Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C111218-1g | 1g | In stock | $142.90 | |
C111218-5g | 5g | In stock | $643.90 | |
C111218-25g | 25g | In stock | $2,895.90 | |
C111218-100g | 100g | In stock | $10,424.90 |
Pyrimidine nucleoside analog
Synonyms | Cytosar | Cytosine 1-beta-D-arabinofuranoside | Ara-cell | Cytosine arabinoside (VAN) | Cytosine-1-beta-arabinofuranoside | Cytarabine (USAN:USP:INN:BAN:JAN) | CYTARABINE (USP MONOGRAPH) | UNII-04079A1RDZ | Iretin | 1-beta-D-Arabinosylcytosine | 1beta-D-A |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Pyrimidine nucleoside analog able to inhibits DNA synthesis. Active specifically on the S phase of the cell cycle. Chemotherapeutic agent. Antiviral and immunosuppressant properties. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | DNA polymerase (alpha/delta/epsilon) inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | -2.1 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488180029 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180029 |
IUPAC Name | 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
INCHI | InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1 |
InChi Key | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
Canonical SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O |
Isomeric SMILES | C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O |
WGK Germany | 3 |
RTECS | HA5425000 |
PubChem CID | 6253 |
Molecular Weight | 243.22 |
Beilstein | 89175 |
Reaxy-Rn | 89175 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2408320 | Certificate of Analysis | Apr 02, 2024 | C111218 |
E2019049 | Certificate of Analysis | Mar 13, 2024 | C111218 |
E2326874 | Certificate of Analysis | Jan 09, 2023 | C111218 |
E2326877 | Certificate of Analysis | Jan 09, 2023 | C111218 |
E2326878 | Certificate of Analysis | Jan 09, 2023 | C111218 |
E2326879 | Certificate of Analysis | Jan 09, 2023 | C111218 |
E2326903 | Certificate of Analysis | Jan 09, 2023 | C111218 |
E2326905 | Certificate of Analysis | Jan 09, 2023 | C111218 |
E2326907 | Certificate of Analysis | Jan 09, 2023 | C111218 |
Solubility | Soluble in water |
---|---|
Specific Rotation[α] | 158 ° (C=1, H2O) |
Melt Point(°C) | 214°C |
Pictogram(s) | GHS08, GHS07 |
---|---|
Signal | Danger |
Hazard Statements | H317:May cause an allergic skin reaction H360:May damage fertility or the unborn child H340:May cause genetic defects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P281:Use personal protective equipment as required. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | HA5425000 |
Reaxy-Rn | 89175 |
Merck Index | 2784 |
Starting at $17.90
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1. Qiankun Quan, Xinxin Ma, Ming Li, Xi Li, Haifeng Yuan. (2024) Ginsenoside Rg1 promotes β‑amyloid peptide degradation through inhibition of the ERK/PPARγ phosphorylation pathway in an Alzheimer's disease neuronal model. Experimental and Therapeutic Medicine, 27 (1): (1-13). [PMID:38125359] [10.3892/etm.2023.12319] |
2. Yue-Ming Yu, Fan-Zhi Bu, Su-Su Meng, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li. (2023) The first nano-cocrystal formulation of marine drug cytarabine with uracil based on cocrystal nanonization strategy for long-acting injection exhibiting enhanced antitumor activity. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 644 (123300). [PMID:37567370] [10.1016/j.ijpharm.2023.123300] |
3. Lejiao Jia, Huatian Yang, Dandan Zheng, Jingjing Ye, Qian Zhou, Genjv Li, Ying Zhou, Xinyu Yang, Jinting Liu, Feng Ye, Yuliang Song, Daoxin Ma, Chunyan Ji. (2023) Smart and Generalizable Cytarabine Derivative-Triggered Nanoparticles for Synergistic Therapy of Relapsed/Refractory Acute Myeloid Leukemia. ACS Applied Materials & Interfaces, 15 (23): (27624–27637). [PMID:37249260] [10.1021/acsami.3c03632] |
