CZC24832 - ≥98%, high purity , CAS No.1159824-67-5, Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit gamma

Item Number

C128050

• Synonyms: CZC24832 | 1159824-67-5 | CZC 24832 | CZC-24832 | 5-(2-Amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide | 5-(2-amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)pyridine-3-sulfonamide | 5-{2-amino-8-fluoro-[1,2,4]tr
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Selective inhibitor of PI 3-kinaseγ(IC50= 1.0μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective i
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit gamma
• Note: 卖完停产，不再备货

Product Description

CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.