D4476 - ≥98%, high purity , CAS No.301836-43-1, Inhibitor of casein kinase 1 alpha 1;Inhibitor of casein kinase 1 delta

Item Number

D125927

• Synonyms: D4476, >=98% (HPLC), solid | HMS3266B22 | 2-[bis(2-chloroethyl)amino]-1,3,2 | NSC-6253 | HMS3413F18 | SMR004701747 | 4-[4-(2,3-dihydro-1, 4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]-benzamide | BD162789 | HMS3229C20 | NCGC00242498-01 | NCGC002424
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: D4476 is a cell-permeable triaryl substituted imidazolo compound that acts as a selective inhibitor of casein kinase 1 (CK1) and TGFβ RI (TGF-βtype-I receptor, ALK5). Weak inhibitor of Polycystin-1 (PKD1), p38? (p38α MAPK) and only weakly affects the acti
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of casein kinase 1 alpha 1;Inhibitor of casein kinase 1 delta
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

D4476, a cell-permeant inhibitor of CK1δ (IC90 <10 uM), originally identified as inhibitors of activin receptor-like kinase ALK5.
A cell-permeable triaryl substituted imidazolo compound that acts as a selective inhibitor of casein kinase 1 (CK1).