Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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B105433-1g | 1g | In stock | $19.90 | |
B105433-5g | 5g | In stock | $69.90 | |
B105433-10g | 10g | In stock | $108.90 | |
B105433-25g | 25g | In stock | $189.90 | |
B105433-100g | 100g | In stock | $529.90 | |
B105433-500g | 500g | In stock | $1,839.90 |
Enzyme co-factor. Protein conjugate for biochemical assays.
Synonyms | Bios II | 4bj8 | Acidum capobenicum [INN-Latin] | CHEBI:15956 | Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid, (3aS-(3aalpha,4beta,6aalpha))- | hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid | 2'-Keto-3,4-imidazolido-2-tetrahydrot |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Enzyme co-factor. Protein conjugate for biochemical assays. Participates in the citric acid cycle. Necessary for, and promotes cell growth, fatty acid production and the metabolism of fats and amino acids in vivo. Orally active.Biotin also acts as a cofac |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Essential vitamin that is important for amino acid and energy metabolism Application:
Biotin has been used for testing the functionality of the Avidin-displaying phages.The product has also been used for labeling the swine anti-rabbit IgG antibody and peroxidase.
It has been used for culturing of oligodendrocytes. It has been used as a vitamin supplement for the growth of Bacillus species. It has been used for blocking endogenous biotin during immunohistology procedures. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488188469 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488188469 |
IUPAC Name | 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid |
INCHI | InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1 |
InChi Key | YBJHBAHKTGYVGT-ZKWXMUAHSA-N |
Canonical SMILES | [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2 |
Isomeric SMILES | C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2 |
WGK Germany | 1 |
RTECS | XJ9088200 |
PubChem CID | 171548 |
Molecular Weight | 244.31 |
Beilstein | 86838 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2404490 | Certificate of Analysis | Nov 16, 2024 | B105433 |
L2404489 | Certificate of Analysis | Nov 16, 2024 | B105433 |
L2404484 | Certificate of Analysis | Nov 16, 2024 | B105433 |
J2431197 | Certificate of Analysis | Oct 14, 2024 | B105433 |
J2431151 | Certificate of Analysis | Oct 14, 2024 | B105433 |
J2431129 | Certificate of Analysis | Oct 14, 2024 | B105433 |
J2431063 | Certificate of Analysis | Oct 14, 2024 | B105433 |
H2408139 | Certificate of Analysis | Apr 03, 2024 | B105433 |
G2301058 | Certificate of Analysis | Nov 12, 2022 | B105433 |
K2330096 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2403045 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G23041054 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301064 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301053 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301051 | Certificate of Analysis | Nov 12, 2022 | B105433 |
C2426040 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301050 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301049 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301048 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301047 | Certificate of Analysis | Nov 12, 2022 | B105433 |
G2301052 | Certificate of Analysis | Nov 12, 2022 | B105433 |
J2217199 | Certificate of Analysis | Sep 14, 2022 | B105433 |
J2217202 | Certificate of Analysis | Sep 14, 2022 | B105433 |
