates actin depolymerization. Induces cell cycle arrest at G1-S. Activates p53-dependent pathways. Cell permeable.
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Cytochalasin D is a cell permeable mycotoxin, which causes both the association and dissociation of actin subunits. Cytochalasin D disrupts actin filaments and inhibits actin polymerization.
Cytochalasins are used as tools in cytological research, and in the field of actin polymerization. Cytochalasin D is 10 times more effective than cytochalasin B and does not inhibit glucose transport across cell membranes.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ramos (1218 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Jurkat (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW-620 (52400 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TLR2 Tchem Toll-like receptor 1/2 (401 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Balamuthia mandrillaris (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABC1 ATP binding cassette transporter Abc1p (50 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(1R,2R,3E,5R,7S,9E,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate
INCHI InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
InChi Key SDZRWUKZFQQKKV-JHADDHBZSA-N
Canonical SMILES CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O
Isomeric SMILES C[C@H]1C/C=C/[C@H]2[C@@H](C(=C)[C@H]([C@@H]3[C@@]2([C@@H](/C=C/[C@@](C1=O)(C)O)OC(=O)C)C(=O)N[C@H]3CC4=CC=CC=C4)C)O
WGK Germany 3
RTECS GZ4850000
PubChem CID 5458428
UN Number 3172
Packing Group I
Molecular Weight 507.62
Beilstein 1632828

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
K2429629Certificate of AnalysisJul 11, 2024 C102396
K2429630Certificate of AnalysisJul 11, 2024 C102396
E2430043Certificate of AnalysisJun 05, 2024 C102396
F2122089Certificate of AnalysisApr 03, 2024 C102396
J2029136Certificate of AnalysisAug 07, 2023 C102396
K2205172Certificate of AnalysisOct 11, 2022 C102396
C1908026Certificate of AnalysisJan 21, 2022 C102396
L2320019Certificate of AnalysisMar 20, 2021 C102396

Chemical and Physical Properties

SolubilityDMSO, Ethanol, Methanol
SensitivityMoisture sensitive;Light sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H300:Fatal if swallowed

