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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | D-phenylalanine | 673-06-3 | H-D-Phe-OH | (2R)-2-amino-3-phenylpropanoic acid | Phenylalanine D-form | Sabiden | D-Phe | (R)-2-AMINO-3-PHENYLPROPANOIC ACID | Alanine, phenyl-, D- | NCI-C60195 | Phenylalanine,d- | D-alpha-Amino-beta-phenylpropionic acid | D-(+)-Phenylalanine | (R)- |
|---|---|
| Specifications & Purity | Moligand™, 2mM in Water |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | It is an essential amino acid with anti-depressant and analgesic activities. pharmaceutical intermediates, mainly used to treat, prevent osteoporosis, cardiovascular, diabetes, arterioscleros. |
Associated Targets(Human)
HCAR3 Tchem Hydroxycarboxylic acid receptor 3 (1 Activities)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA3 Tclin Carbonic anhydrase III (753 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA6 Tclin Carbonic anhydrase VI (993 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA1 Tclin Carbonic anhydrase I (13240 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA5B Tclin Carbonic anhydrase VB (957 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA5A Tclin Carbonic anhydrase VA (1168 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA14 Tclin Carbonic anhydrase XIV (1305 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA12 Tclin Carbonic anhydrase XII (6231 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CA9 Tclin Carbonic anhydrase IX (8255 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SLC16A10 SLC16A10 protein (28 Activities)
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Associated Targets(non-human)
Ca7 Carbonic anhydrase VII (3 Activities)
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Ca13 Carbonic anhydrase XIII (322 Activities)
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CA4 Carbonic anhydrase IV (1713 Activities)
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Hdac6 Histone deacetylase 6 (222 Activities)
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Carbonic anhydrase (69 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Staphylococcus aureus (210822 Activities)
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Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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rep Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Ca15 Carbonic anhydrase 15 (173 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CAN2 Carbonic anhydrase 2 (140 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Slc16a10 Monocarboxylate transporter 10 (73 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Carbonic anhydrase-like protein, putative (25 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SARS-CoV-2 (38078 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Names and Identifiers
| IUPAC Name | (2R)-2-amino-3-phenylpropanoic acid |
|---|---|
| INCHI | InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1 |
| InChi Key | COLNVLDHVKWLRT-MRVPVSSYSA-N |
| Canonical SMILES | C1=CC=C(C=C1)CC(C(=O)O)N |
| Isomeric SMILES | C1=CC=C(C=C1)C[C@H](C(=O)O)N |
| WGK Germany | 3 |
| RTECS | AY7533000 |
| PubChem CID | 71567 |
| Molecular Weight | 165.19 |
| Beilstein | 2804068 |
| Reaxy-Rn | 2804068 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Specific Rotation[α] | 34 ° (C=2, H2O) |
|---|---|
| Melt Point(°C) | 273-276°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | AY7533000 |
| Reaxy-Rn | 2804068 |
| Merck Index | 7271 |
Related Documents
Citations of This Product
| 1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652] |
| 2. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai. (2023) Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point. Advanced Science, (2308362). [PMID:38072636] |
| 3. Jianrong Wang, Sha Han, Hongfang Zhao, Hongxia Li, Xiaohui Niu, Yi Wang, Kunjie Wang. (2023) Electrochemical enantioselective recognition by defined chiral linkers in polysaccharides modified with carbon quantum dots. ELECTROANALYSIS, (6): (e202300301). [PMID:9169421] |