J2217198 | Certificate of Analysis | Sep 14, 2022 | B105433 |
J2217197 | Certificate of Analysis | Sep 14, 2022 | B105433 |
G2230031 | Certificate of Analysis | Jul 12, 2022 | B105433 |
G2230030 | Certificate of Analysis | Jul 12, 2022 | B105433 |
G2230029 | Certificate of Analysis | Jul 12, 2022 | B105433 |
G2230028 | Certificate of Analysis | Jul 12, 2022 | B105433 |
B2225499 | Certificate of Analysis | Dec 16, 2021 | B105433 |
B2225626 | Certificate of Analysis | Dec 16, 2021 | B105433 |
B2225625 | Certificate of Analysis | Dec 16, 2021 | B105433 |
B2225622 | Certificate of Analysis | Dec 16, 2021 | B105433 |
Solubility | Solubility in water: 0.22 g/L (25°C) Solubility in other solvents: more soluble in hot water and dil. alkali 0.8 g/L alcohol insoluble in most other common organic solvents |
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Sensitivity | Light &heat Sensitive |
Specific Rotation[α] | 90.5 ° (C=2, 0.1mol/L NaOH) |
Melt Point(°C) | 232-233°C |
WGK Germany | 1 |
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RTECS | XJ9088200 |
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3. Yawen Zhang, Yue Wu, Yuping Yan, Yijing Ma, Linglan Tu, Jingjing Shao, Xuanyu Tang, Lingfeng Chen, Guang Liang, Lina Yin. (2023) Dual-Targeted Nanoparticle-In-Microparticle System for Ulcerative Colitis Therapy. Advanced Healthcare Materials, (2301518). [PMID:37660262] [10.1002/adhm.202301518] |
4. Xinran Wang, Jieyi Pan, Haohui Shi, Na Liang, Shaoping Sun. (2023) Biotin-modified acid-sensitive micelles for enhancing antitumor effect of paclitaxel. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 84 (104538). [PMID:] [10.1016/j.jddst.2023.104538] |
5. Wenjuan Dong, Lu Wang, Rongrong Zhang, Chaochao Wen, Ren Su, Xiaojuan Gong, Wenting Liang. (2023) High luminescent N,S,P co-doped carbon dots for the fluorescence sensing of extreme acidity and folic acid. DALTON TRANSACTIONS, 52 (19): (6551-6558). [PMID:37185994] [10.1039/D3DT00560G] |
6. Qunhuan Ma, Li Zhang. (2023) The influences of dissolved inorganic and organic phosphorus on arsenate toxicity in marine diatom Skeletonema costatum and dinoflagellate Amphidinium carterae. JOURNAL OF HAZARDOUS MATERIALS, 453 (131432). [PMID:37080037] [10.1016/j.jhazmat.2023.131432] |
7. Peiyun Cheng, Na Liang, Wei Zhao, Xianfeng Gong, Weijia Wang, Shaoping Sun. (2023) Chitosan-based near-infrared fluorescent micelles for controlled drug delivery and bioimaging in cancer therapy. EUROPEAN POLYMER JOURNAL, 189 (111974). [PMID:] [10.1016/j.eurpolymj.2023.111974] |
8. Ying Gao, Jie Zhang, Jiexia Pan, Sanjun Ying, Bang Lou, Qingliang Yang, Weiyong Hong, Gensheng Yang. (2023) FOF1-ATP synthase molecular motor biosensor for miRNA detection of colon cancer. LIFE SCIENCES, 319 (121527). [PMID:36841472] [10.1016/j.lfs.2023.121527] |
9. Xiao-lei Wang, Qi Wang, Ya-xian Xue, Bing Zhang, Shu-rui Han, Huan Zhang, Kong-yin Zhao, Wan Wang, Jun-fu Wei. (2023) Preparation of composite nanofiltration membrane with interlayer for pharmaceutical rejection. SEPARATION AND PURIFICATION TECHNOLOGY, 312 (123411). [PMID:] [10.1016/j.seppur.2023.123411] |
10. Bin Sun, Zhigang Wang, Bo Zhao, Yanfei Jin, Yaqiang Li, Song Yang. (2023) Preparation of biotin-labeled graphene film for detecting nerve growth factor. International Journal of Electrochemical Science, 18 (100029). [PMID:] [10.1016/j.ijoes.2023.01.029] |
11. Huihui Yang, Xiaosen Bai, Baolong Feng, Qinghua Wang, Li Meng, Fengzhong Wang, Yutang Wang. (2023) Application of Molecular Transformer approach for predicting the potential reactions to generate advanced glycation end products in infant formula. FOOD CHEMISTRY, 407 (135143). [PMID:36516683] [10.1016/j.foodchem.2022.135143] |