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

WGK Germany 3
RTECS GZ4850000
Class 6.1

Related Documents

 SDS

 Specification Sheet

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Citations of This Product

How to Cite Aladdin Scientific Products?
1. Xiaowei Wang, Mengyan Wang, Meilian Cai, Rongguang Shao, Guimin Xia, Wuli Zhao.  (2023)  Miriplatin-loaded liposome, as a novel mitophagy inducer, suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication.  Acta Pharmaceutica Sinica B,      [PMID:37969736] [10.1016/j.apsb.2023.07.009]
2. Zheng Dong, Juan Ma, Jiahuang Qiu, Quanzhong Ren, Qing’e Shan, Xuefeng Duan, Guangle Li, Yi Y. Zuo, Yu Qi, Yajun Liu, Guoliang Liu, Iseult Lynch, Min Fang, Sijin Liu.  (2023)  Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs.  Science Advances,  9  (23):   [PMID:37294770] [10.1126/sciadv.adf2165]
3. Liqun Huang, Ge Sun, Wenli Xu, Shufang Li, Xiujun Qin, Quan An, Zhongwen Wang, Jianguo Li.  (2023)  Uranium uptake is mediated markedly by clathrin-mediated endocytosis and induce dose-dependent toxicity in HK-2 cells.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,  101  (104171).  [PMID:37295740] [10.1016/j.etap.2023.104171]
4. Fa Dai, Ming Guo, Yina Shao, Chenghua Li.  (2023)  Novel secreted STPKLRR from Vibrio splendidus AJ01 promotes pathogen internalization via mediating tropomodulin phosphorylation dependent cytoskeleton rearrangement.  PLoS Pathogens,  19  (5): (e1011419).  [PMID:37216400] [10.1371/journal.ppat.1011419]
5. Shengnan Ma, Lei Song, Yueyue Bai, Shihao Wang, Jiao Wang, Haohao Zhang, Fazhan Wang, Yiyan He, Chuntao Tian, Guijun Qin.  (2023)  Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs.  RSC Advances,  13  (17): (11269-11277).  [PMID:37057265] [10.1039/D3RA00300K]
6. Wu Wenting, Ding Quan, Zhou Zhiwei, Kuang Wenliang, Jiang Lipeng, Liu Peng, Ai Weiping, Zhu Weifeng.  (2023)  Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios.  AAPS PHARMSCITECH,  24  (2): (1-16).  [PMID:36792796] [10.1208/s12249-022-02454-y]
7. Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen.  (2023)  Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway.  Toxins,  15  (2): (132).  [PMID:36828446] [10.3390/toxins15020132]
8. Liqun Huang, Shufang Li, Wenhua Zhou, Jie Gao, Jingjing Yin, Zhongwen Wang, Jianguo Li.  (2022)  Cellular transport of uranium and its cytotoxicity effects on CHO-k1 cells.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  246  (114166).  [PMID:36228352] [10.1016/j.ecoenv.2022.114166]
9. Zhuxian Wang, Yaqi Xue, Quanfu Zeng, Zhaoming Zhu, Yuan Wang, Yufan Wu, Chunyan Shen, Hongxia Zhu, Cuiping Jiang, Li Liu, Qiang Liu.  (2022)  Glycyrrhiza acid-Licochalcone A complexes for enhanced bioavailability and anti-melanogenic effect of Licochalcone A: cellular uptake and in vitro experiments.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  68  (103037).  [PMID:] [10.1016/j.jddst.2021.103037]
10. Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li.  (2021)  A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin.  PLoS Pathogens,  17  (12): (e1010145).  [PMID:34898657] [10.1371/journal.ppat.1010145]
11. Tan Yanjie, Jin Yi, Zhao Pengxiang, Wu Jian, Ren Zhuqing.  (2021)  Lipid droplets contribute myogenic differentiation in C2C12 by promoting the remodeling of the acstin-filament.  Cell Death & Disease,  12  (12): (1-13).  [PMID:34815388] [10.1038/s41419-021-04273-8]
12. Han Yijing, Hu Gege, Chen Yuying, Chen Lizhu, Yu Daode, Zhang Qianqian, Yang Dinglong.  (2021)  Antimicrobial Defensin and DNA Traps in Manila Clam Ruditapes philippinarum: Implications for Their Roles in Immune Responses.  Frontiers in Marine Science,  8    [PMID:] [10.3389/fmars.2021.690879]
13. Yu Zhang, Junxi Liu, Pengfei Dou, Zhijing Wu, Ziming Zheng, Xianglin Pan, Tao Zhou, Kaiping Wang.  (2021)  Oral absorption characteristics and mechanisms of a pectin-type polysaccharide from Smilax china L. across the intestinal epithelium.  CARBOHYDRATE POLYMERS,  270  (118383).  [PMID:34364625] [10.1016/j.carbpol.2021.118383]
14. Yijing Han, Qianqian Zhang, Lizhu Chen, Dinglong Yang, Jianmin Zhao.  (2021)  Mitochondria are essential for antibacterial extracellular trap formation mediated by zymosan in hemocytes of Ruditapes philippinarum.  DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,  121  (104094).  [PMID:33823212] [10.1016/j.dci.2021.104094]
