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D-Phenylalanine - 98%, high purity , CAS No.673-06-3, Agonist of HCA 3 receptor

  • Moligand™
  • ≥98%
Item Number
P109094
Grouped product items
SKUSizeAvailabilityPrice Qty
P109094-5g
5g
In stock
$17.90
P109094-25g
25g
In stock
$47.90
P109094-100g
100g
In stock
$171.90
P109094-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$769.90
View related series
HCA3 receptor Agonist

Basic Description

SynonymsD-phenylalanine|673-06-3|H-D-Phe-OH|(2R)-2-amino-3-phenylpropanoic acid|Phenylalanine D-form|Sabiden|D-Phe|(R)-2-AMINO-3-PHENYLPROPANOIC ACID|Alanine, phenyl-, D-|NCI-C60195|Phenylalanine,d-|D-alpha-Amino-beta-phenylpropionic acid|D-(+)-Phenylalanine|(R)-
Specifications & PurityMoligand™, ≥98%
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of HCA 3 receptor
Product Description

It is an essential amino acid with anti-depressant and analgesic activities. pharmaceutical intermediates, mainly used to treat, prevent osteoporosis, cardiovascular, diabetes, arterioscleros.

Associated Targets

CA5A Tclin Carbonic anhydrase 5A, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC16A10 Tbio Monocarboxylate transporter 10 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC7A5 Tchem Large neutral amino acids transporter small subunit 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA5B Tclin Carbonic anhydrase 5B, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA6 Tclin Carbonic anhydrase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA13 Tclin Carbonic anhydrase 13 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA1 Tclin Carbonic anhydrase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA3 Tclin Carbonic anhydrase 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA4 Tclin Carbonic anhydrase 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA12 Tclin Carbonic anhydrase 12 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA14 Tclin Carbonic anhydrase 14 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA9 Tclin Carbonic anhydrase 9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA7 Tclin Carbonic anhydrase 7 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HCAR3 Tchem Hydroxycarboxylic acid receptor 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488184663
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184663
IUPAC Name (2R)-2-amino-3-phenylpropanoic acid
INCHI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1
InChi Key COLNVLDHVKWLRT-MRVPVSSYSA-N
Canonical SMILES C1=CC=C(C=C1)CC(C(=O)O)N
Isomeric SMILES C1=CC=C(C=C1)C[C@H](C(=O)O)N
WGK Germany 3
RTECS AY7533000
PubChem CID 71567
Molecular Weight 165.19
Beilstein 2804068
Reaxy-Rn 2804068

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

18 results found

Lot NumberCertificate TypeDateItem
B2320461Certificate of AnalysisJan 09, 2023 P109094
B2320468Certificate of AnalysisJan 09, 2023 P109094
B2320474Certificate of AnalysisJan 09, 2023 P109094
B2320551Certificate of AnalysisJan 09, 2023 P109094
B2320552Certificate of AnalysisJan 09, 2023 P109094
B2320553Certificate of AnalysisJan 09, 2023 P109094
B2320554Certificate of AnalysisJan 09, 2023 P109094
G2227445Certificate of AnalysisJun 09, 2022 P109094
G2227444Certificate of AnalysisJun 09, 2022 P109094
G2227443Certificate of AnalysisJun 09, 2022 P109094
G2227442Certificate of AnalysisJun 09, 2022 P109094
G2227441Certificate of AnalysisJun 09, 2022 P109094
C1810011Certificate of AnalysisJan 25, 2022 P109094
B2225730Certificate of AnalysisDec 08, 2021 P109094
B2225670Certificate of AnalysisDec 08, 2021 P109094
B2225666Certificate of AnalysisDec 08, 2021 P109094
B2225665Certificate of AnalysisDec 08, 2021 P109094
B2225664Certificate of AnalysisDec 08, 2021 P109094

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Chemical and Physical Properties

SolubilitySoluble in water (30 mg/ml), methanol (slightly), 1 M HCl (50 mg/ml), ethanol (<1 mg/ml at 25 °C), and DMSO (<1 mg/ml at 25 °C).
Specific Rotation[α]34 ° (C=2, H2O)
Melt Point(°C)273-276°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS AY7533000
Reaxy-Rn 2804068
Merck Index 7271