12. Qunhuan Ma, Lizhao Chen, Li Zhang. (2023) Effects of phosphate on the toxicity and bioaccumulation of arsenate in marine diatom Skeletonema costatum. SCIENCE OF THE TOTAL ENVIRONMENT, 857 (159566). [PMID:36265640] [10.1016/j.scitotenv.2022.159566] |
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14. Weng Chunyue, Mi Zheyan, Li Meijing, Qin Haibin, Hu Zhongce, Liu Zhiqiang, Zheng Yuguo, Wang Yuanshan. (2022) Improvement of S-adenosyl-L-methionine production in Saccharomyces cerevisiae by atmospheric and room temperature plasma-ultraviolet compound mutagenesis and droplet microfluidic adaptive evolution. 3 Biotech, 12 (9): (1-15). [PMID:35975026] [10.1007/s13205-022-03297-x] |
15. Dan Gao, Sajid Asghar, Junxiu Ye, Mei Zhang, Rongfeng Hu, Yadong Wang, Lin Huang, Chengjun Yuan, Zhipeng Chen, Yanyu Xiao. (2022) Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer. CARBOHYDRATE POLYMERS, 294 (119785). [PMID:35868795] [10.1016/j.carbpol.2022.119785] |
16. Chuanjiang Jian, Ying Wang, Huijun Liu, Zongning Yin. (2022) A biotin-modified and H2O2-activatable theranostic nanoplatform for enhanced photothermal and chemical combination cancer therapy. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 177 (24). [PMID:35667614] [10.1016/j.ejpb.2022.05.019] |
17. Lihua Chen, Pan Zhao, Jing Yang, Xiali Liao, Bo Yang, Chuanzhu Gao. (2022) Synthesis, characterization, and antitumor biological evaluation of novel fluorine-containing platinum (IV) complexes. APPLIED ORGANOMETALLIC CHEMISTRY, 36 (7): (e6759). [PMID:] [10.1002/aoc.6759] |
18. Yang Xu, Na Liang, Jiyang Liu, Xianfeng Gong, Pengfei Yan, Shaoping Sun. (2022) Design and fabrication of chitosan-based AIE active micelles for bioimaging and intelligent delivery of paclitaxel. CARBOHYDRATE POLYMERS, 290 (119509). [PMID:35550783] [10.1016/j.carbpol.2022.119509] |
19. Xiang Yingying, Song Fei, Jiang Lei, Liu Ze, Tu Yujiao. (2022) Novel Fluorescent Nano Carbon Quantum Dots Derived From Lactarius Hatsudake for High Selective Vitamin B12 Detection. JOURNAL OF AOAC INTERNATIONAL, 105 (5): (1350-1359). [PMID:35244160] [10.1093/jaoacint/qsac033] |
20. Jie Zhang, Boyou Zhang, Zefeng Zheng, Qingyun Cai, Jingcheng Wang, Qiang Shu, Lijia Wang. (2021) Tissue-Engineered Bone Functionalized with MoS2 Nanosheets for Enhanced Repair of Critical-Size Bone Defect in Rats. ADVANCED FUNCTIONAL MATERIALS, 32 (13): (2109882). [PMID:] [10.1002/adfm.202109882] |
21. Sida Ruan, Guiying Yang, Yuanzhen Dong, Wenwen Shangguan, Weigen Lu. (2021) Discovery of a Long-Acting Parathyroid Hormone 1–34 Analogue to Treat Hypoparathyroidism. MOLECULAR PHARMACEUTICS, 18 (9): (3260–3271). [PMID:34482698] [10.1021/acs.molpharmaceut.1c00149] |
22. Jing Lv, Meiqiang Xie, Shufen Zhao, Wensheng Qiu, Shasha Wang, Manming Cao. (2021) Synergetic fabrication of hybrid drug formulation using biodegradable tri-block copolymeric liquid nanoparticle delivery for gastric cancer chemotherapy. JOURNAL OF MOLECULAR LIQUIDS, 340 (117066). [PMID:] [10.1016/j.molliq.2021.117066] |
23. Zhao Wang, Bin Liu, Qianqian Sun, Lili Feng, Fei He, Piaoping Yang, Shili Gai, Zewei Quan, Jun Lin. (2021) Upconverted Metal–Organic Framework Janus Architecture for Near-Infrared and Ultrasound Co-Enhanced High Performance Tumor Therapy. ACS Nano, 15 (7): (12342–12357). [PMID:34160201] [10.1021/acsnano.1c04280] |