15. Kai Lin, Zhao Ma, Mythili Ramachandran, Cristabelle De Souza, Xue Han, Lan-wei Zhang.  (2020)  ACE inhibitory peptide KYIPIQ derived from yak milk casein induces nitric oxide production in HUVECs and diffuses via a transcellular mechanism in Caco-2 monolayers.  PROCESS BIOCHEMISTRY,  99  (103).  [PMID:] [10.1016/j.procbio.2020.08.031]
16. Wendiao Zhang, Jiaxuan Gu, Yuanfang Li, Wenzhe Shan, Yingxuan Xu, Yong Chen.  (2020)  Single-vesicle tracking reveals the potential correlation of the movement of cell-bound membrane vesicles (CBMVs) with cell migration.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,  1867  (118804).  [PMID:32738252] [10.1016/j.bbamcr.2020.118804]
17. Yiyuan Kang, Jia Liu, Suhan Yin, Yanping Jiang, Xiaoli Feng, Junrong Wu, Yanli Zhang, Aijie Chen, Yaqing Zhang, Longquan Shao.  (2020)  Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.  ACS Nano,  14  (3): (3059–3074).  [PMID:32057235] [10.1021/acsnano.9b08078]
18. Jian Wang, Yangyang Li, Shouyu Wang, Fei Liu.  (2020)  Dynamics of transmissible gastroenteritis virus internalization unraveled by single-virus tracking in live cells.  FASEB JOURNAL,  34  (3): (4653-4669).  [PMID:32017270] [10.1096/fj.201902455R]
19. Dayong Chen, Hai Qiao, Yiting Wang, Ling Zhou, Na Yin, Liaoqiong Fang, Zhibiao Wang.  (2020)  Adenomyosis-derived extracellular vesicles endow endometrial epithelial cells with an invasive phenotype through epithelial-mesenchymal transition.  Genes & Diseases,  7  (636).  [PMID:33335963] [10.1016/j.gendis.2020.01.011]
20. Chen Xiaolong, Hu Cuihua, Zhang Yanan, Hao Wenjing, He Xu, Li Qing, Huang Yuxi, Huang Yibing, Chen Yuxin.  (2020)  Anticancer Activity and Mechanism of Action of kla-TAT Peptide.  International Journal of Peptide Research and Therapeutics,  26  (4): (2285-2296).  [PMID:] [10.1007/s10989-020-10019-5]
21. Zhao Yang, Sun Qing, Wang Shurong, Huo Bo.  (2019)  Spreading Shape and Area Regulate the Osteogenesis of Mesenchymal Stem Cells.  Tissue Engineering and Regenerative Medicine,  16  (6): (573-583).  [PMID:31824820] [10.1007/s13770-019-00213-y]
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15. Zheng Dong, Juan Ma, Jiahuang Qiu, Quanzhong Ren, Qing’e Shan, Xuefeng Duan, Guangle Li, Yi Y. Zuo, Yu Qi, Yajun Liu, Guoliang Liu, Iseult Lynch, Min Fang, Sijin Liu.  (2023)  Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs.  Science Advances,  9  (23):   [PMID:37294770] [10.1126/sciadv.adf2165]
16. Liqun Huang, Ge Sun, Wenli Xu, Shufang Li, Xiujun Qin, Quan An, Zhongwen Wang, Jianguo Li.  (2023)  Uranium uptake is mediated markedly by clathrin-mediated endocytosis and induce dose-dependent toxicity in HK-2 cells.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,  101  (104171).  [PMID:37295740] [10.1016/j.etap.2023.104171]
17. Fa Dai, Ming Guo, Yina Shao, Chenghua Li.  (2023)  Novel secreted STPKLRR from Vibrio splendidus AJ01 promotes pathogen internalization via mediating tropomodulin phosphorylation dependent cytoskeleton rearrangement.  PLoS Pathogens,  19  (5): (e1011419).  [PMID:37216400] [10.1371/journal.ppat.1011419]
18. Shengnan Ma, Lei Song, Yueyue Bai, Shihao Wang, Jiao Wang, Haohao Zhang, Fazhan Wang, Yiyan He, Chuntao Tian, Guijun Qin.  (2023)  Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs.  RSC Advances,  13  (17): (11269-11277).  [PMID:37057265] [10.1039/D3RA00300K]
19. Wu Wenting, Ding Quan, Zhou Zhiwei, Kuang Wenliang, Jiang Lipeng, Liu Peng, Ai Weiping, Zhu Weifeng.  (2023)  Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios.  AAPS PHARMSCITECH,  24  (2): (1-16).  [PMID:36792796] [10.1208/s12249-022-02454-y]
20. Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen.  (2023)  Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway.  Toxins,  15  (2): (132).  [PMID:36828446] [10.3390/toxins15020132]
21. Liqun Huang, Shufang Li, Wenhua Zhou, Jie Gao, Jingjing Yin, Zhongwen Wang, Jianguo Li.  (2022)  Cellular transport of uranium and its cytotoxicity effects on CHO-k1 cells.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  246  (114166).  [PMID:36228352] [10.1016/j.ecoenv.2022.114166]
22. Zhuxian Wang, Yaqi Xue, Quanfu Zeng, Zhaoming Zhu, Yuan Wang, Yufan Wu, Chunyan Shen, Hongxia Zhu, Cuiping Jiang, Li Liu, Qiang Liu.  (2022)  Glycyrrhiza acid-Licochalcone A complexes for enhanced bioavailability and anti-melanogenic effect of Licochalcone A: cellular uptake and in vitro experiments.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  68  (103037).  [PMID:] [10.1016/j.jddst.2021.103037]
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