D-Lactic Acid - >90.0%(T), high purity , CAS No.10326-41-7, Agonist of HCA 1 receptor

Item Number
S161106
Grouped product items
SKUSizeAvailabilityPrice Qty
S161106-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$70.90
S161106-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$210.90
S161106-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$759.90
S161106-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$3,416.90
View related series
HCA1 receptor Agonist

Basic Description

Synonyms(D)-(-)-Lactic acid | (R)-lactate | (R)-2-Hydroxypropionate | D-2-Hydroxypropionic acid | D-(-)-Lactate | D-LACTIC ACID [WHO-DD] | AS-19478 | HY-111095 | (R)-2-Hydroxypropionic acid(R)-2-Hydroxypropionic acid | (R)-alpha-Hydroxypropionate | D-Lactic acid
Specifications & PurityMoligand™, ≥90%(T)
Biochemical and Physiological MechanismsIn animals, lactic acid is a metabolic compound produced by proliferating cells and during anaerobic conditions such as strenuous exercise. Lactic acid can be oxidized back to pyruvate or converted to glucose via gluconeogenesis. Lactic acid is preferenti
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of HCA 1 receptor
Product Description

Lactic acid is used as a reagent in organic synthesis (in the manufacture of adhesives). It is used in the leather, textile, and tanning industries. It may be used as a plasticizer, a catalyst, or an acidifying agent. Lactic acid has even been used as a flavoring agent in the manufacture of tobacco products.

Associated Targets(Human)

HCAR1 Tchem Hydroxycarboxylic acid receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (580 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A3 Tchem Monocarboxylate transporter 4 (196 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A7 Tchem Monocarboxylate transporter 2 (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A10 SLC16A10 protein (28 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Slco2a1 Solute carrier organic anion transporter family member 2A1 (47 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc16a10 Monocarboxylate transporter 10 (73 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R)-2-hydroxypropanoic acid
INCHI InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1
InChi Key JVTAAEKCZFNVCJ-UWTATZPHSA-N
Canonical SMILES CC(C(=O)O)O
Isomeric SMILES C[C@H](C(=O)O)O
PubChem CID 61503
Molecular Weight 90.08
Reaxy-Rn 1720252

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
F2404014Certificate of AnalysisJul 05, 2023 S161106
G2326283Certificate of AnalysisJul 05, 2023 S161106
G2326562Certificate of AnalysisJul 05, 2023 S161106
G2326585Certificate of AnalysisJul 05, 2023 S161106
G2326589Certificate of AnalysisJul 05, 2023 S161106
G2326594Certificate of AnalysisJul 05, 2023 S161106
F2307328Certificate of AnalysisJun 24, 2022 S161106
G2213380Certificate of AnalysisJun 24, 2022 S161106
G2213382Certificate of AnalysisJun 24, 2022 S161106
G2213383Certificate of AnalysisJun 24, 2022 S161106

Chemical and Physical Properties

SolubilitySoluble in water (50mg/ml)
Sensitivityheat sensitive
Refractive Index1.43
Specific Rotation[α]13° (C=2.5,1.5mol/L NaOH)
Flash Point(°C)110 °C

Safety and Hazards(GHS)

Pictogram(s) GHS05,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H318:Causes serious eye damage

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P264:Wash hands [and …] thoroughly after handling.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P317:Get emergency medical help.

P332+P317:If skin irritation occurs: Get medical help.

