D-Valine - 98%, high purity , CAS No.640-68-6

  • ≥98%
Item Number
V101067
Grouped product items
SKUSizeAvailabilityPrice Qty
V101067-1g
1g
In stock
$27.90
V101067-5g
5g
In stock
$123.90
V101067-10g
10g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$223.90
V101067-25g
25g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$502.90
V101067-100g
100g
In stock
$1,807.90
V101067-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$8,133.90

Basic Description

SynonymsEINECS 211-368-9 | C06417 | DVA | (R)-alpha-Aminoisovaleric acid | NSC-20654 | AKOS006240045 | D-(-)-VALINE | H-D-Val-OH | NCGC00159470-02 | R-Valine | Thioethyl alcohol | AM82362 | (R)-2-Amino-3-methylbutyric acid | D-Val | A847288 | VALNEMULIN HYDROCHLO
Specifications & Purity≥98%
Shipped InNormal
Product Description

D-Valine is a selective inhibitor of cell proliferation. It inhibit cells that lack the enzyme D-amino acid oxidase. D-Valine has been shown to inhibit fibroblast growth while allowing selective growth of epithelial cells. L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.
An isomer of the essential amino acid L-Valine

Associated Targets(Human)

RUNX1 Tbio Runt-related transcription factor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC7A5 Tchem Large neutral amino acids transporter small subunit 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LMNA Tbio Prelamin-A/C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488184661
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184661
IUPAC Name (2R)-2-amino-3-methylbutanoic acid
INCHI InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
InChi Key KZSNJWFQEVHDMF-SCSAIBSYSA-N
Canonical SMILES CC(C)C(C(=O)O)N
Isomeric SMILES CC(C)[C@H](C(=O)O)N
WGK Germany 3
RTECS YV9360000
PubChem CID 71563
Molecular Weight 117.15
Beilstein 1721135
Reaxy-Rn 1721135

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot NumberCertificate TypeDateItem
E2308605Certificate of AnalysisNov 09, 2022 V101067
E2415060Certificate of AnalysisNov 09, 2022 V101067
L2214542Certificate of AnalysisNov 09, 2022 V101067
L2214543Certificate of AnalysisNov 09, 2022 V101067
L2214544Certificate of AnalysisNov 09, 2022 V101067
L2214545Certificate of AnalysisNov 09, 2022 V101067
L2214546Certificate of AnalysisNov 09, 2022 V101067
L2214547Certificate of AnalysisNov 09, 2022 V101067
J2219115Certificate of AnalysisOct 21, 2022 V101067
L1812106Certificate of AnalysisSep 21, 2022 V101067
D1813135Certificate of AnalysisFeb 18, 2022 V101067
B2317052Certificate of AnalysisMay 08, 2021 V101067
B2317071Certificate of AnalysisMay 08, 2021 V101067
K2209070Certificate of AnalysisMay 08, 2021 V101067
K2209071Certificate of AnalysisMay 08, 2021 V101067

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Chemical and Physical Properties

SolubilitySoluble in water (56 mg/ml at 20° C), Aqueous Acid, and 3N HCI. Insoluble in ethanol, and ether.
Specific Rotation[α]-27 ° (C=8, 6mol/L HCl)
Melt Point(°C)302-303°C

Safety and Hazards(GHS)

WGK Germany 3
RTECS YV9360000
Reaxy-Rn 1721135

Related Documents

Citations of This Product

1. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai.  (2023)  Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point.  Advanced Science,    (2308362).  [PMID:38072636] [10.1002/advs.202308362]
2. Li Gao, Piao Xu, Jiaoyan Ren.  (2023)  A sensitive and economical method for simultaneous determination of D/L- amino acids profile in foods by HPLC-UV: Application in fermented and unfermented foods discrimination.  FOOD CHEMISTRY,  410  (135382).  [PMID:36628920] [10.1016/j.foodchem.2022.135382]
3. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,  243  (123363).  [PMID:35272154] [10.1016/j.talanta.2022.123363]
4. Jun Zhang, Tingyang Xing, Min Zhang, Yunlong Zhou.  (2022)  Facile preparation of Cu2-xS supernanoparticles with an unambiguous SERS enhancement mechanism.  CHEMICAL ENGINEERING JOURNAL,  434  (134457).  [PMID:] [10.1016/j.cej.2021.134457]
5. Deng Jun, Wu Sai, Yao Mengyun, Gao Changyou.  (2016)  Surface-anchored poly(acryloyl-L(D)-valine) with enhanced chirality-selective effect on cellular uptake of gold nanoparticles.  Scientific Reports,  (1): (1-12).  [PMID:27531648] [10.1038/srep31595]

