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D(-)-Salicin - 99%, high purity , CAS No.138-52-3, Agonist of TAS2R16

  • Moligand™
  • ≥99%
Item Number
S104922
Grouped product items
SKUSizeAvailabilityPrice Qty
S104922-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$28.90
S104922-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$130.90
S104922-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$469.90
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NSAID. Salicyclic acid prodrug.

View related series
TAS2R16 Agonist

Basic Description

Synonymssalicin|138-52-3|Salicoside|D-(-)-Salicin|Salicine|Salicyl alcohol glucoside|D(-)-Salicin|(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-(hydroxymethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol|2-(Hydroxymethyl)phenyl beta-D-glucopyranoside|Saligenin beta-D-glucop
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsAn alcoholic β-glucoside which is metabolized to salicyclic acid. Cyclooxgenase inhibitor. Analgesic, neuroprotective, anti-inflammatory and antipyretic in vivo. Inhibits LPS-induced nitric oxide production in microglial cells. Orally active
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of TAS2R16
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

D-(-)-Salicin is an inhibitor of Cox. D-(-)-Salicin is also a substrate of β-glucosidase. Salicin is a non-phenolic glucosidic compound extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever. Salicin acts a metabolic precursor for salicylic acid It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.
An inhibitor of Cox

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCB11 Tchem Bile salt export pump 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TAS2R16 Tchem Taste receptor type 2 member 16 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
INCHI InChI=1S/C13H18O7/c14-5-7-3-1-2-4-8(7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1
InChi Key NGFMICBWJRZIBI-UJPOAAIJSA-N
Canonical SMILES C1=CC=C(C(=C1)CO)OC2C(C(C(C(O2)CO)O)O)O
Isomeric SMILES C1=CC=C(C(=C1)CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
WGK Germany 3
RTECS LZ5901700
Alternate CAS 138-52-3
PubChem CID 439503
NSC Number 758201
MeSH Entry Terms salicin;salicyl alcohol glucoside
Molecular Weight 286.28
Beilstein 89593
Reaxy-Rn 89593

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot NumberCertificate TypeDateItem
F2306525Certificate of AnalysisJan 11, 2023 S104922
F2306526Certificate of AnalysisJan 11, 2023 S104922
F2306528Certificate of AnalysisJan 11, 2023 S104922
F2207093Certificate of AnalysisMar 14, 2022 S104922
F2207109Certificate of AnalysisMar 14, 2022 S104922
D2121265Certificate of AnalysisMar 26, 2021 S104922
D2121266Certificate of AnalysisMar 26, 2021 S104922
D2121267Certificate of AnalysisMar 26, 2021 S104922

Chemical and Physical Properties

SolubilitySoluble in water (43 g/L) at 20 °C, alkalies, pyridine, glacial acetic acid, and Hot ethanol . Insoluble in ether, and chloroform.
SensitivityMoisture sensitive
Specific Rotation[α]-62 ° (C=3, H2O)
Melt Point(°C)199-202°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

WGK Germany 3
RTECS LZ5901700
Reaxy-Rn 89593
Merck Index 8324

Related Documents

 SDS

 Specification Sheet

References

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32. F M Zhu,B Du,H S Gao,C J Liu,J Li.  (2011-01-25)  Purification and characterization of an intracellular beta-glucosidase from the protoplast fusant of Aspergillus oryzae and Aspergillus niger..  Prikladnaia biokhimiia i mikrobiologiia,  46  ((6)): (678-684).  [PMID:21254729]
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