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A105951-25g

25g

In stock

$9.90

A105951-100g

100g

In stock

$14.90

A105951-250g

250g

Available within 4-8 weeks(?)

$32.90

A105951-500g

500g

Available within 8-12 weeks(?)

$68.90

Basic Description

Synonyms	D-Aspartic acid\|1783-96-6\|(R)-2-aminosuccinic acid\|D-Aspartate\|H-D-Asp-OH\|(2R)-2-aminobutanedioic acid\|(-)-Aspartic acid\|(R)-Aspartic acid\|D-(-)-Aspartic acid\|Aspartic acid D-form\|Aspartic acid, D-\|NSC 97922\|(R)-(-)-Aminosuccinic acid\|D-Asparaginsaeure\|BR
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Endogenous NMDA receptor agonist with similar activity to the L-isomer. Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.L-isomeralso available.
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Excitatory amino acid transporter 1;Excitatory amino acid transporter 2;Excitatory amino acid transporter 3;Excitatory amino acid transporter 4;Excitatory amino acid transporter 5;Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agon
Note	5g卖完停产，不再备货

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC1A1 Tchem Excitatory amino acid transporter 3 0 Activities

Discover Target: SLC1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC1A7 Tchem Excitatory amino acid transporter 5 0 Activities

Discover Target: SLC1A7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC1A3 Tchem Excitatory amino acid transporter 1 0 Activities

Discover Target: SLC1A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC1A6 Tchem Excitatory amino acid transporter 4 0 Activities

Discover Target: SLC1A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC1A2 Tchem Excitatory amino acid transporter 2 0 Activities

Discover Target: SLC1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

Discover Target: TSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM1 Tchem Metabotropic glutamate receptor 1 0 Activities

Discover Target: GRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM2 Tchem Metabotropic glutamate receptor 2 0 Activities

Discover Target: GRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM6 Tchem Metabotropic glutamate receptor 6 0 Activities

Discover Target: GRM6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN3A Tclin Glutamate receptor ionotropic, NMDA 3A 0 Activities

Discover Target: GRIN3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A 0 Activities

Discover Target: GRIN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B 0 Activities

Discover Target: GRIN2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities

Discover Target: GRIN2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D 0 Activities

Discover Target: GRIN2D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488186215
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488186215
IUPAC Name	(2R)-2-aminobutanedioic acid
INCHI	InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
InChi Key	CKLJMWTZIZZHCS-UWTATZPHSA-N
Canonical SMILES	C(C(C(=O)O)N)C(=O)O
Isomeric SMILES	C([C@H](C(=O)O)N)C(=O)O
WGK Germany	1
RTECS	CI9097500
Alternate CAS	1783-96-6,27881-01-2
PubChem CID	83887
MeSH Entry Terms	3-hydroxy-N-(2-methyl-1-oxo-2-propenyl)-;D Aspartate;D Aspartic Acid;D-Aspartate;D-Aspartic Acid
Molecular Weight	133.10
Beilstein	1723529
Reaxy-Rn	1723529

Database links

PubChem SID	488186215

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot Number	Certificate Type	Date	Item
D2409159	Certificate of Analysis	Mar 20, 2024	A105951
D2409160	Certificate of Analysis	Mar 20, 2024	A105951
K1918152	Certificate of Analysis	Sep 05, 2023	A105951
B2324077	Certificate of Analysis	Jul 04, 2022	A105951
H2308230	Certificate of Analysis	Jul 04, 2022	A105951
H2412489	Certificate of Analysis	Jul 04, 2022	A105951
I2224076	Certificate of Analysis	Jul 04, 2022	A105951
I2224077	Certificate of Analysis	Jul 04, 2022	A105951
I2224078	Certificate of Analysis	Jul 04, 2022	A105951
I2224079	Certificate of Analysis	Jul 04, 2022	A105951
K2329235	Certificate of Analysis	Jul 04, 2022	A105951

Chemical and Physical Properties

Solubility	Slightly soluble in water, Soluble in 1N ammonium hydroxide (100 mg/ml), and dilute HCl. Insoluble in ether, and alcohol.
Specific Rotation[α]	-24.0 to -26.0 deg(C=8, HCl(1+1))
Melt Point(°C)	300°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	1
RTECS	CI9097500
Reaxy-Rn	1723529
Merck Index	840