4. Siyu Wang, Lutong Wang, Jingwen Xu, Yihai Wang, Limin Xiang, Xiangjiu He. (2023) Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (7): (3315–3324). [PMID:36752041] [10.1021/acs.jafc.2c07740] |
5. Wang Pengwei, Mao Senlin, Yi Tingting, Wang Lihua. (2023) LncRNA MALAT1 Targets miR-9-3p to Upregulate SAP97 in the Hippocampus of Mice with Vascular Dementia. BIOCHEMICAL GENETICS, 61 (3): (916-930). [PMID:36227424] [10.1007/s10528-022-10289-2] |
6. Jie Zhao, Yue Wu, Shanshan Liang, Xiangyu Piao. (2022) Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis. NEUROSCIENCE, 485 (78). [PMID:35090880] [10.1016/j.neuroscience.2022.01.017] |
7. Dan Shao, Qiang Gao, Yanshan Sheng, Shangji Li, Yong Kong. (2022) Construction of a dual-responsive dual-drug delivery platform based on the hybrids of mesoporous silica, sodium hyaluronate, chitosan and oxidized sodium carboxymethyl cellulose. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 202 (37). [PMID:35033530] [10.1016/j.ijbiomac.2022.01.033] |
8. Lefeng Liu, Zhiguo Xu, Yang Liu, Zheng-Zhi Yin, Yanshan Sheng, Chengqiang Ding, Yong Kong. (2021) Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine. Journal of Saudi Chemical Society, 25 (101344). [PMID:] [10.1016/j.jscs.2021.101344] |
9. Yuzhe Chen, Wenxuan Zhao, Honglian Dai. (2021) Porous PLGA-PEG nerve conduit decorated with oriented electrospun chitosan-RGD nanofibre. Journal of Materials Research and Technology-JMR&T, 15 (86). [PMID:] [10.1016/j.jmrt.2021.07.117] |
10. Kai Chen, Yong Qian, Chaoyang Wang, Dongjie Yang, Xueqing Qiu, Bernard P. Binks. (2021) Tumor microenvironment-responsive, high internal phase Pickering emulsions stabilized by lignin/chitosan oligosaccharide particles for synergistic cancer therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 591 (352). [PMID:33618293] [10.1016/j.jcis.2021.02.012] |
11. Qiang Gao, Jun Gao, Chengqiang Ding, Shangji Li, Linhong Deng, Yong Kong. (2021) Construction of a pH- and near-infrared irradiation-responsive nanoplatform for chemo-photothermal therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 593 (120112). [PMID:33259903] [10.1016/j.ijpharm.2020.120112] |
12. Yanshan Sheng, Wei Dai, Jun Gao, Hongda Li, Wensheng Tan, Jingwei Wang, Linhong Deng, Yong Kong. (2020) pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability. Materials Science & Engineering C-Materials for Biological Applications, 112 (110888). [PMID:32409046] [10.1016/j.msec.2020.110888] |
13. Zhigang Fang, Xiaozhen Wang, Yanling Sun, Ruifang Fan, Zhong Liu, Rui Guo, Deming Xie. (2019) Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia. Nanoscale, 11 (47): (23000-23012). [PMID:31769777] [10.1039/C9NR07391D] |
14. Jing Liu, Dujuan Zhao, Wenxiu He, Huiyuan Zhang, Zhonghao Li, Yuxia Luan. (2017) Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 487 (239). [PMID:27776282] [10.1016/j.jcis.2016.10.041] |
15. Jing Liu, Jing Liu, Dujuan Zhao, Naxin Ma, Yuxia Luan. (2016) Highly enhanced leukemia therapy and oral bioavailability from a novel amphiphilic prodrug of cytarabine. RSC Advances, 6 (42): (35991-35999). [PMID:] [10.1039/C6RA02051H] |
16. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du. (2017-06-07) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy.. Journal of biomaterials science. Polymer edition, 28 ((14)): (1603-1616). [PMID:28583017] |
1. Lautenschläger J et al.. (2018) An Easy-to-Implement Protocol for Preparing Postnatal Ventral Mesencephalic Cultures.. Front Cell Neurosci, 12 (44). [PMID:29556177] |
2. Qiankun Quan, Xinxin Ma, Ming Li, Xi Li, Haifeng Yuan. (2024) Ginsenoside Rg1 promotes β‑amyloid peptide degradation through inhibition of the ERK/PPARγ phosphorylation pathway in an Alzheimer's disease neuronal model. Experimental and Therapeutic Medicine, 27 (1): (1-13). [PMID:38125359] [10.3892/etm.2023.12319] |