Related Documents

References

1. Christianson DW, Mangani S, Shoham G, Lipscomb WN.  (1989)  Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A..  J Biol Chem,  264  (22): (12849-53).  [PMID:2568989]
2. Seppo Parkkila,Daniela Vullo,Luca Puccetti,Anna-Kaisa Parkkila,Andrea Scozzafava,Claudiu T Supuran.  (2006-05-30)  Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines..  Bioorganic & medicinal chemistry letters,  16  ((15)): (3955-3959).  [PMID:16730978]
3. Daniela Vullo,Isao Nishimori,Alessio Innocenti,Andrea Scozzafava,Claudiu T Supuran.  (2006-12-19)  Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines..  Bioorganic & medicinal chemistry letters,  17  ((5)): (1336-1340).  [PMID:17174092]
4. Isao Nishimori,Saburo Onishi,Daniela Vullo,Alessio Innocenti,Andrea Scozzafava,Claudiu T Supuran.  (2007-05-15)  Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines..  Bioorganic & medicinal chemistry,  15  ((15)): (5351-5357).  [PMID:17499996]
5. Daniela Vullo,Alessio Innocenti,Isao Nishimori,Andrea Scozzafava,Kai Kaila,Claudiu T Supuran.  (2007-06-02)  Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines..  Bioorganic & medicinal chemistry letters,  17  ((15)): (4107-4112).  [PMID:17540561]
6. Silvia Pastorekova,Daniela Vullo,Isao Nishimori,Andrea Scozzafava,Jaromir Pastorek,Claudiu T Supuran.  (2008-02-26)  Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines..  Bioorganic & medicinal chemistry,  16  ((7)): (3530-3536).  [PMID:18294854]
7. Suneela S Dhaneshwar,Mukta Chail,Mahavir Patil,Salma Naqvi,Gaurav Vadnerkar.  (2008-05-13)  Colon-specific mutual amide prodrugs of 4-aminosalicylic acid for their mitigating effect on experimental colitis in rats..  European journal of medicinal chemistry,  44  ((1)): (131-142).  [PMID:18472188]
8. Daniela Vullo,Isao Nishimori,Andrea Scozzafava,Claudiu T Supuran.  (2008-07-17)  Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines..  Bioorganic & medicinal chemistry letters,  18  ((15)): (4303-4307).  [PMID:18627905]
9. Alessio Innocenti,Sabrina A Zimmerman,Andrea Scozzafava,James G Ferry,Claudiu T Supuran.  (2008-10-22)  Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines..  Bioorganic & medicinal chemistry letters,  18  ((23)): (6194-6198).  [PMID:18930395]
10. Semra Isik,Feray Kockar,Meltem Aydin,Oktay Arslan,Ozen Ozensoy Guler,Alessio Innocenti,Andrea Scozzafava,Claudiu T Supuran.  (2009-02-24)  Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids..  Bioorganic & medicinal chemistry letters,  19  ((6)): (1662-1665).  [PMID:19231177]
11. Suneela S Dhaneshwar,Neha Gairola,Mini Kandpal,Gaurav Vadnerkar,Lokesh Bhatt,Badal Rathi,S S Kadam.  (2009-05-16)  Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease..  European journal of medicinal chemistry,  44  ((10)): (3922-3929).  [PMID:19442419]
12. Alessio Innocenti,Mika Hilvo,Seppo Parkkila,Andrea Scozzafava,Claudiu T Supuran.  (2009-05-26)  Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines..  Bioorganic & medicinal chemistry letters,  19  ((13)): (3430-3433).  [PMID:19464888]
13. Alessio Innocenti,Rebecca A Hall,Andrea Scozzafava,Fritz A Mühlschlegel,Claudiu T Supuran.  (2010-01-12)  Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids..  Bioorganic & medicinal chemistry,  18  ((3)): (1034-1037).  [PMID:20061162]
14. Alessio Innocenti,Worraanong Leewattanapasuk,Gheorghe Manole,Andrea Scozzafava,Fritz A Mühlschlegel,Claudiu T Supuran.  (2010-02-05)  Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids..  Bioorganic & medicinal chemistry letters,  20  ((5)): (1701-1704).  [PMID:20129782]
15. Anthony Bertucci,Didier Zoccola,Sylvie Tambutté,Daniela Vullo,Claudiu T Supuran.  (2010-02-24)  Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines..  Bioorganic & medicinal chemistry,  18  ((6)): (2300-2303).  [PMID:20176489]
16. Takenori Satomura,Masaru Ishikura,Takashi Koyanagi,Haruhiko Sakuraba,Toshihisa Ohshima,Shin-ichiro Suye.  (2014-12-05)  Dye-linked D-amino acid dehydrogenase from the thermophilic bacterium Rhodothermus marinus JCM9785: characteristics and role in trans-4-hydroxy-L-proline catabolism..  Applied microbiology and biotechnology,  99  ((10)): (4265-4275).  [PMID:25472442]
17. Yasuo Yoshimi,Noriyuki Ishii.  (2015-02-16)  Improved gate effect enantioselectivity of phenylalanine-imprinted polymers in water by blending crosslinkers..  Analytica chimica acta,  862  (77-85).  [PMID:25682431]
18. Ruth Milkereit,Avinash Persaud,Liviu Vanoaica,Adriano Guetg,Francois Verrey,Daniela Rotin.  (2015-05-23)  LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation..  Nature communications,  (7250-7250).  [PMID:25998567]
19. Bin Cao,Zhenhua Li,Rong Peng,Jiandong Ding.  (2015-06-27)  Effects of cell-cell contact and oxygen tension on chondrogenic differentiation of stem cells..  Biomaterials,  64  (21-32).  [PMID:26113183]
20. Teresa Blazek,Waldemar Gorski.  (2020-06-23)  Oxidases, carbon nanotubes, and direct electron transfer: A cautionary tale..  Biosensors & bioelectronics,  163  (112260-112260).  [PMID:32568690]
21. Andrew T Schuster,Craig R Homer,Jacqueline R Kemp,Kourtney P Nickerson,Emily Deutschman,Yeojung Kim,Gail West,Tammy Sadler,Eleni Stylianou,Dawid Krokowski,Maria Hatzoglou,Carol de la Motte,Brian P Rubin,Claudio Fiocchi,Christine McDonald,Michelle S Longworth.  (2015-02-24)  Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters..  Gastroenterology,  148  ((7)): (1405-1416).  [PMID:25701737]
22. Jincheng Ni,Shunli Liu,Dong Wu,Zhaoxin Lao,Zhongyu Wang,Kun Huang,Shengyun Ji,Jiawen Li,Zhixiang Huang,Qihua Xiong,Yanlei Hu,Jiaru Chu,Cheng-Wei Qiu.  (2020-12-30)  Gigantic vortical differential scattering as a monochromatic probe for multiscale chiral structures..  Proceedings of the National Academy of Sciences of the United States of America,  118  ((2)):   [PMID:33372145]

Solution Calculators