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D(-)-Salicin - 99%, high purity , CAS No.138-52-3, Agonist of TAS2R16

1 Citations
Item Number
S104922
Grouped product items
SKUSizeAvailabilityPrice Qty
S104922-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$28.90
S104922-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$130.90
S104922-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$469.90
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NSAID. Salicyclic acid prodrug.

View related series
TAS2R16 Agonist

Basic Description

SynonymsD-Salicin, United States Pharmacopeia (USP) Reference Standard | Spectrum4_001058 | 4649620TBZ | Benzyl alcohol, o-hydroxy-, o-glucoside | SDCCGMLS-0066698.P001 | WURCS=2.0/1,1,0/[a2122h-1b_1-5_1*O(C^ZC^ZC^ZC^ZC^ZC^E$3)/4CO]/1/ | AC-8042 | AKOS004907439 |
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsAn alcoholic β-glucoside which is metabolized to salicyclic acid. Cyclooxgenase inhibitor. Analgesic, neuroprotective, anti-inflammatory and antipyretic in vivo. Inhibits LPS-induced nitric oxide production in microglial cells. Orally active
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of TAS2R16
Note1g售完停产，不再备货Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

D-(-)-Salicin is an inhibitor of Cox. D-(-)-Salicin is also a substrate of β-glucosidase. Salicin is a non-phenolic glucosidic compound extracted from meadowsweet (Filipendula ulmaria L). It is majorly used as a substitute for quinine. Salicin can be used as a therapeutic for patients suffering from rheumatic fever. Salicin acts a metabolic precursor for salicylic acid It is a novel phytochemical that exhibits immunological cross functions in plants and humans. Salicin facilitates growth and reproduction in plants. In addition, It also protects plants against biotic and abiotic stress.
An inhibitor of Cox

Associated Targets(Human)

TAS2R16 Tchem Taste receptor type 2 member 16 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TAS2R16 Tchem Taste receptor type 2 member 16 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Microsporum canis (872 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterovirus C (520 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus niger (16508 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichophyton rubrum (3646 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 1 (11089 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Semliki Forest virus (705 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Measles morbillivirus (693 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Coxsackievirus (559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichophyton mentagrophytes (4846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chikungunya virus (1339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
INCHI InChI=1S/C13H18O7/c14-5-7-3-1-2-4-8(7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1
InChi Key NGFMICBWJRZIBI-UJPOAAIJSA-N
Canonical SMILES C1=CC=C(C(=C1)CO)OC2C(C(C(C(O2)CO)O)O)O
Isomeric SMILES C1=CC=C(C(=C1)CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O
WGK Germany 3
RTECS LZ5901700
Alternate CAS 138-52-3
PubChem CID 439503
NSC Number 758201
MeSH Entry Terms salicin;salicyl alcohol glucoside
Molecular Weight 286.28
Beilstein 89593
Reaxy-Rn 89593

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
F2306525Certificate of AnalysisJan 11, 2023 S104922
F2306526Certificate of AnalysisJan 11, 2023 S104922
F2306528Certificate of AnalysisJan 11, 2023 S104922
F2207093Certificate of AnalysisMar 14, 2022 S104922
F2207109Certificate of AnalysisMar 14, 2022 S104922
K2425027Certificate of AnalysisMar 14, 2022 S104922
D2121265Certificate of AnalysisMar 26, 2021 S104922
D2121266Certificate of AnalysisMar 26, 2021 S104922
D2121267Certificate of AnalysisMar 26, 2021 S104922

Chemical and Physical Properties

SolubilitySoluble in water (43 g/L) at 20 °C, alkalies, pyridine, glacial acetic acid, and Hot ethanol . Insoluble in ether, and chloroform.
SensitivityMoisture sensitive
Specific Rotation[α]-62 ° (C=3, H2O)
Melt Point(°C)199-202°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

WGK Germany 3
RTECS LZ5901700
Reaxy-Rn 89593
Merck Index 8324

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Zhenyue Wang, Faidah Arina Nur, Jingyi Ma, Jianguo Wang, Chuanwang Cao.  (2019)  Effects of poplar secondary metabolites on performance and detoxification enzyme activity of Lymantria dispar.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,  225  (108587).  [PMID:31401083] [10.1016/j.cbpc.2019.108587]