| 4. Li Yuchen, Xu Guangfu, Chen Jiaquan, Yu Tao, Miao Pandeng, Du Yingxiang. (2023) One-step synthesis of chiral molecularly imprinted polymer TiO2 nanoparticles for enantioseparation of phenylalanine in coated capillary electrochromatography. MICROCHIMICA ACTA, 190 (7): (1-11). [PMID:37391671] |
| 5. Niu Xiaohui, Zhao Rui, Yan Simeng, Li Hongxia, Yang Jing, Cao Kunjie, Liu Xiaoyu, Wang Kunjie. (2023) Chiral MOFs encapsulated by polymers with poly-metallic coordination as chiral biosensors. MICROCHIMICA ACTA, 190 (6): (1-12). [PMID:37208529] |
| 6. Hou Huipeng, Tang Shanshan, Wang Wei, Liu Miao, Liang Axin, Xie Bingteng, Yi Yue, Luo Aiqin. (2023) Electrochemical Chiral Recognizing Tryptophan Enantiomers Based on Chiral Metal-Organic Framework D-MOF. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 39 (6): (976-984). [PMID:] |
| 7. Qian Ye, Jin Li, Yinyin Huang, Hanbin Wu, Yilin Li, Bin Yan. (2023) Preparation of a cyclodextrin metal-organic framework (CD-MOF) membrane for chiral separation. Journal of Environmental Chemical Engineering, 11 (109250). [PMID:] |
| 8. Jinglei Liu, Tianfei Chu, Mengmeng Cheng, Yan Su, Guizheng Zou, Shifeng Hou. (2023) Bovine serum albumin functional graphene oxide membrane for effective chiral separation. JOURNAL OF MEMBRANE SCIENCE, 668 (121198). [PMID:] |
| 9. Yiyi Liu, Fangling Wu, Jiabin Wang, Ling Pu, Chuan-Fan Ding. (2022) Simultaneous chirality separation of amino acids and their derivative by natamycin based on mobility measurements. ANALYTICA CHIMICA ACTA, 1227 (340298). [PMID:36089312] |
| 10. Hai-Bin Qin, Jun-Ping Zhou, Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng. (2022) Combing with redox regulation via quorum-sensing system and fermentation strategies for improving D-pantothenic acid production. PROCESS BIOCHEMISTRY, 121 (681). [PMID:] |
| 11. Wancheng Qin, Peng Zhou, Xinyu Xu, Chuanwei Huang, Gopalan Srinivasan, Yajun Qi, Tianjin Zhang. (2022) High-Performance Piezoelectric Nanogenerator Based on Low-Entropy Structured Nanofibers for a Multi-Mode Energy Harvesting and Self-Powered Ultraviolet Photodetector. ACS Applied Electronic Materials, 4 (6): (2970–2978). [PMID:] |
| 12. Yi Wu, Keren Lu, Fubin Pei, Yanghao Yan, Shasha Feng, Qingli Hao, Mingzhu Xia, Wu Lei. (2022) Construction of g-C3N4/Au/NH2-UiO-66 Z-scheme heterojunction for label-free photoelectrochemical recognition of D-penicillamine. TALANTA, 248 (123617). [PMID:35687949] |
| 13. Hongxia Li, Letong Wang, Simeng Yan, Jinliang Chen, Mengmeng Zhang, Rui Zhao, Xiaohui Niu, Kunjie Wang. (2022) Fusiform-like metal-organic framework for enantioselective discrimination of tryptophan enantiomers. ELECTROCHIMICA ACTA, 419 (140409). [PMID:] |
| 14. Xiaohui Niu, Simeng Yan, Letong Wang, Jinliang Chen, Rui Zhao, Hongxia Li, Jian Liu, Kunjie Wang. (2022) Induction of chiral polymers from metal-organic framework for stereoselective recognition. ANALYTICA CHIMICA ACTA, 1196 (339546). [PMID:35151404] |
| 15. Xiaohui Niu, Simeng Yan, Jinliang Chen, Hongxia Li, Kunjie Wang. (2022) Enantioselective recognition of L/D-amino acids in the chiral nanochannels of a metal-organic framework. ELECTROCHIMICA ACTA, 405 (139809). [PMID:] |
| 16. Xin-hui Zhou, Qing Liu, Hai-shui Wang. (2022) Chiral resolution of DL-glutamic acid by a chiral additive. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 97 (5): (1240-1246). [PMID:] |
| 17. Xiaodan Wang, Fangping Yang, Huawei Yang, Xu Zhang, Haoyu Tang, Shifang Luan. (2022) Preparation of antibacterial polypeptides with different topologies and their antibacterial properties. Biomaterials Science, 10 (3): (834-845). [PMID:35005755] |
| 18. Chen Qi,Wenke Yang,Fuyan He,Jinshui Yao. (2020-09-13) The Thermal Properties and Degradability of Chiral Polyester-Imides Based on Several l/d-Amino Acids.. Polymers, 12 ((9)): [PMID:32916788] |
References
| 1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652] |
| 2. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai. (2023) Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point. Advanced Science, (2308362). [PMID:38072636] |
