D-Aspartic acid - 98%, high purity , CAS No.1783-96-6, Excitatory amino acid transporter 1;Excitatory amino acid transporter 2;Excitatory amino acid transporter 3;Excitatory amino acid transporter 4;Excitatory amino acid transporter 5;Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agon

Item Number
A105951
Grouped product items
SKUSizeAvailabilityPrice Qty
A105951-25g
25g
In stock
$9.90
A105951-100g
100g
In stock
$14.90
A105951-250g
250g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$32.90
A105951-500g
500g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$68.90

NMDA agonist

Basic Description

Synonyms2,2'-methanediylbis(1H-benzimidazole) | 6-benzyloxy-1H-indole | C4H7NO4 | delta-aspartate | SR-01000597731 | C00402 | 7-Benzyloxy-1H-indole | BP-12717 | EN300-67412 | NCGC00024498-01 | Q27076990 | D-Aminosuccinic acid | MFCD0046411
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsEndogenous NMDA receptor agonist with similar activity to the L-isomer. Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.L-isomeralso available.
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionExcitatory amino acid transporter 1;Excitatory amino acid transporter 2;Excitatory amino acid transporter 3;Excitatory amino acid transporter 4;Excitatory amino acid transporter 5;Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agon
Note5g卖完停产,不再备货

Associated Targets(Human)

SLC1A1 Tchem Excitatory amino acid transporter 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC1A7 Tchem Excitatory amino acid transporter 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC1A3 Tchem Excitatory amino acid transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC1A6 Tchem Excitatory amino acid transporter 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC1A2 Tchem Excitatory amino acid transporter 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM6 Tchem Metabotropic glutamate receptor 6 (361 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM1 Tchem Metabotropic glutamate receptor 1 (2309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC1A3 Tchem Excitatory amino acid transporter 1 (586 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Grm2 Metabotropic glutamate receptor 2 (1326 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488186215
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488186215
IUPAC Name (2R)-2-aminobutanedioic acid
INCHI InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
InChi Key CKLJMWTZIZZHCS-UWTATZPHSA-N
Canonical SMILES C(C(C(=O)O)N)C(=O)O
Isomeric SMILES C([C@H](C(=O)O)N)C(=O)O
WGK Germany 1
RTECS CI9097500
Alternate CAS 1783-96-6,27881-01-2
PubChem CID 83887
MeSH Entry Terms 3-hydroxy-N-(2-methyl-1-oxo-2-propenyl)-;D Aspartate;D Aspartic Acid;D-Aspartate;D-Aspartic Acid
Molecular Weight 133.10
Beilstein 1723529
Reaxy-Rn 1723529

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
D2409159Certificate of AnalysisMar 20, 2024 A105951
D2409160Certificate of AnalysisMar 20, 2024 A105951
K1918152Certificate of AnalysisSep 05, 2023 A105951
B2324077Certificate of AnalysisJul 04, 2022 A105951
H2308230Certificate of AnalysisJul 04, 2022 A105951
H2412489Certificate of AnalysisJul 04, 2022 A105951
I2224076Certificate of AnalysisJul 04, 2022 A105951
I2224077Certificate of AnalysisJul 04, 2022 A105951
I2224078Certificate of AnalysisJul 04, 2022 A105951
I2224079Certificate of AnalysisJul 04, 2022 A105951
K2329235Certificate of AnalysisJul 04, 2022 A105951

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Chemical and Physical Properties

SolubilitySlightly soluble in water, Soluble in 1N ammonium hydroxide (100 mg/ml), and dilute HCl. Insoluble in ether, and alcohol.
Specific Rotation[α]-24.0 to -26.0 deg(C=8, HCl(1+1))
Melt Point(°C)300°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 1
RTECS CI9097500
Reaxy-Rn 1723529
Merck Index 840