References

1. Sakurai T, Misaka T, Ueno Y, Ishiguro M, Matsuo S, Ishimaru Y, Asakura T, Abe K.  (2010)  The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides..  Biochem Biophys Res Commun,  402  (4): (595-601).  [PMID:20965151] [10.1021/op500134e]
2. Greene TA, Alarcon S, Thomas A, Berdougo E, Doranz BJ, Breslin PA, Rucker JB.  (2011)  Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin..  PLoS One,  6  (5): (e20123).  [PMID:21629661] [10.1021/op500134e]
3. Behrens M, Gunn HC, Ramos PC, Meyerhof W, Wooding SP.  (2013)  Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception..  Chem Senses,  38  (6): (475-84).  [PMID:23632915] [10.1021/op500134e]
4. M Sakurai,M Ohsako,M Nagano,C Nakamura,O Tsuzuki,M Ichikawa,Y Matsumoto.  (1996-08-01)  [Effect of human serum albumin on transport of drugs through human erythrocyte membranes]..  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,  116  ((8)): (630-638).  [PMID:8831264]
5. Xinfeng Zhang,Phuong Thien Thuong,Byung-Sun Min,Tran Minh Ngoc,Tran Manh Hung,Ik Soo Lee,MinKyun Na,Yeon-Hee Seong,Kyung-Sik Song,KiHwan Bae.  (2006-09-23)  Phenolic glycosides with antioxidant activity from the stem bark of Populus davidiana..  Journal of natural products,  69  ((9)): (1370-1373).  [PMID:16989539]
6. Xing Yun Chai,Yue Lin Song,Zheng Ren Xu,Hai Ming Shi,Chang Cai Bai,Dan Bi,Jing Wen,Fei Fei Li,Peng Fei Tu.  (2008-04-17)  Itosides J-N from Itoa orientalis and structure - anti-COX-2 activity relationship of phenolic glycosides..  Journal of natural products,  71  ((5)): (814-819).  [PMID:18412396]
7. Enkhmaa Dagvadorj,Kamel H Shaker,Donald Windsor,Bernd Schneider,Wilhelm Boland.  (2010-09-09)  Phenolic glucosides from Hasseltia floribunda..  Phytochemistry,  71  ((16)): (1900-1907).  [PMID:20822782]
8. Ilkay Erdogan-Orhan,Mehmet Levent Altun,Betül Sever-Yilmaz,Gülçin Saltan.  (2010-12-29)  Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents..  Journal of medicinal food,  14  ((4)): (434-440).  [PMID:21186982]
9. J Vlachojannis,F Magora,S Chrubasik.  (2011-01-13)  Willow species and aspirin: different mechanism of actions..  Phytotherapy research : PTR,  25  ((7)): (1102-1104).  [PMID:21226125]
10. Susanne Knuth,Helmut Schübel,Martin Hellemann,Guido Jürgenliemk.  (2011-02-10)  Catechol, a bioactive degradation product of salicortin, reduces TNF-α induced ICAM-1 expression in human endothelial cells..  Planta medica,  77  ((10)): (1024-1026).  [PMID:21305449]
11. Roy Kirsch,Heiko Vogel,Alexander Muck,Andreas Vilcinskas,Jacques M Pasteels,Wilhelm Boland.  (2011-03-25)  To be or not to be convergent in salicin-based defence in chrysomeline leaf beetle larvae: evidence from Phratora vitellinae salicyl alcohol oxidase..  Proceedings. Biological sciences,  278  ((1722)): (3225-3232).  [PMID:21429930]
12. Peter Hewitson,Svetlana Ignatova,Ian Sutherland.  (2011-05-17)  Intermittent counter-current extraction--effect of the key operating parameters on selectivity and throughput..  Journal of chromatography. A,  1218  ((36)): (6072-6078).  [PMID:21571282]
13. Zoe Diana Draelos.  (2011-08-10)  The art and science of new advances in cosmeceuticals..  Clinics in plastic surgery,  38  ((3)): (397-407).  [PMID:21824538]
14. .  (2011-09-16)  New bitter blocker discovered, study finds..  Journal of the American Dental Association (1939),  142  ((8)): (901-901).  [PMID:21919220]