References

1. Gerald I Richard,Hadi M Marwani,Shan Jiang,Sayo O Fakayode,Mark Lowry,Robert M Strongin,Isiah M Warner.  (2008-05-24)  Chiral recognition of amino acids by use of a fluorescent resorcinarene..  Applied spectroscopy,  62  ((5)): (476-480).  [PMID:18498687]
2. Iris Thondorf,Valerie Voigt,Sarah Schäfer,Sabine Gebauer,Katja Zebisch,Linda Laug,Matthias Brandsch.  (2011-10-01)  Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1)..  Bioorganic & medicinal chemistry,  19  ((21)): (6409-6418).  [PMID:21955456]
3. Brian R Tuinema,Sarah A Reid-Yu,Brian K Coombes.  (2014-11-27)  Salmonella evades D-amino acid oxidase to promote infection in neutrophils..  mBio,  ((6)): (e01886-e01886).  [PMID:25425233]
4. Kimberly A Smith,Guillaume Voiriot,Haiyang Tang,Dustin R Fraidenburg,Shanshan Song,Hisao Yamamura,Aya Yamamura,Qiang Guo,Jun Wan,Nicole M Pohl,Mohammad Tauseef,Rolf Bodmer,Karen Ocorr,Patricia A Thistlethwaite,Gabriel G Haddad,Frank L Powell,Ayako Makino,Dolly Mehta,Jason X-J Yuan.  (2015-01-09)  Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension..  American journal of respiratory cell and molecular biology,  53  ((3)): (355-367).  [PMID:25569851]
5. Dean P J Kavanagh,Shankar Suresh,Philip N Newsome,Jon Frampton,Neena Kalia.  (2015-07-01)  Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut..  Stem cells (Dayton, Ohio),  33  ((9)): (2785-2797).  [PMID:26124062]
6. Shanshan Song,Aya Yamamura,Hisao Yamamura,Ramon J Ayon,Kimberly A Smith,Haiyang Tang,Ayako Makino,Jason X-J Yuan.  (2014-06-13)  Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension..  American journal of physiology. Cell physiology,  307  ((4)): (C373-C383).  [PMID:24920677]
7. Stefan M Gysler,Melissa J Mulla,Meredith Stuhlman,Anna K Sfakianaki,Michael J Paidas,Nancy L Stanwood,Aileen Gariepy,Jan J Brosens,Lawrence W Chamley,Vikki M Abrahams.  (2014-07-30)  Vitamin D reverses aPL-induced inflammation and LMWH-induced sFlt-1 release by human trophoblast..  American journal of reproductive immunology (New York, N.Y. : 1989),  73  ((3)): (242-250).  [PMID:25070806]
8. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai.  (2023)  Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point.  Advanced Science,    (2308362).  [PMID:38072636] [10.1002/advs.202308362]
9. Li Gao, Piao Xu, Jiaoyan Ren.  (2023)  A sensitive and economical method for simultaneous determination of D/L- amino acids profile in foods by HPLC-UV: Application in fermented and unfermented foods discrimination.  FOOD CHEMISTRY,  410  (135382).  [PMID:36628920] [10.1016/j.foodchem.2022.135382]
10. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,  243  (123363).  [PMID:35272154] [10.1016/j.talanta.2022.123363]
11. Jun Zhang, Tingyang Xing, Min Zhang, Yunlong Zhou.  (2022)  Facile preparation of Cu2-xS supernanoparticles with an unambiguous SERS enhancement mechanism.  CHEMICAL ENGINEERING JOURNAL,  434  (134457).  [PMID:] [10.1016/j.cej.2021.134457]
12. Deng Jun, Wu Sai, Yao Mengyun, Gao Changyou.  (2016)  Surface-anchored poly(acryloyl-L(D)-valine) with enhanced chirality-selective effect on cellular uptake of gold nanoparticles.  Scientific Reports,  (1): (1-12).  [PMID:27531648] [10.1038/srep31595]

Solution Calculators