| 3. Jianrong Wang, Sha Han, Hongfang Zhao, Hongxia Li, Xiaohui Niu, Yi Wang, Kunjie Wang. (2023) Electrochemical enantioselective recognition by defined chiral linkers in polysaccharides modified with carbon quantum dots. ELECTROANALYSIS, (6): (e202300301). [PMID:9169421] |
| 4. Li Yuchen, Xu Guangfu, Chen Jiaquan, Yu Tao, Miao Pandeng, Du Yingxiang. (2023) One-step synthesis of chiral molecularly imprinted polymer TiO2 nanoparticles for enantioseparation of phenylalanine in coated capillary electrochromatography. MICROCHIMICA ACTA, 190 (7): (1-11). [PMID:37391671] |
| 5. Niu Xiaohui, Zhao Rui, Yan Simeng, Li Hongxia, Yang Jing, Cao Kunjie, Liu Xiaoyu, Wang Kunjie. (2023) Chiral MOFs encapsulated by polymers with poly-metallic coordination as chiral biosensors. MICROCHIMICA ACTA, 190 (6): (1-12). [PMID:37208529] |
| 6. Hou Huipeng, Tang Shanshan, Wang Wei, Liu Miao, Liang Axin, Xie Bingteng, Yi Yue, Luo Aiqin. (2023) Electrochemical Chiral Recognizing Tryptophan Enantiomers Based on Chiral Metal-Organic Framework D-MOF. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 39 (6): (976-984). [PMID:] |
| 7. Qian Ye, Jin Li, Yinyin Huang, Hanbin Wu, Yilin Li, Bin Yan. (2023) Preparation of a cyclodextrin metal-organic framework (CD-MOF) membrane for chiral separation. Journal of Environmental Chemical Engineering, 11 (109250). [PMID:] |
| 8. Jinglei Liu, Tianfei Chu, Mengmeng Cheng, Yan Su, Guizheng Zou, Shifeng Hou. (2023) Bovine serum albumin functional graphene oxide membrane for effective chiral separation. JOURNAL OF MEMBRANE SCIENCE, 668 (121198). [PMID:] |
| 9. Yiyi Liu, Fangling Wu, Jiabin Wang, Ling Pu, Chuan-Fan Ding. (2022) Simultaneous chirality separation of amino acids and their derivative by natamycin based on mobility measurements. ANALYTICA CHIMICA ACTA, 1227 (340298). [PMID:36089312] |
| 10. Hai-Bin Qin, Jun-Ping Zhou, Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng. (2022) Combing with redox regulation via quorum-sensing system and fermentation strategies for improving D-pantothenic acid production. PROCESS BIOCHEMISTRY, 121 (681). [PMID:] |
| 11. Wancheng Qin, Peng Zhou, Xinyu Xu, Chuanwei Huang, Gopalan Srinivasan, Yajun Qi, Tianjin Zhang. (2022) High-Performance Piezoelectric Nanogenerator Based on Low-Entropy Structured Nanofibers for a Multi-Mode Energy Harvesting and Self-Powered Ultraviolet Photodetector. ACS Applied Electronic Materials, 4 (6): (2970–2978). [PMID:] |
| 12. Yi Wu, Keren Lu, Fubin Pei, Yanghao Yan, Shasha Feng, Qingli Hao, Mingzhu Xia, Wu Lei. (2022) Construction of g-C3N4/Au/NH2-UiO-66 Z-scheme heterojunction for label-free photoelectrochemical recognition of D-penicillamine. TALANTA, 248 (123617). [PMID:35687949] |
| 13. Hongxia Li, Letong Wang, Simeng Yan, Jinliang Chen, Mengmeng Zhang, Rui Zhao, Xiaohui Niu, Kunjie Wang. (2022) Fusiform-like metal-organic framework for enantioselective discrimination of tryptophan enantiomers. ELECTROCHIMICA ACTA, 419 (140409). [PMID:] |
| 14. Xiaohui Niu, Simeng Yan, Letong Wang, Jinliang Chen, Rui Zhao, Hongxia Li, Jian Liu, Kunjie Wang. (2022) Induction of chiral polymers from metal-organic framework for stereoselective recognition. ANALYTICA CHIMICA ACTA, 1196 (339546). [PMID:35151404] |
| 15. Xiaohui Niu, Simeng Yan, Jinliang Chen, Hongxia Li, Kunjie Wang. (2022) Enantioselective recognition of L/D-amino acids in the chiral nanochannels of a metal-organic framework. ELECTROCHIMICA ACTA, 405 (139809). [PMID:] |
| 16. Xin-hui Zhou, Qing Liu, Hai-shui Wang. (2022) Chiral resolution of DL-glutamic acid by a chiral additive. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 97 (5): (1240-1246). [PMID:] |
| 17. Xiaodan Wang, Fangping Yang, Huawei Yang, Xu Zhang, Haoyu Tang, Shifang Luan. (2022) Preparation of antibacterial polypeptides with different topologies and their antibacterial properties. Biomaterials Science, 10 (3): (834-845). [PMID:35005755] |
| 18. Chen Qi,Wenke Yang,Fuyan He,Jinshui Yao. (2020-09-13) The Thermal Properties and Degradability of Chiral Polyester-Imides Based on Several l/d-Amino Acids.. Polymers, 12 ((9)): [PMID:32916788] |