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Cytosine β-D-arabinofuranoside hydrochloride - 10mM in DMSO, high purity , CAS No.69-74-9
Basic Description Synonyms CYTARABINE HYDROCHLORIDE | 69-74-9 | Cytosine arabinoside hydrochloride | Cytarabine HCl | 1-beta-D-Arabinofuranosylcytosine hydrochloride | Cytarabine hydrochloride [USAN] | U-19920A | Cytarabine (hydrochloride) | Ara-C hydrochloride | Cytosar hydrochloride | Cytosine-1-bet Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway.Does not inhibit Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride INCHI InChI=1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1 InChi Key KCURWTAZOZXKSJ-JBMRGDGGSA-N Canonical SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl Isomeric SMILES C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O.Cl WGK Germany 3 PubChem CID 6252 Molecular Weight 279.68
Chemical and Physical Properties Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H341: Suspected of causing genetic defects
H317: May cause an allergic skin reaction
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P281: Use personal protective equipment as required.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P203: Obtain, read and follow all safety instructions before use.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P318: if exposed or concerned, get medical advice.
P337+P317: If eye irritation persists: Get medical help.
WGK Germany 3
Citations of This Product 1. Andri Kurniawan Sutanto, Yuxin Xing, Tao Ding, Zhenqiang Wang, Kaiyao Sun, Dong Mo, Jixi Zhang, Kaiyong Cai. (2021) Hybrid mesoporous nanoparticles with highly integrated polydopamine for pH-responsive membrane permeation and drug delivery. Colloid and Interface Science Communications, 41 (100385). [PMID: [10.1016/j.colcom.2021.100385 ]
References 1. Andri Kurniawan Sutanto, Yuxin Xing, Tao Ding, Zhenqiang Wang, Kaiyao Sun, Dong Mo, Jixi Zhang, Kaiyong Cai. (2021) Hybrid mesoporous nanoparticles with highly integrated polydopamine for pH-responsive membrane permeation and drug delivery. Colloid and Interface Science Communications, 41 (100385). [PMID: [10.1016/j.colcom.2021.100385 ]
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