D(-)-Norgestrel - ≥99%, high purity , Progesterone receptor agonist, CAS No.797-63-7, Progesterone receptor agonist

Item Number
D129210
Grouped product items
SKUSizeAvailabilityPrice Qty
D129210-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$57.90
D129210-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$260.90
D129210-1g
1g
In stock
$938.90
D129210-5g
5g
In stock
$4,224.90

Synthetic progesterone analog

Basic Description

SynonymsLevonorgestrelum | (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one | alpha-Norgestrel | FH-122A | Monovar | NORGE
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsSynthetic progesterone analog; binds to the progesterone receptor (relative binding affinities are < 0.02, 7.5, 17, 58 and 323 % for estrogen receptors, glucocorticoid receptors, mineralocorticoid receptors, androgen receptors and progesterone receptors r
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionProgesterone receptor agonist

Associated Targets(Human)

PGR Tclin Progesterone receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
INCHI InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
InChi Key WWYNJERNGUHSAO-XUDSTZEESA-N
Canonical SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Isomeric SMILES CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
WGK Germany 3
RTECS JF8259000
PubChem CID 13109
Molecular Weight 312.45

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
D1909143Certificate of AnalysisSep 04, 2024 D129210
F2229355Certificate of AnalysisMay 09, 2024 D129210
F2229346Certificate of AnalysisApr 15, 2024 D129210

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 31.25, Max Conc. mM: 100
Sensitivityheat sensitive
Specific Rotation[α][α]D:-34~-31° (C=1,CHCl3)
Melt Point(°C)236℃

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS09
Signal Danger
Hazard Statements

H351:Suspected of causing cancer

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

H360:May damage fertility or the unborn child

H362:May cause harm to breast-fed children

Precautionary Statements

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P263:Avoid contact during pregnancy/while nursing.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

WGK Germany 3
RTECS JF8259000

Related Documents

Citations of This Product

1. Qiuye Jin, Qiong Duan, Dingyu Ji, Jie Chang, Zhaomin Tang.  (2023)  Reaction mechanism, degradation pathway and toxicity assessment of NH4+ enhanced potassium ferrate removal of levofloxacin.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  180  (16): (725).  [PMID:16698035] [10.1016/j.psep.2023.10.037]
2. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li.  (2023)  Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin.  ACS Applied Nano Materials,  (18): (17040–17052).  [PMID:11485546] [10.1021/acsanm.3c03162]
3. Tingting Li, Guoqiang Guo, Haoming Xing, Siyuan Tang, Houwen Hu, Linfan Wang, Xiaoqing Qian, Da Chen.  (2023)  Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food.  FOOD CHEMISTRY,  429  (136947).  [PMID:37499515] [10.1016/j.foodchem.2023.136947]
4. Donghui Wang, Yu-e Shi, Zhen Zhang, Song Shen, Zhenguang Wang.  (2023)  Modulating Emission of Organic Emitters from Fluorescence to Red Afterglow through Boric Acid-Assisted Energy Transfer.  Journal of Physical Chemistry C,  127  (1): (682–688).  [PMID:] [10.1021/acs.jpcc.2c07138]
5. Anhua Jiang, Xinwen Huang, Geshan Zhang, Wanquan Yang.  (2022)  A Study of the Degradation of LEV by Transparent PVA/NCD-TiO2 Nanocomposite Films with Enhanced Visible-Light Photocatalytic Activity.  Catalysts,  12  (11): (1336).  [PMID:] [10.3390/catal12111336]
6. Qinyue Wu, Yan Zhang, He Liu, Hongbo Liu, Jia Tao, Min-Hua Cui, Zhiyong Zheng, Donghui Wen, Xinmin Zhan.  (2022)  FexN produced in pharmaceutical sludge biochar by endogenous Fe and exogenous N doping to enhance peroxymonosulfate activation for levofloxacin degradation.  WATER RESEARCH,  224  (119022).  [PMID:36099758] [10.1016/j.watres.2022.119022]
7. Xiang-Yu Zheng, Hai-Chen Zhang, Yu-Dan Lv, Feng-Yan Jin, Xiu-Juan Wu, Jie Zhu, Yang Ruan.  (2022)  Levetiracetam alleviates cognitive decline in Alzheimer's disease animal model by ameliorating the dysfunction of the neuronal network..  Frontiers in Aging Neuroscience,  14  (888784-888784).  [PMID:36092803] [10.3389/fnagi.2022.888784]
8. Yichen Zhang, Shugui Hua, Xiaoqin Sun, Zhuoyue Liu, Yuan Dang, Liang Zhang, Yuanzhen Zhou.  (2021)  A novel electrochemical cathode based on sea urchin-like NiO/Co3O4 composite inducing efficient Fenton-like process for levofloxacin degradation.  APPLIED CATALYSIS A-GENERAL,  628  (118403).  [PMID:] [10.1016/j.apcata.2021.118403]
9. Yafeng Jin, Guangri Xu, Xiaobo Li, Jingjing Ma, Li Yang, Yuanchao Li, Huan Zhang, Zhen Zhang, Donghao Yao, Donghao Li.  (2021)  Fast cathodic reduction electrodeposition of a binder-free cobalt-doped Ni-MOF film for directly sensing of levofloxacin.  JOURNAL OF ALLOYS AND COMPOUNDS,  851  (156823).  [PMID:] [10.1016/j.jallcom.2020.156823]
10. Huikai Shao, Haibo Zhou, Tingting Zhang, Xianglong Zhao, Zhengjin Jiang, Qiqin Wang.  (2019)  Preparation of molecularly imprinted hybrid monoliths for the selective detection of fluoroquinolones in infant formula powders.  JOURNAL OF CHROMATOGRAPHY A,  1588  (33).  [PMID:30587346] [10.1016/j.chroma.2018.12.038]
11. Liu Chaoqiao, Xie Dong, Liu Peng, Xie Shilei, Wang Shoushan, Cheng Faliang, Zhang Min, Wang Lishi.  (2019)  Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film.  MICROCHIMICA ACTA,  186  (1): (1-10).  [PMID:30554349] [10.1007/s00604-018-3146-2]