3. Yue-Ming Yu, Fan-Zhi Bu, Su-Su Meng, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li. (2023) The first nano-cocrystal formulation of marine drug cytarabine with uracil based on cocrystal nanonization strategy for long-acting injection exhibiting enhanced antitumor activity. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 644 (123300). [PMID:37567370] [10.1016/j.ijpharm.2023.123300] |
4. Lejiao Jia, Huatian Yang, Dandan Zheng, Jingjing Ye, Qian Zhou, Genjv Li, Ying Zhou, Xinyu Yang, Jinting Liu, Feng Ye, Yuliang Song, Daoxin Ma, Chunyan Ji. (2023) Smart and Generalizable Cytarabine Derivative-Triggered Nanoparticles for Synergistic Therapy of Relapsed/Refractory Acute Myeloid Leukemia. ACS Applied Materials & Interfaces, 15 (23): (27624–27637). [PMID:37249260] [10.1021/acsami.3c03632] |
5. Siyu Wang, Lutong Wang, Jingwen Xu, Yihai Wang, Limin Xiang, Xiangjiu He. (2023) Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (7): (3315–3324). [PMID:36752041] [10.1021/acs.jafc.2c07740] |
6. Wang Pengwei, Mao Senlin, Yi Tingting, Wang Lihua. (2023) LncRNA MALAT1 Targets miR-9-3p to Upregulate SAP97 in the Hippocampus of Mice with Vascular Dementia. BIOCHEMICAL GENETICS, 61 (3): (916-930). [PMID:36227424] [10.1007/s10528-022-10289-2] |
7. Jie Zhao, Yue Wu, Shanshan Liang, Xiangyu Piao. (2022) Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis. NEUROSCIENCE, 485 (78). [PMID:35090880] [10.1016/j.neuroscience.2022.01.017] |
8. Dan Shao, Qiang Gao, Yanshan Sheng, Shangji Li, Yong Kong. (2022) Construction of a dual-responsive dual-drug delivery platform based on the hybrids of mesoporous silica, sodium hyaluronate, chitosan and oxidized sodium carboxymethyl cellulose. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 202 (37). [PMID:35033530] [10.1016/j.ijbiomac.2022.01.033] |
9. Lefeng Liu, Zhiguo Xu, Yang Liu, Zheng-Zhi Yin, Yanshan Sheng, Chengqiang Ding, Yong Kong. (2021) Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine. Journal of Saudi Chemical Society, 25 (101344). [PMID:] [10.1016/j.jscs.2021.101344] |
10. Yuzhe Chen, Wenxuan Zhao, Honglian Dai. (2021) Porous PLGA-PEG nerve conduit decorated with oriented electrospun chitosan-RGD nanofibre. Journal of Materials Research and Technology-JMR&T, 15 (86). [PMID:] [10.1016/j.jmrt.2021.07.117] |
11. Kai Chen, Yong Qian, Chaoyang Wang, Dongjie Yang, Xueqing Qiu, Bernard P. Binks. (2021) Tumor microenvironment-responsive, high internal phase Pickering emulsions stabilized by lignin/chitosan oligosaccharide particles for synergistic cancer therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 591 (352). [PMID:33618293] [10.1016/j.jcis.2021.02.012] |
12. Qiang Gao, Jun Gao, Chengqiang Ding, Shangji Li, Linhong Deng, Yong Kong. (2021) Construction of a pH- and near-infrared irradiation-responsive nanoplatform for chemo-photothermal therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 593 (120112). [PMID:33259903] [10.1016/j.ijpharm.2020.120112] |
13. Yanshan Sheng, Wei Dai, Jun Gao, Hongda Li, Wensheng Tan, Jingwei Wang, Linhong Deng, Yong Kong. (2020) pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability. Materials Science & Engineering C-Materials for Biological Applications, 112 (110888). [PMID:32409046] [10.1016/j.msec.2020.110888] |
14. Zhigang Fang, Xiaozhen Wang, Yanling Sun, Ruifang Fan, Zhong Liu, Rui Guo, Deming Xie. (2019) Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia. Nanoscale, 11 (47): (23000-23012). [PMID:31769777] [10.1039/C9NR07391D] |
15. Jing Liu, Dujuan Zhao, Wenxiu He, Huiyuan Zhang, Zhonghao Li, Yuxia Luan. (2017) Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 487 (239). [PMID:27776282] [10.1016/j.jcis.2016.10.041] |
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