24. Haohui Shi, Na Liang, Jiyang Liu, Siyi Li, Xianfeng Gong, Pengfei Yan, Shaoping Sun. (2021) AIE-active polymeric micelles based on modified chitosan for bioimaging-guided targeted delivery and controlled release of paclitaxel. CARBOHYDRATE POLYMERS, 269 (118327). [PMID:34294339] [10.1016/j.carbpol.2021.118327] |
25. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 252 (119506). [PMID:33561684] [10.1016/j.saa.2021.119506] |
26. Xiuling Ji, Suping Wang, Yiyong Luo, Xiaotian Yuan, Yunlin Wei, Qi Zhang, Kunhao Qin, Yujiao Tu. (2021) Green synthesis of weissella-derived fluorescence carbon dots for microbial staining, cell imaging and dual sensing of vitamin B12 and hexavalent chromium. DYES AND PIGMENTS, 184 (108818). [PMID:] [10.1016/j.dyepig.2020.108818] |
27. Hailong Tian, Jing Zhang, Huiyuan Zhang, Yue Jiang, Aixin Song, Yuxia Luan. (2020) Low side-effect and heat-shock protein-inhibited chemo-phototherapy nanoplatform via co-assembling strategy of biotin-tailored IR780 and quercetin. CHEMICAL ENGINEERING JOURNAL, 382 (123043). [PMID:] [10.1016/j.cej.2019.123043] |
28. Zhang Yingyi, Li Liang, Wang Qi, Shen Mei, Han Weili, Yang Xuemei, Chen Lingyun, Ma Ande, Zhou Zhengzheng. (2019) Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (15): (3361-3372). [PMID:31119349] [10.1007/s00216-019-01810-5] |
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30. Caixia Yan, Na Liang, Qiang Li, Pengfei Yan, Shaoping Sun. (2019) Biotin and arginine modified hydroxypropyl-β-cyclodextrin nanoparticles as novel drug delivery systems for paclitaxel. CARBOHYDRATE POLYMERS, 216 (129). [PMID:31047049] [10.1016/j.carbpol.2019.04.024] |
31. Wang Danfeng, Liang Na, Kawashima Yoshiaki, Cui Fude, Yan Pengfei, Sun Shaoping. (2019) Biotin-modified bovine serum albumin nanoparticles as a potential drug delivery system for paclitaxel. JOURNAL OF MATERIALS SCIENCE, 54 (11): (8613-8626). [PMID:] [10.1007/s10853-019-03486-9] |
32. Mengna Liu, Bingjie Wang, Chunjing Guo, Xiaoya Hou, Ziting Cheng, Daquan Chen. (2019) Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy. DRUG DELIVERY, [PMID:31571501] [10.1080/10717544.2019.1669734] |
33. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang. (2018) Osthole inhibits triple negative breast cancer cells by suppressing STAT3. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-11). [PMID:30577812] [10.1186/s13046-018-0992-z] |
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36. Zihao Li, Chenggang Zhu, Zhihe Guo, Bowen Wang, Xiang Wu, Yiyan Fei. (2018) Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator. Micromachines, 9 (6): (274). [PMID:30424207] [10.3390/mi9060274] |
37. Wen Jingbai, Xiao Yanqiu, Liu Ting, Gao Qiuqiang, Bao Jie. (2018) Rich biotin content in lignocellulose biomass plays the key role in determining cellulosic glutamic acid accumulation by Corynebacterium glutamicum. Biotechnology for Biofuels, 11 (1): (1-12). [PMID:29760774] [10.1186/s13068-018-1132-x] |
38. Juan Chen, Zhongming Huang, Hongmin Meng, Lin Zhang, Danyang Ji, Juanzu Liu, Fei Yu, Lingbo Qu, Zhaohui Li. (2018) A facile fluorescence lateral flow biosensor for glutathione detection based on quantum dots-MnO2 nanocomposites. SENSORS AND ACTUATORS B-CHEMICAL, 260 (770). [PMID:] [10.1016/j.snb.2018.01.101] |
39. Zhipeng Zhang, Yun Wang, Shaohui Xu, Yanna Yu, Abid Hussain, Yuanyuan Shen, Shengrong Guo. (2017) Photothermal gold nanocages filled with temperature sensitive tetradecanol and encapsulated with glutathione responsive polycurcumin for controlled DOX delivery to maximize anti-MDR tumor effects. Journal of Materials Chemistry B, 5 (27): (5464-5472). [PMID:32264086] [10.1039/C7TB01253E] |