References

1. Qiuye Jin, Qiong Duan, Dingyu Ji, Jie Chang, Zhaomin Tang.  (2023)  Reaction mechanism, degradation pathway and toxicity assessment of NH4+ enhanced potassium ferrate removal of levofloxacin.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  180  (16): (725).  [PMID:16698035] [10.1016/j.psep.2023.10.037]
2. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li.  (2023)  Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin.  ACS Applied Nano Materials,  (18): (17040–17052).  [PMID:11485546] [10.1021/acsanm.3c03162]
3. Tingting Li, Guoqiang Guo, Haoming Xing, Siyuan Tang, Houwen Hu, Linfan Wang, Xiaoqing Qian, Da Chen.  (2023)  Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food.  FOOD CHEMISTRY,  429  (136947).  [PMID:37499515] [10.1016/j.foodchem.2023.136947]
4. Donghui Wang, Yu-e Shi, Zhen Zhang, Song Shen, Zhenguang Wang.  (2023)  Modulating Emission of Organic Emitters from Fluorescence to Red Afterglow through Boric Acid-Assisted Energy Transfer.  Journal of Physical Chemistry C,  127  (1): (682–688).  [PMID:] [10.1021/acs.jpcc.2c07138]
5. Anhua Jiang, Xinwen Huang, Geshan Zhang, Wanquan Yang.  (2022)  A Study of the Degradation of LEV by Transparent PVA/NCD-TiO2 Nanocomposite Films with Enhanced Visible-Light Photocatalytic Activity.  Catalysts,  12  (11): (1336).  [PMID:] [10.3390/catal12111336]
6. Qinyue Wu, Yan Zhang, He Liu, Hongbo Liu, Jia Tao, Min-Hua Cui, Zhiyong Zheng, Donghui Wen, Xinmin Zhan.  (2022)  FexN produced in pharmaceutical sludge biochar by endogenous Fe and exogenous N doping to enhance peroxymonosulfate activation for levofloxacin degradation.  WATER RESEARCH,  224  (119022).  [PMID:36099758] [10.1016/j.watres.2022.119022]
7. Xiang-Yu Zheng, Hai-Chen Zhang, Yu-Dan Lv, Feng-Yan Jin, Xiu-Juan Wu, Jie Zhu, Yang Ruan.  (2022)  Levetiracetam alleviates cognitive decline in Alzheimer's disease animal model by ameliorating the dysfunction of the neuronal network..  Frontiers in Aging Neuroscience,  14  (888784-888784).  [PMID:36092803] [10.3389/fnagi.2022.888784]
8. Yichen Zhang, Shugui Hua, Xiaoqin Sun, Zhuoyue Liu, Yuan Dang, Liang Zhang, Yuanzhen Zhou.  (2021)  A novel electrochemical cathode based on sea urchin-like NiO/Co3O4 composite inducing efficient Fenton-like process for levofloxacin degradation.  APPLIED CATALYSIS A-GENERAL,  628  (118403).  [PMID:] [10.1016/j.apcata.2021.118403]
9. Yafeng Jin, Guangri Xu, Xiaobo Li, Jingjing Ma, Li Yang, Yuanchao Li, Huan Zhang, Zhen Zhang, Donghao Yao, Donghao Li.  (2021)  Fast cathodic reduction electrodeposition of a binder-free cobalt-doped Ni-MOF film for directly sensing of levofloxacin.  JOURNAL OF ALLOYS AND COMPOUNDS,  851  (156823).  [PMID:] [10.1016/j.jallcom.2020.156823]
10. Huikai Shao, Haibo Zhou, Tingting Zhang, Xianglong Zhao, Zhengjin Jiang, Qiqin Wang.  (2019)  Preparation of molecularly imprinted hybrid monoliths for the selective detection of fluoroquinolones in infant formula powders.  JOURNAL OF CHROMATOGRAPHY A,  1588  (33).  [PMID:30587346] [10.1016/j.chroma.2018.12.038]
11. Liu Chaoqiao, Xie Dong, Liu Peng, Xie Shilei, Wang Shoushan, Cheng Faliang, Zhang Min, Wang Lishi.  (2019)  Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film.  MICROCHIMICA ACTA,  186  (1): (1-10).  [PMID:30554349] [10.1007/s00604-018-3146-2]

Solution Calculators