15. G Ulrich-Merzenich,A Koptina,O Kelber,A Freischmidt,J Heilmann,J Müller,F Sadeghlar,H Zeitler,H Wagner.  (2011-11-29)  Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine..  Phytomedicine : international journal of phytotherapy and phytopharmacology,  19  ((3-4)): (322-329).  [PMID:22119042]
16. Brian S Luisi,Ales Medek,Zhouyuan Liu,Praveen Mudunuri,Brian Moulton.  (2012-01-04)  Milling-induced disorder of pharmaceuticals: one-phase or two-phase system?.  Journal of pharmaceutical sciences,  101  ((4)): (1475-1485).  [PMID:22213593]
17. Gabriela C Schmitt,Marcelo D Arbo,Andréia L Lorensi,Erica S Maciel,Carolina L Krahn,Kristiane C Mariotti,Eliane Dallegrave,Mirna B Leal,Renata P Limberger.  (2012-03-13)  Toxicological effects of a mixture used in weight loss products: p-synephrine associated with ephedrine, salicin, and caffeine..  International journal of toxicology,  31  ((2)): (184-191).  [PMID:22408069]
18. Derek Doyle.  (2012-03-22)  Thomas John MacLagan (1838-1903)..  Journal of the Royal Society of Medicine,  105  ((3)): (131-136).  [PMID:22434813]
19. Tetsuya Iizuka,Toshiki Tamura,Hideki Sezutsu,Keisuke Mase,Eiji Okada,Kiyoshi Asaoka.  (2012-06-01)  Genetic analysis of the electrophysiological response to salicin, a bitter substance, in a polyphagous strain of the silkworm Bombyx mori..  PloS one,  7  ((5)): (e37549-e37549).  [PMID:22649537]
20. G Ulrich-Merzenich,O Kelber,A Koptina,A Freischmidt,J Heilmann,J Müller,H Zeitler,M F Seidel,M Ludwig,E U Heinrich,H Winterhoff.  (2012-06-30)  Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine..  Phytomedicine : international journal of phytotherapy and phytopharmacology,  19  ((10)): (930-939).  [PMID:22743246]
21. Jiang Xu,Jie Cao,Naoko Iguchi,Dieter Riethmacher,Liquan Huang.  (2012-09-18)  Functional characterization of bitter-taste receptors expressed in mammalian testis..  Molecular human reproduction,  19  ((1)): (17-28).  [PMID:22983952]
22. Sara Agnolet,Stefanie Wiese,Robert Verpoorte,Dan Staerk.  (2012-10-02)  Comprehensive analysis of commercial willow bark extracts by new technology platform: combined use of metabolomics, high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy and high-resolution radical scavenging assay..  Journal of chromatography. A,  1262  (130-137).  [PMID:23021634]
23. Xiao-Hua Wei,Sheng-Jie Yang,Na Liang,De-Yu Hu,Lin-Hong Jin,Wei Xue,Song Yang.  (2013-01-24)  Chemical constituents of Caesalpinia decapetala (Roth) Alston..  Molecules (Basel, Switzerland),  18  ((1)): (1325-1336).  [PMID:23340256]
24. Jasbir D Upadhyaya,Nisha Singh,Anurag S Sikarwar,Raja Chakraborty,Sai P Pydi,Rajinder P Bhullar,Shyamala Dakshinamurti,Prashen Chelikani.  (2014-10-24)  Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction..  PloS one,  9  ((10)): (e110373-e110373).  [PMID:25340739]
25. Véronique Gilard,Stéphane Balayssac,Aurélie Tinaugus,Nathalie Martins,Robert Martino,Myriam Malet-Martino.  (2014-12-03)  Detection, identification and quantification by 1H NMR of adulterants in 150 herbal dietary supplements marketed for improving sexual performance..  Journal of pharmaceutical and biomedical analysis,  102  (476-493).  [PMID:25459948]
26. Charles J Mason,Kennedy F Rubert-Nason,Richard L Lindroth,Kenneth F Raffa.  (2014-12-06)  Aspen defense chemicals influence midgut bacterial community composition of gypsy moth..  Journal of chemical ecology,  41  ((1)): (75-84).  [PMID:25475786]