Related Documents

Citations of This Product

1. Wei Jia, Xin Wang.  (2023)  3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner.  FOOD CHEMISTRY,  427  (136729).  [PMID:37385056] [10.1016/j.foodchem.2023.136729]
2. Yonglei Han, Chao Zhou, Shuchen Weng, Guicheng Yu, Fang Lin, Hanlin Hu, Yongfei Wang, Haoran Lin.  (2022)  Natural Product Additive with Multifunctional Groups Enhancing the Efficiency and Stability of Perovskite Solar Cells.  Solar RRL,  (4): (2200998).  [PMID:] [10.1002/solr.202200998]
3. Haoyuan Li, Hongxiang Zhu, Zongyan Quan, Zhiping Chen, Lei Wang, Hui He.  (2023)  Tailoring of a bionic bifunctional cellulose nanocrystal-based gold nanocluster probe for the detection of intracellular pathological biomarkers.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  224  (1079).  [PMID:36309238] [10.1016/j.ijbiomac.2022.10.192]
4. Shuli Liu, Xiaoling Wu, Jun Xiong, Xin Yuan, Min-Hua Zong, Wen-Yong Lou.  (2022)  Aspartic acid based metal–organic frameworks with dual function of NADH peroxidase and glycerol dehydrogenase-mimicking activities.  Materials Chemistry Frontiers,  (22): (3391-3401).  [PMID:] [10.1039/D2QM00770C]
5. Arabi Maryam, Ostovan Abbas, Wang Yunqing, Mei Rongchao, Fu Longwen, Li Jinhua, Wang Xiaoyan, Chen Lingxin.  (2022)  Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.  Nature Communications,  13  (1): (1-14).  [PMID:36180485] [10.1038/s41467-022-33448-w]
6. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,  243  (123363).  [PMID:35272154] [10.1016/j.talanta.2022.123363]
7. Lamei Yang, Feng Luo, Weili Wei.  (2021)  Simultaneous determination of the concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe.  Analytical Methods,  13  (16): (1905-1910).  [PMID:33913945] [10.1039/D1AY00271F]
8. Wen Luo, Huaxiao Liu, Xuan Liu, Lixiao Liu, Wenbo Zhao.  (2021)  Biocompatibility nanoprobe of MXene N-Ti3C2 quantum dot/Fe3+ for detection and fluorescence imaging of glutathione in living cells.  COLLOIDS AND SURFACES B-BIOINTERFACES,  201  (111631).  [PMID:33639506] [10.1016/j.colsurfb.2021.111631]
9. Yang Dan, Mei Shiliang, Wen Zhuoqi, Wei Xian, Cui Zhongjie, Yang Bobo, Wei Chang, Qiu Yi, Li Min, Li Hui, Zhang Wanlu, Xie Fengxian, Wang Le, Guo Ruiqian.  (2020)  Dual-emission of silicon nanoparticles encapsulated lanthanide-based metal-organic frameworks for ratiometric fluorescence detection of bacterial spores.  MICROCHIMICA ACTA,  187  (12): (1-9).  [PMID:33206253] [10.1007/s00604-020-04643-7]
10. Yanyang Zhu, Minxin Cui, Jiajun Ma, Qijin Zhang.  (2020)  Fluorescence detection of d-aspartic acid based on thiol-ene cross-linked molecularly imprinted optical fiber probe.  SENSORS AND ACTUATORS B-CHEMICAL,  305  (127323).  [PMID:] [10.1016/j.snb.2019.127323]
11. Yanni Miao, Qi Liu, Wei Wang, Li Liu, Li Wang.  (2017)  Enantioseparation of amino acids by micellar capillary electrophoresis using binary chiral selectors and determination of D-glutamic acid and D-aspartic acid in rice wine.  JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,      [PMID:] [10.1080/10826076.2017.1364263]
12. Chao Ding, Hanjun Sun, Jinsong Ren, Xiaogang Qu.  (2017)  Immobilization of enzyme on chiral polyelectrolyte surface.  ANALYTICA CHIMICA ACTA,  952  (88).  [PMID:28010846] [10.1016/j.aca.2016.11.047]