References

1. Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E. (2007) Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.. Nature, 445 (7126): (387-93). [PMID:17230192]
2. Rojas A et al.. (2014) The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.. Neurobiol Dis, 70 (74-89). [PMID:24952362]
3. H Homma. (2006-06-07) Biochemistry of D-aspartate in mammalian cells.. Amino acids, 32 ((1)): (3-11). [PMID:16755369]
4. Yuhei Mori,Kenzo Aki,Katsunori Kuge,Shingo Tajima,Natsuko Yamanaka,Yuichi Kaji,Naoki Yamamoto,Ryoji Nagai,Hanako Yoshii,Norihiko Fujii,Masami Watanabe,Tadatoshi Kinouchi,Noriko Fujii. (2011-06-04) UV B-irradiation enhances the racemization and isomerizaiton of aspartyl residues and production of Nε-carboxymethyl lysine (CML) in keratin of skin.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 ((29)): (3303-3309). [PMID:21636332]
5. Tadatoshi Kinouchi,Norihiko Fujii,Noriko Fujii. (2011-09-29) Substrate stereoselectivity of mammalian D-aspartyl endopeptidase.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 ((29)): (3349-3352). [PMID:21944696]
6. Francesco Errico,Alessandra Bonito-Oliva,Vincenza Bagetta,Daniela Vitucci,Rosaria Romano,Elisa Zianni,Francesco Napolitano,Silvia Marinucci,Monica Di Luca,Paolo Calabresi,Gilberto Fisone,Manolo Carta,Barbara Picconi,Fabrizio Gardoni,Alessandro Usiello. (2011-09-29) Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia.. Experimental neurology, 232 ((2)): (240-250). [PMID:21946266]
7. George H Fisher,Mara Tsesarskaia. (2011-10-01) HPLC methods for determination of D-aspartate and N-methyl-D-aspartate.. Methods in molecular biology (Clifton, N.J.), 794 (253-264). [PMID:21956568]
8. Edi Erwan,Shozo Tomonaga,Junki Yoshida,Mao Nagasawa,Yumi Ogino,D Michael Denbow,Mitsuhiro Furuse. (2012-04-03) Central administration of L- and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks.. Amino acids, 43 ((5)): (1969-1976). [PMID:22466305]
9. Silvia Holmseth,Yvette Dehnes,Yanhua H Huang,Virginie V Follin-Arbelet,Nina J Grutle,Maria N Mylonakou,Celine Plachez,Yun Zhou,David N Furness,Dwight E Bergles,Knut P Lehre,Niels C Danbolt. (2012-04-28) The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 ((17)): (6000-6013). [PMID:22539860]
10. Yuichi Kaji,Tetsuro Oshika,Yutaka Takazawa,Masashi Fukayama,Noriko Fujii. (2012-06-15) Co-localisation of advanced glycation end products and D-β-aspartic acid-containing proteins in gelatinous drop-like corneal dystrophy.. The British journal of ophthalmology, 96 ((8)): (1127-1131). [PMID:22694960]
11. Francesco Errico,Francesco Napolitano,Robert Nisticò,Alessandro Usiello. (2012-08-02) New insights on the role of free D-aspartate in the mammalian brain.. Amino acids, 43 ((5)): (1861-1871). [PMID:22851050]
12. Nobutoshi Ota,Ting Shi,Jonathan V Sweedler. (2012-08-09) D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems.. Amino acids, 43 ((5)): (1873-1886). [PMID:22872108]
13. Jean-Marie Billard. (2012-08-14) D-Amino acids in brain neurotransmission and synaptic plasticity.. Amino acids, 43 ((5)): (1851-1860). [PMID:22886346]
14. Masahiro Yamanaka,Yurika Miyoshi,Hiroko Ohide,Kenji Hamase,Ryuichi Konno. (2012-08-16) D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.. Amino acids, 43 ((5)): (1811-1821). [PMID:22892863]
15. Aiko Torikoshi-Hatano,Akira Namera,Hiroaki Shiraishi,Yousuke Arima,Hirokazu Toubou,Jiro Ezaki,Masami Morikawa,Masataka Nagao. (2013-01-25) Gender differences in D-aspartic acid content in skull bone.. Hiroshima journal of medical sciences, 61 ((4)): (91-100). [PMID:23342826]
16. Edi Erwan,Vishwajit Sur Chowdhury,Mao Nagasawa,Ryosei Goda,Tsuyoshi Otsuka,Shinobu Yasuo,Mitsuhiro Furuse. (2014-06-03) Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks.. Life sciences, 109 ((1)): (65-71). [PMID:24881518]