27. Min Jung Kim,Hee Jin Son,Yiseul Kim,Takumi Misaka,Mee-Ra Rhyu.  (2014-12-10)  Umami-bitter interactions: the suppression of bitterness by umami peptides via human bitter taste receptor..  Biochemical and biophysical research communications,  456  ((2)): (586-590).  [PMID:25490385]
28. Stefan Pentzold,Frédéric Marion-Poll,Veit Grabe,Antje Burse.  (2019-04-20)  Autofluorescence-Based Identification and Functional Validation of Antennal Gustatory Sensilla in a Specialist Leaf Beetle..  Frontiers in physiology,  10  (343-343).  [PMID:31001138]
29. J G Mahdi,A J Mahdi,A J Mahdi,I D Bowen.  (2006-03-18)  The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential..  Cell proliferation,  39  ((2)): (147-155).  [PMID:16542349]
30. Yuko Ogawa,Hisae Oku,Emiko Iwaoka,Munekazu Iinuma,Kyoko Ishiguro.  (2006-08-29)  Allergy-preventive phenolic glycosides from Populus sieboldii..  Journal of natural products,  69  ((8)): (1215-1217).  [PMID:16933880]
31. Remona Gopaul,Helen E Knaggs,Janet F Lephart,Kara C Holley,Erica M Gibson.  (2010-10-05)  An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging..  Journal of cosmetic dermatology,  9  ((3)): (196-201).  [PMID:20883292]
32. F M Zhu,B Du,H S Gao,C J Liu,J Li.  (2011-01-25)  Purification and characterization of an intracellular beta-glucosidase from the protoplast fusant of Aspergillus oryzae and Aspergillus niger..  Prikladnaia biokhimiia i mikrobiologiia,  46  ((6)): (678-684).  [PMID:21254729]
33. Roy Kirsch,Heiko Vogel,Alexander Muck,Kathrin Reichwald,Jacques M Pasteels,Wilhelm Boland.  (2011-03-09)  Host plant shifts affect a major defense enzyme in Chrysomela lapponica..  Proceedings of the National Academy of Sciences of the United States of America,  108  ((12)): (4897-4901).  [PMID:21383196]
34. Hiroo Imai,Nami Suzuki,Yoshiro Ishimaru,Takanobu Sakurai,Lijie Yin,Wenshi Pan,Keiko Abe,Takumi Misaka,Hirohisa Hirai.  (2012-03-09)  Functional diversity of bitter taste receptor TAS2R16 in primates..  Biology letters,  8  ((4)): (652-656).  [PMID:22399783]
35. Mahla Mirali,Stephen J Ambrose,Stephen A Wood,Albert Vandenberg,Randy W Purves.  (2014-09-01)  Development of a fast extraction method and optimization of liquid chromatography-mass spectrometry for the analysis of phenolic compounds in lentil seed coats..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  969  (149-161).  [PMID:25173496]
36. Ken Keefover-Ring,Maria Ahnlund,Ilka Nacif Abreu,Stefan Jansson,Thomas Moritz,Benedicte Riber Albrectsen.  (2014-10-10)  No evidence of geographical structure of salicinoid chemotypes within Populus tremula..  PloS one,  9  ((10)): (e107189-e107189).  [PMID:25299342]
37. Hanna Oltean,Chris Robbins,Maurits W van Tulder,Brian M Berman,Claire Bombardier,Joel J Gagnier.  (2014-12-24)  Herbal medicine for low-back pain..  The Cochrane database of systematic reviews,  12  ((12)): (CD004504-CD004504).  [PMID:25536022]
38. Yang Li,Qianchao Wu,Yanhong Deng,Hongming Lv,Jiaming Qiu,Gefu Chi,Haihua Feng.  (2015-04-25)  D(-)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models..  International immunopharmacology,  26  ((2)): (286-294).  [PMID:25907238]
39. Zhenyue Wang, Faidah Arina Nur, Jingyi Ma, Jianguo Wang, Chuanwang Cao.  (2019)  Effects of poplar secondary metabolites on performance and detoxification enzyme activity of Lymantria dispar.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,  225  (108587).  [PMID:31401083] [10.1016/j.cbpc.2019.108587]

Solution Calculators

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