Reaxy-Rn 1720252
Merck Index 5335

Related Documents

Citations of This Product

1. Rongxiu Qin, Haiyan Chen, Rusi Wen, Guiqing Li, Zhonglei Meng.  (2023)  Effect of Boric Acid on the Ionization Equilibrium of α-Hydroxy Carboxylic Acids and the Study of Its Applications.  MOLECULES,  28  (12): (4723).  [PMID:37375278] [10.3390/molecules28124723]
2. Xiao Zheng, Ying Liu, Yiqiong Liu, Tingting Zhang, Yuge Zhao, Jie Zang, Yan Yang, Ruiqing He, Gaowei Chong, Shuangrong Ruan, Dailin Xu, Yongyong Li, Haiqing Dong.  (2022)  Dual Closed-Loop of Catalyzed Lactate Depletion and Immune Response to Potentiate Photothermal Immunotherapy.  ACS Applied Materials & Interfaces,  14  (20): (23260–23276).  [PMID:35578899] [10.1021/acsami.2c07254]
3. Jie Sun, Yaping Wang, Zhenguo Gao, Junbo Gong, Weiwei Tang.  (2022)  Additive-assisted preferential crystallization of racemic component: A case of norvaline.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,  110  (206).  [PMID:] [10.1016/j.jiec.2022.02.054]
4. Jianjian Zhao, Aiyou Hao, Pengyao Xing.  (2021)  Enhancing Optical Activities of Benzimidazole Derivatives through Coassembly for High-Efficiency Synthesis of Chiroptical Nanomaterials and Accurate ee % Detection of Natural Acids.  ACS Applied Materials & Interfaces,  13  (5): (6830–6843).  [PMID:33502861] [10.1021/acsami.0c20735]
5. Kaiyang Ma, Xiao Ding, Qiqi Song, Zhitao Han, Hang Yao, Jianhua Ding, Gang Hu.  (2020)  Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes.  NEUROPHARMACOLOGY,  171  (108084).  [PMID:32294462] [10.1016/j.neuropharm.2020.108084]
6. Shengli Mi, Jingjing Xia, Yuanyuan Xu, Zhichang Du, Wei Sun.  (2019)  An integrated microchannel biosensor platform to analyse low density lactate metabolism in HepG2 cells in vitro.  RSC Advances,  (16): (9006-9013).  [PMID:35517697] [10.1039/C9RA00694J]
7. Ai-Ling Hu, Yin-Huan Liu, Hao-Hua Deng, Guo-Lin Hong, Ai-Lin Liu, Xin-Hua Lin, Xing-Hua Xia, Wei Chen.  (2014)  Fluorescent hydrogen peroxide sensor based on cupric oxide nanoparticles and its application for glucose and l-lactate detection.  BIOSENSORS & BIOELECTRONICS,  61  (374).  [PMID:24912038] [10.1016/j.bios.2014.05.048]

References

1. Rongxiu Qin, Haiyan Chen, Rusi Wen, Guiqing Li, Zhonglei Meng.  (2023)  Effect of Boric Acid on the Ionization Equilibrium of α-Hydroxy Carboxylic Acids and the Study of Its Applications.  MOLECULES,  28  (12): (4723).  [PMID:37375278] [10.3390/molecules28124723]
2. Xiao Zheng, Ying Liu, Yiqiong Liu, Tingting Zhang, Yuge Zhao, Jie Zang, Yan Yang, Ruiqing He, Gaowei Chong, Shuangrong Ruan, Dailin Xu, Yongyong Li, Haiqing Dong.  (2022)  Dual Closed-Loop of Catalyzed Lactate Depletion and Immune Response to Potentiate Photothermal Immunotherapy.  ACS Applied Materials & Interfaces,  14  (20): (23260–23276).  [PMID:35578899] [10.1021/acsami.2c07254]
3. Jie Sun, Yaping Wang, Zhenguo Gao, Junbo Gong, Weiwei Tang.  (2022)  Additive-assisted preferential crystallization of racemic component: A case of norvaline.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,  110  (206).  [PMID:] [10.1016/j.jiec.2022.02.054]
4. Jianjian Zhao, Aiyou Hao, Pengyao Xing.  (2021)  Enhancing Optical Activities of Benzimidazole Derivatives through Coassembly for High-Efficiency Synthesis of Chiroptical Nanomaterials and Accurate ee % Detection of Natural Acids.  ACS Applied Materials & Interfaces,  13  (5): (6830–6843).  [PMID:33502861] [10.1021/acsami.0c20735]
5. Kaiyang Ma, Xiao Ding, Qiqi Song, Zhitao Han, Hang Yao, Jianhua Ding, Gang Hu.  (2020)  Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes.  NEUROPHARMACOLOGY,  171  (108084).  [PMID:32294462] [10.1016/j.neuropharm.2020.108084]
6. Shengli Mi, Jingjing Xia, Yuanyuan Xu, Zhichang Du, Wei Sun.  (2019)  An integrated microchannel biosensor platform to analyse low density lactate metabolism in HepG2 cells in vitro.  RSC Advances,  (16): (9006-9013).  [PMID:35517697] [10.1039/C9RA00694J]
7. Ai-Ling Hu, Yin-Huan Liu, Hao-Hua Deng, Guo-Lin Hong, Ai-Lin Liu, Xin-Hua Lin, Xing-Hua Xia, Wei Chen.  (2014)  Fluorescent hydrogen peroxide sensor based on cupric oxide nanoparticles and its application for glucose and l-lactate detection.  BIOSENSORS & BIOELECTRONICS,  61  (374).  [PMID:24912038] [10.1016/j.bios.2014.05.048]

Solution Calculators