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10. Yuichi Kaji,Tetsuro Oshika,Yutaka Takazawa,Masashi Fukayama,Noriko Fujii.  (2012-06-15)  Co-localisation of advanced glycation end products and D-β-aspartic acid-containing proteins in gelatinous drop-like corneal dystrophy..  The British journal of ophthalmology,  96  ((8)): (1127-1131).  [PMID:22694960]
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12. Nobutoshi Ota,Ting Shi,Jonathan V Sweedler.  (2012-08-09)  D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems..  Amino acids,  43  ((5)): (1873-1886).  [PMID:22872108]
13. Jean-Marie Billard.  (2012-08-14)  D-Amino acids in brain neurotransmission and synaptic plasticity..  Amino acids,  43  ((5)): (1851-1860).  [PMID:22886346]
14. Masahiro Yamanaka,Yurika Miyoshi,Hiroko Ohide,Kenji Hamase,Ryuichi Konno.  (2012-08-16)  D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity..  Amino acids,  43  ((5)): (1811-1821).  [PMID:22892863]
15. Aiko Torikoshi-Hatano,Akira Namera,Hiroaki Shiraishi,Yousuke Arima,Hirokazu Toubou,Jiro Ezaki,Masami Morikawa,Masataka Nagao.  (2013-01-25)  Gender differences in D-aspartic acid content in skull bone..  Hiroshima journal of medical sciences,  61  ((4)): (91-100).  [PMID:23342826]
16. Edi Erwan,Vishwajit Sur Chowdhury,Mao Nagasawa,Ryosei Goda,Tsuyoshi Otsuka,Shinobu Yasuo,Mitsuhiro Furuse.  (2014-06-03)  Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks..  Life sciences,  109  ((1)): (65-71).  [PMID:24881518]
17. Hong-Fei Wang,Yong-Guang Zhang,Li Li,Wei-Hong Liu,Wael N Hozzein,Ji-Yue Chen,Jian-Wei Guo,Yuan-Ming Zhang,Wen-Jun Li.  (2015-01-09)  Okibacterium endophyticum sp. nov., a novel endophytic actinobacterium isolated from roots of Salsola affinis C. A. Mey..  Antonie van Leeuwenhoek,  107  ((3)): (835-843).  [PMID:25566956]
18. Massimo Venditti,Alessandra Santillo,Sara Falvo,Maria Maddalena Di Fiore,Gabriella Chieffi Baccari,Sergio Minucci.  (2020-05-02)  D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus..  Biomolecules,  10  ((5)):   [PMID:32353957]
19. Massimo Venditti,Maria Zelinda Romano,Francesco Aniello,Sergio Minucci.  (2021-01-14)  Preliminary Investigation on the Ameliorative Role Exerted by D-Aspartic Acid in Counteracting Ethane Dimethane Sulfonate (EDS) Toxicity in the Rat Testis..  Animals : an open access journal from MDPI,  11  ((1)):   [PMID:33435542]
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31. Wei Jia, Xin Wang.  (2023)  3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner.  FOOD CHEMISTRY,  427  (136729).  [PMID:37385056] [10.1016/j.foodchem.2023.136729]
32. Yonglei Han, Chao Zhou, Shuchen Weng, Guicheng Yu, Fang Lin, Hanlin Hu, Yongfei Wang, Haoran Lin.  (2022)  Natural Product Additive with Multifunctional Groups Enhancing the Efficiency and Stability of Perovskite Solar Cells.  Solar RRL,  (4): (2200998).  [PMID:] [10.1002/solr.202200998]
33. Haoyuan Li, Hongxiang Zhu, Zongyan Quan, Zhiping Chen, Lei Wang, Hui He.  (2023)  Tailoring of a bionic bifunctional cellulose nanocrystal-based gold nanocluster probe for the detection of intracellular pathological biomarkers.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  224  (1079).  [PMID:36309238] [10.1016/j.ijbiomac.2022.10.192]
34. Shuli Liu, Xiaoling Wu, Jun Xiong, Xin Yuan, Min-Hua Zong, Wen-Yong Lou.  (2022)  Aspartic acid based metal–organic frameworks with dual function of NADH peroxidase and glycerol dehydrogenase-mimicking activities.  Materials Chemistry Frontiers,  (22): (3391-3401).  [PMID:] [10.1039/D2QM00770C]
35. Arabi Maryam, Ostovan Abbas, Wang Yunqing, Mei Rongchao, Fu Longwen, Li Jinhua, Wang Xiaoyan, Chen Lingxin.  (2022)  Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.  Nature Communications,  13  (1): (1-14).  [PMID:36180485] [10.1038/s41467-022-33448-w]
36. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,  243  (123363).  [PMID:35272154] [10.1016/j.talanta.2022.123363]
37. Lamei Yang, Feng Luo, Weili Wei.  (2021)  Simultaneous determination of the concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe.  Analytical Methods,  13  (16): (1905-1910).  [PMID:33913945] [10.1039/D1AY00271F]
38. Wen Luo, Huaxiao Liu, Xuan Liu, Lixiao Liu, Wenbo Zhao.  (2021)  Biocompatibility nanoprobe of MXene N-Ti3C2 quantum dot/Fe3+ for detection and fluorescence imaging of glutathione in living cells.  COLLOIDS AND SURFACES B-BIOINTERFACES,  201  (111631).  [PMID:33639506] [10.1016/j.colsurfb.2021.111631]
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Solution Calculators