Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | D-cycloserine|cycloserine|68-41-7|Seromycin|orientomycin|Oxamycin|Cyclo-D-serine|Cyclorin|Cicloserina|Farmiserina|Miroseryn|Tisomycin|Wasserina|Closina|D-4-amino-3-isoxazolidinone|Cycloserinum|(+)-4-Amino-3-isoxazolidinone|alpha-Cycloserine|(R)-4-AMINOISO |
|---|---|
| Specifications & Purity | Moligand™, 10mM in Water |
| Biochemical and Physiological Mechanisms | Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference. Partial agonist at the glycine modulatory site of NMDA glutamater |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
Product Properties
| ALogP | -1.5 |
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Associated Targets
CYP1A2 Tchem Cytochrome P450 1A2 0 Activities
CYP2D6 Tclin Cytochrome P450 2D6 0 Activities
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CYP2C19 Tchem Cytochrome P450 2C19 0 Activities
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DRD1 Tclin D(1A) dopamine receptor 0 Activities
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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities
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ERVV-2 Tdark Endogenous retrovirus group V member 2 Env polyprotein 0 Activities
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ESR1 Tclin Estrogen receptor 0 Activities
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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities
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EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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CBX1 Tbio Chromobox protein homolog 1 0 Activities
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CYP2C9 Tchem Cytochrome P450 2C9 0 Activities
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RUNX1 Tbio Runt-related transcription factor 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SLC36A1 Tchem Proton-coupled amino acid transporter 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HRH3 Tclin Histamine H3 receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HDAC6 Tclin Histone deacetylase 6 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities
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TSHR Tclin Thyrotropin receptor 0 Activities
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PGR Tclin Progesterone receptor 0 Activities
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PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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RGS4 Tchem Regulator of G-protein signaling 4 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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DRD3 Tclin D(3) dopamine receptor 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities
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ACHE Tclin Acetylcholinesterase 0 Activities
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ABCB11 Tchem Bile salt export pump 0 Activities
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CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities
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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities
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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities
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AR Tclin Androgen receptor 0 Activities
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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities
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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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ADORA3 Tchem Adenosine receptor A3 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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TBXA2R Tclin Thromboxane A2 receptor 0 Activities
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F2 Tclin Prothrombin 0 Activities
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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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OPRM1 Tclin Mu-type opioid receptor 0 Activities
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GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities
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GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities
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Names and Identifiers
| IUPAC Name | (4R)-4-amino-1,2-oxazolidin-3-one |
|---|---|
| INCHI | InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1 |
| InChi Key | DYDCUQKUCUHJBH-UWTATZPHSA-N |
| Canonical SMILES | C1C(C(=O)NO1)N |
| Isomeric SMILES | C1[C@H](C(=O)NO1)N |
| WGK Germany | 2 |
| RTECS | NY2975000 |
| Alternate CAS | 68-41-7 |
| PubChem CID | 6234 |
| NSC Number | 756712 |
| MeSH Entry Terms | Cycloserine;R-4-Amino-3-isoxazolidinone;Seromycin |
| Molecular Weight | 102.09 |
| Beilstein | 80798 |
| Reaxy-Rn | 80798 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Sensitivity | heat & air sensitive |
|---|---|
| Specific Rotation[α] | +110 to +130 deg(C=1, H2O) |
| Melt Point(°C) | 147°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H332:Harmful if inhaled |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 2 |
| RTECS | NY2975000 |
| Reaxy-Rn | 80798 |
| Merck Index | 2751 |