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D,L-Venlafaxine - 10mM in DMSO, high purity , CAS No.93413-69-5
Basic Description Synonyms venlafaxine|93413-69-5|D,L-Venlafaxine|Elafax|Venlafaxina|Venlafaxinum|Efectin|1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol|velafax|Effexor|Venlafaxinum [INN-Latin]|Venlafexine|Kanghong|Trevilor|Venlafaxina [INN-Spanish]|Venlor|1-[2-(dimethy Specifications & Purity Moligand™, 10mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description D,L-Venlafaxine is an isomer of Venlafaxine . Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake.|In vitro|studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.
Product Properties pKa pKₐ: 9.27 (Predicted) Ki Data Norepinephrine transporter: Ki= 138 nM (rat); Serotonin transporter: Ki= 52 nM (rat); Dopamine transporter: Ki= 360 nM (rat)
Names and Identifiers IUPAC Name 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol INCHI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 InChi Key PNVNVHUZROJLTJ-UHFFFAOYSA-N Canonical SMILES CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O Isomeric SMILES CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O RTECS GV8872620 PubChem CID 5656 Molecular Weight 277.4 Beilstein 4234848
Chemical and Physical Properties Refractive Index n20D1.54 (Predicted) Boil Point(°C) 397.58° C at 760 mmHg (Predicted) Melt Point(°C) 72-74° C (lit.)
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS07 Signal Danger Hazard Statements H319: Causes serious eye irritation
H411: Toxic to aquatic life with long lasting effects
H302: Harmful if swallowed
H360: May damage fertility or the unborn child
H362: May cause harm to breast-fed children
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P263: Avoid contact during pregnancy/while nursing.
P203: Obtain, read and follow all safety instructions before use.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P337+P317: If eye irritation persists: Get medical help.
RTECS GV8872620
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