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37. Wen Jingbai, Xiao Yanqiu, Liu Ting, Gao Qiuqiang, Bao Jie. (2018) Rich biotin content in lignocellulose biomass plays the key role in determining cellulosic glutamic acid accumulation by Corynebacterium glutamicum. Biotechnology for Biofuels, 11 (1): (1-12). [PMID:29760774] [10.1186/s13068-018-1132-x] |
38. Juan Chen, Zhongming Huang, Hongmin Meng, Lin Zhang, Danyang Ji, Juanzu Liu, Fei Yu, Lingbo Qu, Zhaohui Li. (2018) A facile fluorescence lateral flow biosensor for glutathione detection based on quantum dots-MnO2 nanocomposites. SENSORS AND ACTUATORS B-CHEMICAL, 260 (770). [PMID:] [10.1016/j.snb.2018.01.101] |
39. Zhipeng Zhang, Yun Wang, Shaohui Xu, Yanna Yu, Abid Hussain, Yuanyuan Shen, Shengrong Guo. (2017) Photothermal gold nanocages filled with temperature sensitive tetradecanol and encapsulated with glutathione responsive polycurcumin for controlled DOX delivery to maximize anti-MDR tumor effects. Journal of Materials Chemistry B, 5 (27): (5464-5472). [PMID:32264086] [10.1039/C7TB01253E] |
40. Qingrui Yang, Shuting Pan, Yuan Zhao, Hao Zhang, Wei Pang, Xuexin Duan. (2017) Biomolecular stiffness detection based on positive frequency shift of CMOS compatible gigahertz solidly mounted resonators. BIOSENSORS & BIOELECTRONICS, 96 (206). [PMID:28499197] [10.1016/j.bios.2017.05.002] |
41. Mengying Luo, Wenwen Wang, Qinghua Zhao, Mufang Li, Yuanli Chen, Zhentan Lu, Ke Liu, Dong Wang. (2017) Chemiluminescence biosensor for hydrogen peroxide determination by immobilizing horseradish peroxidase onto PVA-co-PE nanofiber membrane. EUROPEAN POLYMER JOURNAL, 91 (307). [PMID:] [10.1016/j.eurpolymj.2017.04.018] |
42. Luyan Sun, Jiaxun Wan, Christian G. Schaefer, Zihao Zhang, Jing Tan, Jia Guo, Limin Wu, Changchun Wang. (2017) Specific On-site Assembly of Multifunctional Magnetic Nanocargos Based on Highly Efficient and Parallelized Bioconjugation: Toward Personalized Cancer Targeting Therapy. ACS Biomaterials Science & Engineering, 3 (3): (381–391). [PMID:33465935] [10.1021/acsbiomaterials.6b00773] |
43. Chenggang Zhu, Xiangdong Zhu, James P. Landry, Zhaomeng Cui, Quanfu Li, Yongjun Dang, Lan Mi, Fengyun Zheng, Yiyan Fei. (2016) Developing an Efficient and General Strategy for Immobilization of Small Molecules onto Microarrays Using Isocyanate Chemistry. SENSORS, 16 (3): (378). [PMID:26999137] [10.3390/s16030378] |
44. Guo Shengrong, Lv Li, Shen Yuanyuan, Hu Zhongliang, He Qianjun, Chen Xiaoyuan. (2016) A nanoparticulate pre-chemosensitizer for efficacious chemotherapy of multidrug resistant breast cancer. Scientific Reports, 6 (1): (1-11). [PMID:26875787] [10.1038/srep21459] |
45. Shengguo Lu, Fang Luo, Xujia Duan, Chen Jia, Yuwang Han, He Huang. (2014) Hybrid polydiacetylene/magnetite nanoparticles: Sensing for sodium cetyltrimethylammonium bromide and streptavidin. JOURNAL OF APPLIED POLYMER SCIENCE, 131 (16): [PMID:] [10.1002/app.40634] |
46. Jianyong Li, Xiaojun Kong, Xiwang Li, Yajun Yang, Jiyu Zhang. (2013) Genotoxic evaluation of aspirin eugenol ester using the Ames test and the mouse bone marrow micronucleus assay. FOOD AND CHEMICAL TOXICOLOGY, 62 (805). [PMID:24140966] [10.1016/j.fct.2013.10.010] |
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48. Donghua Liu, Fengxi Liu, Zhihong Liu, Lili Wang, Na Zhang. (2011) Tumor Specific Delivery and Therapy by Double-Targeted Nanostructured Lipid Carriers with Anti-VEGFR-2 Antibody. MOLECULAR PHARMACEUTICS, 8 (6): (2291–2301). [PMID:21923159] [10.1021/mp200402e] |
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