17. Hong-Fei Wang,Yong-Guang Zhang,Li Li,Wei-Hong Liu,Wael N Hozzein,Ji-Yue Chen,Jian-Wei Guo,Yuan-Ming Zhang,Wen-Jun Li. (2015-01-09) Okibacterium endophyticum sp. nov., a novel endophytic actinobacterium isolated from roots of Salsola affinis C. A. Mey.. Antonie van Leeuwenhoek, 107 ((3)): (835-843). [PMID:25566956]
18. Massimo Venditti,Alessandra Santillo,Sara Falvo,Maria Maddalena Di Fiore,Gabriella Chieffi Baccari,Sergio Minucci. (2020-05-02) D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and Induces Its Localization in Spermatogonia Nucleus.. Biomolecules, 10 ((5)): [PMID:32353957]
19. Massimo Venditti,Maria Zelinda Romano,Francesco Aniello,Sergio Minucci. (2021-01-14) Preliminary Investigation on the Ameliorative Role Exerted by D-Aspartic Acid in Counteracting Ethane Dimethane Sulfonate (EDS) Toxicity in the Rat Testis.. Animals : an open access journal from MDPI, 11 ((1)): [PMID:33435542]
20. Franca Raucci,Maria Maddalena Di Fiore. (2011-05-03) D-Asp: a new player in reproductive endocrinology of the amphibian Rana esculenta.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 ((29)): (3268-3276). [PMID:21531634]
21. Noriko Fujii,Yuichi Kaji,Norihiko Fujii. (2011-07-05) D-Amino acids in aged proteins: analysis and biological relevance.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 ((29)): (3141-3147). [PMID:21723211]
22. Ikuhiko Noji,Akifumi Oda,Kana Kobayashi,Ohgi Takahashi. (2011-07-12) Computational investigation of the substrate recognition mechanism of protein D-aspartyl (L-isoaspartyl) O-methyltransferase by docking and molecular dynamics simulation studies and application to interpret size exclusion chromatography data.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 ((29)): (3310-3316). [PMID:21741329]
23. Maria Summa,Silvia Di Prisco,Massimo Grilli,Mario Marchi,Anna Pittaluga. (2011-08-09) Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training.. Neuropharmacology, 61 ((8)): (1282-1290). [PMID:21820454]
24. Takehiko Yokoyama,Masafumi Amano,Masae Sekine,Hiroshi Homma,Masaharu Tokuda,Minoru Sato. (2011-08-09) Immunohistochemical localization of endogenous D-Aspartate in the marine brown Alga Sargassum fusiforme.. Bioscience, biotechnology, and biochemistry, 75 ((8)): (1481-1484). [PMID:21821953]
25. Akifumi Oda,Kana Kobayashi,Ohgi Takahashi. (2011-08-30) Comparison of molecular dynamics simulation methods for amyloid β(1-42) monomers containing D-aspartic acid residues for predicting retention times in chromatography.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 ((29)): (3337-3343). [PMID:21871847]
26. Paolo Bigini,Marco Milanese,Fabrizio Gardoni,Annalisa Longhi,Tiziana Bonifacino,Sara Barbera,Elena Fumagalli,Monica Di Luca,Tiziana Mennini,Giambattista Bonanno. (2012-02-04) Increased [³H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse.. Journal of neuroscience research, 90 ((6)): (1148-1158). [PMID:22302580]
27. Lavinia Burrone,Alessandra Santillo,Claudia Pinelli,Gabriella Chieffi Baccari,Maria Maddalena Di Fiore. (2012-07-10) Induced synthesis of P450 aromatase and 17β-estradiol by D-aspartate in frog brain.. The Journal of experimental biology, 215 ((Pt 20)): (3559-3565). [PMID:22771744]
28. Yuanqi Tao,Neil R Quebbemann,Ryan R Julian. (2012-07-21) Discriminating D-amino acid-containing peptide epimers by radical-directed dissociation mass spectrometry.. Analytical chemistry, 84 ((15)): (6814-6820). [PMID:22812429]
29. Jean-Pierre Mothet,Solomon H Snyder. (2012-09-19) Brain D-amino acids: a novel class of neuromodulators.. Amino acids, 43 ((5)): (1809-1810). [PMID:22986446]
30. Alessandra Santillo,Claudia Pinelli,Lavinia Burrone,Gabriella Chieffi Baccari,Maria Maddalena Di Fiore. (2012-11-17) D-Aspartic acid implication in the modulation of frog brain sex steroid levels.. General and comparative endocrinology, 181 (72-76). [PMID:23153651]

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